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Preparation of PLGA-collagen hybrid scaffolds with controlled pore structures for cartilage tissue engineering

Progress in Natural Science:Materials International 2020年第5期30卷 642-650页

作者： Nur Rofiqoh Eviana Putri Xiuhui Wang Ying Chen Xiaomeng Li Naoki Kawazoe Guoping Chen Research Center for Functional Materials National Institute for Materials Science Department of Materials Science and Engineering Graduate School of Pure and Applied Sciences University of Tsukuba Departement of Chemical Engineering Faculty of Engineering Universitas Gadjah Mada

scaffolds used for cartilage tissue engineering should have high mechanical strength and well-controlled pore structure to provide suitable microenvironments for functional tissue regeneration. In this study, hybrid scaffolds which had open and interconnected pore structure and high mechanical property were prepared by hybridization of PLGA mesh and collagen using ice particulates as porogen templates. Embossing ice particulates template was used to form open pore structures on the scaffold surfaces. Free ice particulates were used to generate interconnected bulk pores in the scaffolds. hybridization with PLGA mesh provided the scaffolds with high mechanical property. Bovine articular chondrocytes were cultured in the hybrid scaffolds. The unique pore structures facilitated the homogeneous distribution of chondrocytes and cartilaginous matrices throughout the scaffolds. Subcutaneous implantation demonstrated cartilage-like tissue regeneration. The hybrid scaffolds should have a high potential for cartilage tissue engineering.

关键词： hybrid scaffolds Porous scaffolds PLGA Collagen Cartilage tissue engineering

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Immunomodulatory hybrid micro-nanofiber scaffolds enhance vascular regeneration

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Bioactive Materials 2023年第3期21卷 464-482页

作者： Yuanjing Hu Deling Kong Xianhao Dong Kai Wang Meifeng Zhu College of Life Sciences Key Laboratory of Bioactive Materials(Ministry of Education)State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin300071China Tianjin Central Hospital of Obstetrics and Gynecology/Tianjin Key Laboratory of Human Development and Reproductive Regulation Tianjin Central Hospital of Gynecology ObstetricsTianjin300199China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

The inertness of synthetic polymer materials and the insufficient mechanical strength of reprocessed decellu-larized extracellular matrix(dECM)limited their promotive efforts on tissue ***,we prepared a hybrid scaffold composed of PCL microfibers and human placental extracellular matrix(pECM)nanofibers by co-electrospinning,which was grafted with heparin and further absorbed with *** hybrid scaffold with improved hemocompatibility firstly switched macrophages to anti-inflammatory phenotype(increased by 18.1%)and then promoted migration,NO production,tube formation of endothelial cells(ECs),and migration and maturation of vascular smooth muscle cells(VSMCs),and ECM deposition in vitro and in *** coverage rate increased by 8.6%and the thickness of the smooth muscle layer was 1.8 times more than PCL grafts at 12 *** study realized the complementary advantages of synthetic polymer materials and dECM materials,and opened intriguing perspectives for the design and construction of small-diameter vascular grafts(SDVGs)and immune-regulated materials for other tissue regeneration.

关键词： hybrid scaffolds PCL microfiber Placental ECM nanofiber Immunoregulation Vascular regeneration

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