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Controlled Synthesis of Metal-nanoparticles Decorated Block Copolymer hybrid Particles via Emulsion Confined Self-assembly and Their Catalytic Applications

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Chinese Journal of Chemistry 2024年第8期42卷 835-840页

作者： Xiaohua Chang Qunli Yu Dan Ji Yutian Zhu College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhouZhejiang311121 China

Comprehensive Summary Metal nanoparticles(NPs)decorated block copolymer(BCP)hybrid nanoparticles have attracted enormous attention for their actual value in catalysis,medical therapy,and *** confined assembly of BCPs within evaporative emulsion droplet is verified as an effective method to provide polymeric scaffolds to load metal ***,to date,it remains challenging to generate different types of metal NPs decorated BCP hybrid ***,we employed the emulsion confined self-assembly of poly(styrene-b-2-vinylpyridine)(PS-b-P2VP)and the followed seed-mediated growth of Au and palladium(Pd)NPs onto well-defined BCP particles to design a series of Au/Pd decorated BCP hybrid nanoparticles,which exhibited excellent catalytic activity for the reduction of 4-nitrophenol to 4-aminophenol with the reductant of *** work may inspire more researchers to investigate the selective decoration of different metal NPs onto the polymeric scaffolds,broadening the potential applications of the inorganic/organic hybrid nanoparticles.

关键词： Block copolymers Emulsion confined self-assembly hybrid nanoparticles Catalytic activity Recyclability

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Evaluation of Cisplatin-Loaded Polymeric Micelles and hybrid nanoparticles Containing Poly(Ethylene Oxide)-Block-Poly(Methacrylic Acid) on Tumor Delivery

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Pharmacology & Pharmacy 2016年第1期7卷 1-8页

作者： Andang Miatmoko Kumi Kawano Etsuo Yonemochi Yoshiyuki Hattori Department of Drug Delivery Research Hoshi University Shinagawa Japan Department of Physical Chemistry Hoshi University Shinagawa Japan

Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid nanoparticles (HNPs) with poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-b-PMAA) for loading cisplatin, and evaluated cisplatin release, cytotoxicity, and biodistribution in mice. PM composed of PEO-b-PMAA and HNPs composed of egg phosphatidylcholine (EPC)/PEO-b-PMAA at molar ratios of 50/2.8 (HNP-P5) and 50/50 (HNP-P50), respectively, were prepared by a nanoprecipitation method. The sizes of PM, HNP-P5, and HNP-P50 after inclusion of cisplatin were approximately 200, 100, and 55 nm, respectively, and their entrapment efficiencies were approximately 44% - 66%. In the drug-release study, HNP-P5 and HNP-P50 showed reduced release of cisplatin compared with PM. Regarding the cytotoxic assay, HNP-P5 exhibited lower cytotoxicity for mouse Lewis lung carcinoma (LLC) and mouse colon carcinoma Colon 26 cells than PM and HNP-P50. In terms of biodistribution, PM could significantly improve blood circulation and tumor accumulation after intravenous injection into Colon 26 tumor-bearing mice compared with free cisplatin, but HNP-P5 and HNP-P50 did not. EPC in HNPs might be destabilized in the circulation, although it could reduce release of cisplatin in in vitro experiments. This study suggested that polymeric micelles composed of PEO-b-PMAA are a better carrier for cisplatin than hybrid nanoparticles composed of PEO-b-PMAA and EPC.

关键词： Polymeric Micelles hybrid nanoparticles Cisplatin PEO-b-PMAA

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A Facile Approach to Fabricate Water-soluble Au-Fe3O4 Nanoparticle for Liver Cancer Cells Imaging

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Chinese Journal of Chemistry 2012年第7期30卷 1387-1392页

作者：梁重时吴献荣谢叶归刘顺英 Shanghai Engineering Research Center for Molecular Theraputics and New Drug Development East China Normal UniversityShanghai 200062China

Au-Fe3O4 nanoparticles were widely used as nanoplatforms for biologic applications through readily further functionalization. Dopamine （DA）-coated superparamagnetic iron oxide （SPIO） nanoparticles （DA@Fe3O4） have been successfully synthesized using a one-step process by modified coprecipitation method. Then 2--3 nm gold nanoparticles were easily conjugated to DA@Fe3O4 nanoparticles by the electrostatic force between gold nanoparti- cles and amino groups of dopamine to afford water-soluble Au-Fe3O4 hybrid nanoparticles. A detailed investigation by dynamic light scatting （DLS）, transmission electron microscopy （TEM）, fourier transform infrared （FT-IR） and X-ray diffraction （XRD） were performed in order to characterize the physicochemical properties of the hybrid nanoparticles. The hybrid nanoparticles were easily functionalized with a targeted small peptide A54 （AGKGTPSLETTP） and fluorescence probe fluorescein isothiocyanate （FITC） for liver cancer cell BEL-7402 imaging. This simple approach to prepare hybrid nanoparticles provides a facile nanoplatform for muti-functional derivations and may be extended to the immobilization of other metals or bimolecular on SPIO surface.

关键词： dopamine gold superparamagnetic iron oxide hybrid nanoparticles cell imaging

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Magnetohydrodynamic flow and heat transfer of a hybrid nanofluid over a rotating disk by considering Arrhenius energy

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Communications in Theoretical Physics 2021年第4期73卷 9-20页

作者： M Gnaneswara Reddy Naveen Kumar R B C Prasannakumara N G Rudraswamy K Ganesh Kumar Department of Mathematics Acharya Nagarjuna University CampusOngole-523001India Department of Studies and Research in Mathematics Davangere UniversityShivagangothriDavangere-577007KarnatakaIndia Department of Mathematics P.C.Jabin Science CollageHubballi-580031India

This research work explores the effect of hybrid nanoparticles on the flow over a rotating disk by using an activation energy ***,we considered molybdenum disulfide and ferro sulfate as nanoparticles suspended in base fluid *** magnetic field is pragmatic normal to the hybrid nanofluid flow *** derived nonlinear ordinary differential equations are non-dimensionalized and worked out numerically with the help of Maple software by the RKF-45 *** scientific results for a non-dimensionalized equation are presented for both nanoparticle and hybrid nanoparticle *** of various predominant restrictions on flow and thermal fields are *** estimation for friction factor,local Nusselt number and Sherwood number are also *** reveal that the reduction of the heat transfer rate is greater in hybrid nanoparticles when compared to nanoparticles for increasing values of Eckert Number and the thermal field enhances for the enhanced values of volume fraction.

关键词： porous medium MHD hybrid nanoparticles activation energy

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Functional Inorganic-Organic hybrid Nanomaterials for Theranostic Applications

Functional Inorganic-Organic Hybrid Nanomaterials for Theran...

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第十一届全国化学生物学学术会议

作者： Yuna Qian Zong-Wan Mao 沈建良 Wenzhou Institute University of Chinese Academy of Sciences MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yatsen University 中科院温州生物材料与工程研究所

Patients with cancer have limited treatment options,since some the diseases do not respond to endocrine or targeted *** 15% of breast cancers are classified as triple negative,which is a highly aggressive form of breast cancer that lacks expression of the estrogen receptor（ER）,progesterone receptor（PR）,and Her2/***,therapeutic options are limited for the TNBC patients as hormonal and targeted therapies cannot be ***,there is an urgent need to develop new therapeutic agents against ***,we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA,combination,theranostic therapeutics ***-organic hybrid platforms as the vectors for drug delivery are promising to give credit to the interdisciplinary cooperation between inorganic,organic,biology and medicine.

关键词： Cancer RNA interference Theranostic applications hybrid nanoparticles

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Functional Inorganic-Organic hybrid Nanomaterials for Theranostic Applications

Functional Inorganic-Organic Hybrid Nanomaterials for Theran...

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中国化学会第十四届全国生物无机化学学术会议

作者： Yuna Qian Zong-Wan Mao 沈建良 Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Science MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-sen University State Key Laboratory of Ophthalmology Optometry and Vision Science Wenzhou Medical University

Patients with cancer have limited treatment options, since some the diseases do not respond to endocrine or targeted therapies. Approximately 15% of breast cancers are classified as triple negative, which is a highly aggressive form of breast cancer that lacks expression of the estrogen receptor（ER）, progesterone receptor（PR）, and Her2/neu. Therefore, therapeutic options are limited for the TNBC patients as hormonal and targeted therapies cannot be exploited. Accordingly, there is an urgent need to develop new therapeutic agents against TNBC. Here, we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA, combination, theranostic therapeutics advancements. Inorganic-organic hybrid platforms as the vectors for drug delivery are promising to give credit to the interdisciplinary cooperation between inorganic, organic, biology and medicine.

关键词： Cancer RNA interference Theranostic applications hybrid nanoparticles

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