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Construction of Electrospun Organic/Inorganic hybrid nanofibers for Drug Delivery and Tissue Engineering Applications

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Advanced Fiber Materials 2019年第1期1卷 32-45页

作者： Wei Huang Yunchao Xiao Xiangyang Shi State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials International Joint Laboratory for Advanced Fiber and Low-dimension MaterialsCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620People’s Republic of China CQM-Centro de Química da Madeira Universidade da MadeiraCampus da Penteada9000-390 FunchalPortugal

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area,good biocompatibility,easy fabrication and surface *** particular,organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs,which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering *** review summarizes the recent progresses in the preparation,performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy,and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering *** doped with various types of inorganic nanoparticles(e.g.,halloysite,laponite®,nano-hydroxyapatite,attapulgite,carbon nanotubes,and graphene,etc.)are introduced and summarized in *** perspectives are also briefly discussed.

关键词： Electrospun nanofibers hybrid nanofibers Drug delivery Tissue engineering

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Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration

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Neural Regeneration Research 2023年第1期18卷 200-206页

作者： Wei Zhang Xing-Xing Fang Qi-Cheng Li Wei Pi Na Han Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina National Center for Trauma Medicine BeijingChina Central Laboratory Peking University People’s HospitalBeijingChina

We previously combined reduced graphene oxide(rGO)with gelatin-methacryloyl(GelMA)and polycaprolactone(PCL)to create an rGO-GelMA-PCL nerve conduit and found that the conductivity and biocompatibility were ***,the rGO-GelMA-PCL nerve conduits differed greatly from autologous nerve transplants in their ability to promote the regeneration of injured peripheral nerves and axonal *** vesicles derived from bone marrow mesenchymal stem cells(BMSCs)can be loaded into rGO-GelMA-PCL nerve conduits for repair of rat sciatic nerve injury because they can promote angiogenesis at the injured *** this study,12 weeks after surgery,sciatic nerve function was measured by electrophysiology and sciatic nerve function index,and myelin sheath and axon regeneration were observed by electron microscopy,immunohistochemistry,and *** regeneration of microvessel was observed by *** results showed that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles were superior to rGO-GelMA-PCL conduits alone in their ability to increase the number of newly formed vessels and axonal sprouts at the injury site as well as the recovery of neurological *** findings indicate that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles can promote peripheral nerve regeneration and neurological function recovery,and provide a new direction for the curation of peripheral nerve defect in the clinic.

关键词： angiogenesis axon bone mesenchymal stem cell extracellular vesicles hybrid nanofibers myelin sheath nerve conduit neurological function peripheral nerve injury reduced graphene oxide

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