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Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

引用

Bioactive Materials 2021年第2期6卷 433-446页

作者： Ye Liang Yonghua Wang Liping Wang Zhijuan Liang Dan Li Xiaoyu Xu Yuanbin Chen Xuecheng Yang Hongbo Zhang Haitao Niu Key Laboratory of Urology and Andrology Medical Research CentreAffiliated Hospital of Qingdao UniversityQingdao266003China Department of Urology Affiliated Hospital of Qingdao UniversityQingdao266003China Pharmaceutical Sciences Laboratory and Turku Bioscience Centre Åbo Akademi UniversityTurku20520Finland

Bladder cancer is one of the concerning malignancies worldwide,which is lacking effective targeted *** therapy is a potential approach for bladder cancer ***,a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in *** this study,we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs(siRNA)with high interfere to Bcl2 oncogene were designed and *** hyaluronic acid dialdehyde(HAD)was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles(CS-HAD NPs)to achieve CD44 targeted siRNA *** in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs(siRNA@CS-HAD NPs)were approximately 100 nm in size,with improved stability,high siRNA encapsulation efficiency and low ***-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder ***,a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment,which could be more conducive to clinical application due to its simple preparation and high biological safety.

关键词： siRNA delivery Chitosan hyaluronic acid dialdehyde CD44 targeting Bladder cancer

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