检索结果-南通市图书馆

hutchinson-gilford综合征1例报告

引用

山东医药 1992年第8期 63-63页

作者：魏美文张孝中山东医科大学附属医院

患儿女,9岁,因自幼消瘦、脱发1年来我院就诊。患儿生后不久即食欲不振,消瘦,体重增长缓慢,于1年前开始大片状脱发。其母孕期健康,父母非近亲结婚,无明显家族遗传性疾病,患儿智力正常。体检:消瘦,身高125cm,体重22kg,血压

关键词：患儿 hutchinson-gilford

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

幼年黄色肉芽肿合并hutchinson-gilford综合征一例

引用

天津医药 1991年第9期 538-538页

作者：王复仁罗喜玲刘兴贵金淑梅大连市中心医院

患儿男,1979年8月初诊,18个月,出生后2个月于颜面部发生数个米粒大、淡黄色或黄褐色结节,无明显症状,以后数目渐增多,向前胸蔓延,继而躯干四肢颈部被累及。患儿为第二胎、母乳喂养,父母健为非近亲婚配。体检:头无畸形,发黄稀疏,肝剑突下... 详细信息

患儿男,1979年8月初诊,18个月,出生后2个月于颜面部发生数个米粒大、淡黄色或黄褐色结节,无明显症状,以后数目渐增多,向前胸蔓延,继而躯干四肢颈部被累及。患儿为第二胎、母乳喂养,父母健为非近亲婚配。体检:头无畸形,发黄稀疏,肝剑突下3.5cm,肋下2.5cm,质较硬,脾未触及。躯干四肢

关键词：幼年黄色肉芽肿 hutchinson-gilford 综合征综合病症

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chemical screen identifies a geroprotective role of quercetin in premature aging

引用

Protein & Cell 2019年第6期10卷 417-435页

作者： Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellenee in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Jinan University Guangzhou 510632 China The MOH Key Laboratory of Geriatrics Beijing Hospital National Center of Gerontology Beijing 100730 China

Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in hutchinson-gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.

关键词： Quercetin Stem cell Aging Werner syndrome hutchinson-gilford progeria syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rheumatic Mineralization of Aortic Valve and Anterior Mitral Leaflet—A Case Report

引用

Case Reports in Clinical Medicine 2017年第4期6卷 95-119页

作者： Ramachandran Muthiah Thoothukudi Medical College Hospital Thoothukudi India

Aim: To present the heterotopic ossification of left-sided heart valves due to rheumatic inflammation and biomineralization. Introduction: Calcification in the region of mitral-aortic continuity is significant at its origin and etiopathogenesis. The etiology of valvular calcification may be divided into 3 groups, namely, inflammation, degeneration and metabolic disturbances. Calcification of cardiac valve leaflets is most often due to rheumatic etiology in tropical nations. Case Report: A 52-year-old male developed sudden onset of light-headedness and palpitations due to atrial fibrillation. Transthoracic 2D echocardiography revealed calcification of anterior mitral leaflet and aortic valve which resembles a bone-like structure and the patient was advised double valve replacement. Conclusion: It was known that the cellular mechanisms play an important role in its genesis and therapeutic strategies are targeted to reverse this process by understanding its biological mediators.

关键词： Rheumatic Mineralization Mitral-Aortic “J-Shaped” Calcification “Mushroom Shaped” Calcified Bicuspid Aortic Valve hutchinson-gilford Progeria Syndrome Therapeutic Strategies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：