检索结果-南通市图书馆

Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects

Cellular & Molecular Immunology 2022年第2期19卷 150-157页

作者： Jiaxin Zheng Yingying Deng Zhenyu Zhao Binli Mao Mengji Lu Yong Lin Ailong Huang Key Laboratory of Molecular Biology of Infectious Diseases(Chinese Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina. Institute for Virology University Hospital EssenUniversity of Duisburg-EssenEssen 45122Germany

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is an ongoing pandemic that poses a great threat to human health *** the humoral immune response plays essential roles in disease occurrence and development,understanding the dynamics and characteristics of virus-specific humoral immunity in SARS-CoV-2-infected patients is of great importance for controlling this *** this review,we summarize the characteristics of the humoral immune response after SARS-CoV-2 infection and further emphasize the potential applications and therapeutic prospects of SARSCoV-2-specific humoral immunity and the critical role of this immunity in vaccine ***,serological antibody testing based on the humoral immune response can guide public health measures and control strategies;however,it is not recommended for population surveys in areas with very low *** evidence suggests that asymptomatic individuals have a weaker immune response to SARS-CoV-2 infection,whereas SARS-CoV-2-infected children have a more effective humoral immune response than *** correlations between antibody(especially neutralizing antibody)titers and protection against SARS-CoV-2 reinfection should be further *** addition,the emergence of cross-reactions among different coronavirus antigens in the development of screening technology and the risk of antibody-dependent enhancement related to SARS-CoV-2 vaccination should be given further attention.

关键词： Antibody humoral immunity SARS-CoV-2 Serological antibody test Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impairment of cellular and humoral immunity in overweight Mongolian gerbils (Meriones unguiculatus)

引用

Integrative Zoology 2011年第4期6卷 352-365页

作者： Deli XU Xinyu LIU Dehua WANG State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina College of Life Sciences Qufu Normal UniversityQufuChina

Animal immunity is usually impaired in *** know little about the effect of being overweight or obese on the immune function of wild *** present study is aimed to test the hypothesis that immunity is suppressed in overweight Mongolian gerbils(Meriones unguiculatus).In the study,16 overweight(body mass:90.8-127.6 g)and 16 lean gerbils(body mass:60.5-77.7 g)were randomly selected from a total of 174 male gerbils(body mass range:55.8-144.7 g).Half of the overweight and lean males were injected with sterile saline;the others were immunochallenged(IC)with phytohaemagglutinin and keyhole limpet hemocyanin to assess cellular and humoral immunity,*** fat mass,wet and dry spleen mass,leukocyte counts,blood glucose levels and serum leptin levels were significantly higher in the overweight gerbils than in the lean ***,phytohemagglutinin response indicative of cellular immunity and immunoglobulin G concentrations was significantly lower in the IC overweight gerbils than in the IC lean *** results indicate that cellular and humoral immunity are impaired in the overweight *** body fat mass,higher leukocyte counts and serum leptin levels imply that overweight gerbils are in a low grade inflammatory state.

关键词： cellular immunity humoral immunity leptin Mongolian gerbils(Meriones unguiculatus) overweight

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous enhancement of cellular and humoral immunity by the lymph node-targeted cholesterolized TLR7 agonist liposomes

引用

Acta Pharmaceutica Sinica B 2024年第10期14卷 4577-4590页

作者： Dandan Wan Ziyi Bai Yu Zhang Li Chen Haiying Que Tianxia Lan Weiqi Hong Jiayu Huang Cai He Yuquan Wei Qiang Pu Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Department of Thoracic Surgery National Frontier Center of Disease Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Toll-like receptor(TLR)agonists,as promising adjuvants and immunotherapeutic agents,have the potential to enhance immune responses and modulate antigen-dependent T-cell immune memory through activation of distinct signaling ***,their clinical application is hindered by uncontrolled systemic inflammatory ***,it is imperative to create a vaccine adjuvant for TLR receptors that ensures both safety and *** this study,we designed lymph node-targeted cholesterolized TLR7 agonist cationic liposomes(1V209-Cho-Lip^(+))to mitigate undesired side ***-delivery of the model antigen OVA and cholesterolized TLR7 agonist facilitated DC maturation through TLR activation while ensuring optimal presentation of the antigen to CD8^(+)T *** main aim of the present study is to evaluate the adjuvant effectiveness of 1V209-Cho-Lip^(+)in tumor *** immunization with 1V209-Cho-Lip^(+)+OVA,we observed a pronounced"depot effect"and enhanced trafficking to secondary lymphoid *** vaccination with 1V209-Cho-Lip^(+)^(+)OVA significantly delays tumor development,prolongs mouse survival,and establishes durable immunity against tumor ***,1V209-Cho-Lip^(+)+OVA,while used therapeutic tumor vaccine,has demonstrated its efficacy in inhibiting tumor progression,and when combined with anti-PD-1,it further enhances antitumor ***,the co-delivery of antigen and lymph node-targeted cholesterolized TLR7 agonist shows great promise as a cancer vaccine.

关键词： TLR7 agonist Cationic liposomes Lymph node Cancer nanovaccines Immunotherapy Cross-presentation Cellular immunity humoral immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

COVID-ONE-hi:The One-stop Database for COVID-19-specific humoral immunity and Clinical Parameters

引用

Genomics, Proteomics & Bioinformatics 2021年第5期19卷 669-678页

作者： Zhaowei Xu Yang Li Qing Lei Likun Huang Dan-yun Lai Shu-juan Guo He-wei Jiang Hongyan Hou Yun-xiao Zheng Xue-ning Wang Jiaoxiang Wu Ming-liang Ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Hai-nan Zhang Huan Qi Siqi Yu Mingxi Lin Yandi Zhang Xiaosong Lin Zongjie Yao Huiming Sheng Ziyong Sun Feng Wang Xionglin Fan Sheng-ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Fujian Key Laboratory of Crop Breeding by Design Key Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350028China Department of Clinical Laboratory Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Public Health Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among *** immunity plays critical roles in SARS-CoV-2 infection and recovery from ***,differences in immune responses and clinical features among COVID-19 patients remain largely ***,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 *** addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the ***,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of *** the“START”button is clicked,one can readily obtain a comprehensive analysis report for further ***-ONE-hi is freely available at ***.

关键词： SARS-CoV-2 Protein microarray humoral immunity One-stop tool Shiny

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of soybean raffinose on growth performance,digestibility,humoral immunity and intestinal morphology of growing pigs

引用

Animal Nutrition 2021年第2期7卷 393-399页

作者： Zhu Zeng Yalin Zhang Jun He Jie Yu Xiangbing Mao Ping Zheng Yuheng Luo Junqiu Luo Zhiqing Huang Bing Yu Daiwen Chen Animal Nutrition Institute Sichuan Agricultural UniversityYa'an625014SichuanChina Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationYa'an625014SichuanChina

There are appreciable does of raffinose in soybean,but the impacts of raffinose on pigs are poorly *** used 2 experiments to investigate the influence of soybean raffinose on growth per-formance,digestibility,humoral immunity and intestinal morphology of growing *** Exp.1,a total of 30 crossbred(Duroc×Landrace×Yorkshire)barrows(21.93±0.43 kg)were randomly divided into 3 groups,and were fed with the control diet,the control diets supplemented with 0.2%and 0.5%raffinose,respectively,for 21 *** showed that the addition of 0.2%or 0.5%raffinose reduced(Phumoral immune response of growing pi

关键词： Soybean raffinose Growth performance Nutrient digestibility humoral immunity Pig

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Global dynamics in an age-structured HIV model with humoral immunity

引用

International Journal of Biomathematics 2021年第6期14卷 263-295页

作者： Zhongzhong Xie Xiuxiang Liu School of Mathematical Sciences South China Normal University Guangzhou 510631P.R.China

In this paper,we formulate an age-structured HIV model,in which the influence of humoral immunity and the infection age of the infected cells are *** model is governed by three ordinary differential equations and two first-ordered partial differential equations and admits three equilibria:disease-free,immune-inactivated and immune-activated *** introduce two important thresholds:the basic reproduction number R〇and immune-activated reproduction number R\and further show the global stability of above three equilibria in terms of R〇and Ri,*** numerical simulations are presented to illustrate our results.

关键词： humoral immunity age-structured HIV infection Lyapunov function global stability.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

B lymphocyte-mediated humoral immunity in the pathogenesis of chronic hepatitis B infection

引用

Liver Research 2020年第3期4卷 124-128页

作者： Jing Pan Tiantian Yao Hao Cheng Yan Zhu Yan Wang Department of Infectious Diseases Peking University First HospitalBeijingChina Department of Oncology Peking University First HospitalBeijingChina

During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:either the virus is cleared,or infection *** exhaustion of HBV-specific CD8^(+) cytotoxic T cells is the most important immune feature in chronic HBV ***,chronic HBV infection also re-writes humoral immunity,whereby B cells are the leading *** this review,we highlight HBV-specific B cell responses and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.

关键词： Hepatitis B virus(HBV) humoral immunity HBV-specific B cell Atypical memory B cell Cytokines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

STUDIES ON LYMPHOCYTE SUBSETS, humoral immunity AND THEIR RELATIONSHIP WITH SELENIUM IN PATIENTS WITH KASHIN-BECK DISEASE

引用

Journal of Pharmaceutical Analysis 2004年第1期16卷 35-38页

作者：王治伦郭汝宁陈静宏陈燕丁方羽吴劲周扬 Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong Vniversity) Ministry of Education

Objective To study the humoral immunity status and distribution pattern of lymphocyte subgroups of peripheral blood mononuclear cell (PBMC) in patients with Kashin-Beck Disease (KBD), and their relationship with erythrocyte selenium. Methods 23 X-ray diagnosed patients, 22 age- and sex- matched healthy children in KBD affected area (KAA), and 25 in KBD non-affected area (KNAA) were randomly selected. Immunohistochemistry with monoclonal antibodies anti-CD4, anti-CD8, anti-CD20 was conducted to analyze the lymphocyte subsets. Serum IgM, IgA, IgG, Complement C3 and C4 were assayed using rate nephelometry (Array 360 System, USA). The contents of erythrocyte selenium was determined by 2,3-diaminonaphthalene fluorescence assay. Results CD4+ and CD8+ cells percentage in PBMCs and serum IgA were significantly lower in KAA than those in KNAA(P 0.05) was found. Conclusion These results suggested that children in KAA had a comparably low cellular immunity level and their humoral immunity status was also in a state of moderate immune suppression. Of this immune disorder in Kashin-Beck disease patients, selenium deficiency probably played a critical role via affecting the distribution pattern of peripheral blood lymphocyte. Selenium-deficiency and immune impairment maybe both have something to do with the cause-effect chain of KBD.

关键词： Kashin-Beck disease humoral immunity lymphocyte subsets erythrocyte selenium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Combined Application of NRTUAs and ABP on Growth and humoral immunity of Chicks

引用

Asian Agricultural Research 2023年第1期15卷 47-49,57页

作者： Chao REN Ling GUI College of Animal Science and Veterinary Medicine Tianjin Agricultural University/Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy HusbandryTianjin 300384China

[Objectives]The paper was to study the effects of combined application of nonreplicating Toxoplasma uracil auxotrophs(NRTUAs)and Agaricus blazei Murill polysaccharide(ABP)on growth and humoral immunity of chicks.[Methods]A total of 120 one-day old female Hyline brown laying hens were randomly divided into 4 groups,30 hens for each *** chicks in group 1 were subcutaneously injected with NRTUAs and fed on the diet containing with ABP;the chicks in group 2 were subcutaneously injected with NRTUAs;the chicks in group 3 were subcutaneously injected with equal volume of PBS,and fed on the diet containing with ABP;the chicks in group 4 were subcutaneously injected with equal volume of *** body weight of chicks in each group was counted at the 21^(st),42^(nd),84^(th)and 112^(th)*** this period,blood samples were collected from chicks in each group at 0,7,14,21,28 and 35 d post immunization against Newcastle disease(ND),and serum was separated to detect the antibody titer of ND.[Results]The combined application of NRTUAs and ABP had no effect on growth of chicks,but promoted the humoral immune response of chicks,significantly improved the ND antibody level of chicks,and could maintain high levels of antibodies in the body for a long time.[Conclusions]The study lays a theoretical foundation for further developing the clinical application of NRTUAs and ABP.

关键词： NRTUAs ABP Chick Growth humoral immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Specific humoral immunity in Asymptomatic SARS-CoV-2 Infection

引用

Infectious Diseases & immunity 2021年第3期1卷 153-160页

作者： Yingying Deng Jiaxin Zheng Yong Lin Ailong Huang Key Laboratory of Molecular Biology of Infectious Diseases(Chinese Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing 400016China

The outbreak of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in December 2019 caused a huge blow to both global public health and global *** the early stage of the coronavirus disease 2019(COVID-19)epidemic,asymptomatic individuals with SARS-CoV-2 infection were ignored,without appropriate identification and ***,asymptomatic individuals proved to comprise a high proportion of all SARS-CoV-2-infected individuals,which greatly contributed to the rapid and wide spread of this *** this review,we summarize the latest advances in epidemiological characteristics,diagnostic assessment methods,factors related to the establishment of SARS-CoV-2 asymptomatic infection,as well as humoral immune features after SARS-CoV-2 infection or vaccination in asymptomatic individuals,which would contribute to effective control of ongoing COVID-19 epidemic.

关键词： Asymptomatic infection COVID-19 humoral immunity SARS-CoV-2 Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：