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Aging-independent and size-dependent genotoxic response induced by titanium dioxide nanoparticles in mammalian cells

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Journal of Environmental Sciences 2019年第11期31卷 94-106页

作者： Juan Wang Jingjing Wang Yun Liu Yaguang Nie Bo Si Tong Wang Ahmed Waqas Guoping Zhao Meimei Wang An Xu Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Chinese Academy of Sciences Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei Anhui 230031 P.R.China University of Science and Technology of China Hefei Anhui 230026 P.R.China Department of Pathophysiology Anhui Medical University Hefei Anhui 230032 P.R.China Institutes of Physical Science and Information Technology Anhui University Hefei Anhui 230601 P.R.China

Titanium dioxide nanoparticles (TiO2 NPs) are subjected to various transformation processes (chemical,physical and biological processes) in the environment,potentially affecting their bioavailability and toxic properties.However,the size variation of TiO2 NPs during aging process and subsequent effects in mammalian cells are largely unknown.The aim of this study was to illustrate the adverse effects of TiO2 NPs in different sizes (5,15 and human-hamster hybrid (AL) cells.There was an aging-time dependent enhancement of average hydrodynamic size in TiO2 NPs stock suspensions.The cytotoxicity of fresh TiO2 NPs increased in a size-dependent manner;in contrast,their genotoxicity decreased with the increasing sizes of NPs.No significant toxicity difference was observed in cells exposed to either fresh or 60 day-aged TiO2 NPs.Both Fresh and aged TiO2 NPs efficiently induced mitochondrial dysfunction and activated Caspase-3/7 in a size-dependent manner.Using mitochondrial-DNA deficient (ρ°) AL cells,we further discovered that mitochondrial dysfunction made significant contribution to the size-dependent toxicity induced by TiO2 NPs during the aging process.Taken together,our data indicated that TiO2 NPs could significantly induced the cytotoxicity and genotoxicity in an aging time-independent and size-dependent manner,which were triggered by mitochondrial dysfunction.Our study suggested the necessity to include size as an additional parameter for the cautious monitoring of TiO2 NPs disposal before entering the environment.

关键词： TiO2 NPs Aging process human-hamster hybrid (AL) cells Mitochondria Size-effects

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