检索结果-南通市图书馆

Identification of Age-associated Proteins and Functional Alterations in human retinal pigment epithelium

Genomics, Proteomics & Bioinformatics 2022年第4期20卷 633-647页

作者： Xiuxiu Jin Jingyang Liu Weiping Wang Jiangfeng Li Guangming Liu Ruiqi Qiu Mingzhu Yang Meng Liu Lin Yang Xiaofeng Du Bo Lei Henan Eye Institute Henan Eye HospitalPeople’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhou 450003China Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhou 450003China School of Medicine Henan Provincial People’s HospitalHenan UniversityZhengzhou 450003China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450001China School of Basic Medical Sciences Zhengzhou UniversityZhengzhou 450001China

retinal pigment epithelium(RPE)has essential functions,such as nourishing and supporting the neural retina,and is of vital importance in the pathogenesis of age-related retinal ***,the exact molecular changes of RPE during aging remain poorly ***,we isolated human primary RPE(h RPE)cells from 18 eye donors distributed over a wide age range(10–67 years old).A quantitative proteomic analysis was performed to analyze changes in their intracellular and secreted ***-group related subtypes and age-associated proteins were revealed and potential age-associated mechanisms were validated in ARPE-19 and h RPE *** results of proteomic data analysis and verifications suggest that RNF123-and RNF149-related protein ubiquitination plays an important role in protecting h RPE cells from oxidative damage during *** older h RPE cells,apoptotic signaling-related pathways were up-regulated,and endoplasmic reticulum organization was down-regulated both in the intracellular and secreted *** work paints a detailed molecular picture of h RPE cells during the aging process and provides new insights into the molecular characteristics of RPE during aging and under other related clinical retinal conditions.

关键词： human retinal pigment epithelium Proteomics Aging Retina Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：