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Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia

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World Journal of stem cells 2022年第9期14卷 714-728页

作者： Xu-Dong Feng Jia-Hang Zhou Jun-Yao Chen Bing Feng Rui-Tian Hu Jian Wu Qiao-Ling Pan Jin-Feng Yang Jiong Yu Hong-Cui Cao State Key Laboratory for The Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Chemistry Duke UniversityDurhamNC 27708United States Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117Shandong ProvinceChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The effect of hypoxia on mesenchymal stem cells(MSCs)is an emerging topic in MSC *** long non-coding RNAs(lncRNAs)and messenger RNAs(mRNAs)are reported to play a critical role in regulating the biological characteristics of MSCs,their specific expression and co-expression profiles in human placenta-derived MSCs(hP-MSCs)under hypoxia and the underlying mechanisms of lncRNAs in hP-MSC biology are *** To reveal the specific expression profiles of lncRNAs in hP-MSCs under hypoxia and initially explored the possible mechanism of lncRNAs on hP-MSC *** Here,we used a multigas incubator(92.5%N_(2),5%CO_(2),and 2.5%O_(2))to mimic the potential of *** sequencing technology was applied to identify the exact expression profiles of lncRNAs and mRNAs under *** We identified 289 differentially expressed lncRNAs and 240 differentially expressed mRNAs between the hypoxia and normoxia *** them,the lncRNA SNHG16 was upregulated under hypoxia,which was also validated by reverse transcription-polymerase chain ***16 was confirmed to affect hP-MSC proliferation rates using a SNHG16 knockdown ***16 overexpression could significantly enhance the proliferation capacity of hP-MSCs,activate the PI3K/AKT pathway,and upregulate the expression of cell cycle-related *** Our results revealed the specific expression characteristics of lncRNAs and mRNAs in hypoxiacultured hP-MSCs and that lncRNA SNHG16 can promote hP-MSC proliferation through the PI3K/AKT pathway.

关键词： human placenta-derived mesenchymal stem cell Hypoxia Long non-coding RNAs Proliferation mesenchymal stem cell

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