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Role of human nucleoside transporters in pancreatic cancer and chemoresistance

World Journal of Gastroenterology 2021年第40期27卷 6844-6860页

作者： Carly Jade Carter Ahmed H Mekkawy David L Morris Hepatobiliary and Surgical Oncology Unit Department of SurgerySt George HospitalUniversity of New South WalesSydney 2217New South WalesAustralia Mucpharm Pty Ltd Australia

The prognosis of pancreatic cancer is poor with the overall 5-year survival rate of less than 5%changing minimally over the past decades and future projections predicting it developing into the second leading cause of cancer related mortality within the next *** into the mechanisms of pancreatic cancer development,progression and acquired chemoresistance have been constant for the past few decades,thus resulting in the identification of human nucleoside transporters and factors affecting cytotoxic uptake via said *** review summaries the aberrant expression and role of human nucleoside transports in pancreatic cancer,more specifically human equilibrative nucleoside transporter 1/2(hENT1,hENT2),and human concentrative nucleoside transporter 1/3(hCNT1,hCNT3),while briefly discussing the connection and importance between these nucleoside transporters and mucins that have also been identified as being aberrantly expressed in pancreatic *** review also discusses the incidence,current diagnostic techniques as well as the current therapeutic treatments for pancreatic ***,we address the importance of chemoresistance in nucleoside analogue drugs,in particular,gemcitabine and we discuss prospective therapeutic treatments and strategies for overcoming acquired chemoresistance in pancreatic cancer by the enhancement of human nucleoside transporters as well as the potential targeting of mucins using a combination of mucolytic compounds with cytotoxic agents.

关键词： Pancreatic cancer Gemcitabine human nucleoside transporters human equilibrative nucleoside transporters human concentrative nucleotide transporters Mucins

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