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Multimodality treatment of potentially curative gastric cancer: Geographical variations and future prospects

World Journal of Gastroenterology 2014年第36期20卷 12892-12899页

作者： Neil D Merrett Discipline of Surgery School of Medicine University Of Western Sydney Penrith NSW 2751 Australia Department of Upper Gastrointestinal Surgery Sydney South West Local Health District Liverpool NSW 2170 Australia

After much controversy, multimodality therapy is now accepted worldwide as the gold standard for treatment of resectable bulky localized gastric cancer. There is significant regional variation in the style of multimodality treatment with adjuvant chemoradiation the North American standard, neoadjuvant chemotherapy preferred in Europe and Australasia, whilst adjuvant chemotherapy is preferred in Asia. With further standardization of surgery and D1+/D2 resections increasingly accepted world wide, and in particular in the West, as the surgical standard of care for potentially curable disease, it is timely to reassess the multimodality regimes being used. The challenge in the use of multimodality therapy is how current outcomes can be standardized and improved further. Recent studies indicate that mere intensification of the regime in time, dosage or addition of further agents does not improve localized gastric cancer outcomes. More novel strategies including early commencement of adjuvant therapies, intra-peritoneal chemotherapy or assessing neoadjuvant response with positron emission tomography scanning may give improvements in outcomes. The introduction of targeted therapies means that the adjuvant use of biological agents needs to be explored. By proper assessment of the patient’s co-morbidities, full tumour staging, and a better understanding of the tumour’s molecular pathology, multimodality therapy for gastric adenocarcinoma may be individualized to optimize the likelihood of cure.

关键词： Gastric cancer Gastrectomy Multimodality Adjuvant treatment Neoadjuvant Targeted therapy human epidermal growth factor receptor

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Single-domain antibodies for radio nuclear imaging and therapy of esophageal squamous cell carcinoma:a narrative review

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Journal of Bio-X Research 2020年第4期3卷 135-143页

作者： Huifang Liu Xu Nie Zhenchao Tian Dan Chen Xueli Chen Qi Zeng Xinyi Xu Engineering Research Center of Molecular and Neuroimaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’anShaanxi ProvinceChina

Single-domain antibodies have the characteristics of small molecular weight,strong tissue penetration,and high affinity,and are widely used to construct molecular probes for disease diagnosis and *** article reviews molecular imaging studies including positron emission tomography(PET),single-photon emission computed tomography/computed tomography(CT),PET/CT,and fluorescent imaging of molecular probes composed of single-domain antibodies against eight esophageal squamous cell carcinoma biological *** 8 targets are highly expressed on the membrane of esophageal squamous cell carcinoma cells and include epidermal growth factor receptor,human epidermal growth factor receptor 2,human epidermal growth factor receptor 3,hepatocyte growth factor receptor,vascular endothelial growth factor receptor 2,chemokine receptor 4,chemokine receptor 7,and carcinoembryonic *** current problems and solutions are also discussed to provide a reference for future design of molecular imaging probes targeting esophageal squamous cell carcinoma.

关键词： esophageal squamous cell carcinoma hepatocyte growth factor receptor human epidermal growth factor receptor molecular imaging single-domain antibody

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