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Calcium carbonate nanoparticles promote osteogenesis compared to adipogenesis in human bone-marrow mesenchymal stem cells

引用

Progress in Natural Science:Materials International 2018年第5期28卷 598-608页

作者： Xiaoning Li Xing Yang Xujie Liu Wei He Qianli Huang Shengrong Li Qingling Feng School of Earth Science and Resources China University of Geosciences State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Graduate School at Shenzhen Tsinghua University School of Materials Science and Engineering University of Science and Technology Beijing Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and Engineering Tsinghua University

Rhombohedron-like and fusiform calcium carbonate nanoparticles were fabricated using a new method. Their geometry was controlled by varying the mixing speed and ratio of ethanol versus water in reaction system. The calcium carbonate nanoparticles(CCNPs) have slight effect on viability of human bone-marrow mesenchymal stem cells(hBMSCs) with dose-dependent and shape-dependent, but they can significantly promote osteogenic differentiation of hBMSCs in vitro by 10–37% increase of alkaline phosphatase(ALP) activity, 9–36% growth of collagen secretion and 1.13–1.83 folds upregulation of osteogenesis-related genes, even at lower dose ranges(5–20 μg/ml). The efficacity of promoting osteogenesis depends on the shape and dose of CCNPs. Furthermore,adipogenesis was inhibited by less accumulation of lipid droplets, lower triglyceride(TG) secretion and downregulation of adipogenesis-related genes. These findings improve the understanding of effects CCNPs on hBMSCs fate towards osteoblasts or adipocytes and have meaningful impact for combining use of CCNPs and hBMSCs in tissue engineering and regenerative medicine fields.

关键词： human bone-marrow mesenchymal stem cells Calcium carbonate nanoparticles Osteogenesis Adipogenesis

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