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Neuro-regenerative imidazole-functionalized GelMA hydrogel loaded with hAMSC and SDF-1α promote stem cell differentiation and repair focal brain injury

引用

Bioactive Materials 2021年第3期6卷 627-637页

作者： Yantao Zheng Gang Wu Limei Chen Ying Zhang Yuwei Luo Yong Zheng Fengjun Hu Tymor Forouzanfar Haiyan Lin Bin Liu Emergency Department Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Oral Implantology and Prosthetic Dentistry Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam(UvA)and Vrije Universiteit Amsterdam(VU)AmsterdamNetherlands Department of Emergency Guangzhou Red Cross HospitalMedical CollegeJinan UniversityGuangzhou City510220China Rheumatology Department The Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Emergency Medicine Department Qingxin Section of Qingyuan People's HospitalQingyuanChina Institute of Information Technology Zhejiang Shuren UniversityHangzhouChina Department of Oral and Maxillofacial Surgery/Pathology Amsterdam UMC and Academic Center for Dentistry Amsterdam(ACTA)Vrije Universiteit AmsterdamAmsterdam Movement Sciencede Boelelaan1117AmsterdamNetherlands Savaid Stomatology School Hangzhou Medical CollegeHangzhouChina

Brain tissues that are severely damaged by traumatic brain injury(TBI)is hardly regenerated,which leads to a cavity or a repair with glial ***-cell therapy is one viable option to treat TBI-caused brain tissue damage,whose use is,whereas,limited by the low survival rate and differentiation efficiency of stem *** approach this problem,we developed an injectable hydrogel using imidazole groups-modified gelatin methacrylate(GelMA-imid).In addition,polydopamine(PDA)nanoparticles were used as carrier for stromal-cell derived factor-1(SDF-1α).GelMA-imid hydrogel loaded with PDA@SDF-1αnanoparticles and human amniotic mesenchymal stromal cells(hAMSCs)were injected into the damaged area in an in-vivo cryogenic injury model in *** hydrogel had low module and its average pore size was 204.61±41.41 nm,which were suitable for the migration,proliferation and differentiation of stem ***-vitro cell scratch and differentiation assays showed that the imidazole groups and SDF-1αcould promote the migration of hAMSCs to injury site and their differentiation into nerve *** highest amount of nissl body was detected in the group of GelMA-imid/SDF-1α/hAMSCs hydrogel in the in-vivo ***,histological analysis showed that GelMA-imid/SDF-1α/hAMSCs hydrogel could facilitate the regeneration of regenerate endogenous nerve *** summary,the GelMA-imid/SDF-1α/hAMSCs hydrogel promoted homing and differentiation of hAMSCs into nerve cells,and showed great application potential for the physiological recovery of TBI.

关键词： Injectable hydrogel Imidazole stromal-cell derived factor-1(SDF-1α) human amniotic mesenchymal stromal cells (hAMSCs) Brain injury

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