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huatan qushi formula alleviates non-alcoholic fatty liver disease via PI3K/Akt signaling and gut microbiota modulation

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Journal of Traditional Chinese Medical Sciences 2024年第4期11卷 443-455页

作者： Xiuping Zhang Linghui Zhu Jinchen Ma Yi Zheng Xuejing Yang Lingling Yang Yang Dong Yan Zhang Baoxing Liu Lingru Li Department of Gynecology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Memorial Sloan Kettering Cancer Center 1275 York AvenueNew YorkNY 10065USA Department of Hepatobiliary Spleenand Stomach DiseasesHenan Province Hospital of TCMZhengzhou450002China Monitoring and Statistical Research Center National Administration of Traditional Chinese MedicineBeijing100027China National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing100029China Department of Andrology China-Japan Friendship HospitalBeijing100029China a r t i c l e i n f o Article history:Received 21 May 2024 Received in revised form 29 August 2024 Accepted 31 August 2024 Available online 6 September 2024 Keywords:Non-alcoholic fatty liver disease Huatan Qushi formula Network pharmacology PI3K/Akt signaling pathway 16S rRNA sequencing Gut microbiota

Objective:To provide the mechanism-based pharmacotherapy of the huatan qushi formula(HTQS for-mula),for the health management and treatment of non-alcoholic fatty liver disease(NAFLD).Methods:A rat model of NAFLD was employed to examine the efficacy and safety of the HTQS *** vivo active components and potential mechanisms of the HTQS formula were identified using UPLC‒MS/MS combined with network *** influence of the HTQS formula on the dominating proteins in PI3K/Akt pathway was validated in vivo using western ***,16S rRNA sequencing of the gut microbiome was conducted followed by targeted metabolomics detecting fecal short-chain fatty acids(SCFAs)and bile acids to determine the impact of the HTQS formula on gut ***:The HTQS formula reduced weight gain and hepatic steatosis in NAFLD rats and decreased serum total cholesterol(TC),triglycerides,blood glucose,and insulin resistance(IR)without causing liver or kidney *** detected 28 components using UPLC‒MS/MS and identified 439 shared targets be-tween NAFLD and the HTQS ***,we focused on the PI3K/Akt signaling pathway based on protein‒protein interaction network *** validated that the HTQS formula inhibited liver stea-tosis and inflammation by increasing the phosphorylation levels of PI3K,AKT,P27,GSK3b in the PI3K/Akt signaling pathway.16S rRNA sequencing revealed that the HTQS formula reduced the abundance of the genus Family_XIII_AD3011_group,which was positively correlated with IR and taurodeoxycholic *** addition,Lachnospiraceae_UCG_010 inversely correlated with TC and five bile acids,which could be essential to the therapeutic effect of the HTQS formula against ***:The HTQS formula proved to be an effective pharmacotherapy for NAFLD without causing liver or kidney *** potent components of the HTQS formula could alleviate liver steatosis and lipid metabolism disorder by modulating the PI3K/Akt signaling pathway an

关键词： Non-alcoholic fatty liver disease huatan qushi formula Network pharmacology PI3K/Akt signaling pathway 16S rRNA sequencing Gut microbiota

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