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Efficacy and safety of huangqi jianzhong decoction in the treatment of chronic atrophic gastritis:A meta-analysis

World Journal of Clinical Cases 2023年第24期11卷 5710-5720页

作者： Xin-Peng Yan Wen Si Ming-Sheng Ding Yuan-Fen Tian Zhuang Guo Department of Traditional Chinese Medicine Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Endocrinology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Children’s Rehabilitation and Health Care Department Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina Department of Gastroenterology Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina

BACKGROUND Chronic atrophic gastritis is a persistent disorder of the digestive system where the gastric mucosa epithelium and glands undergo atrophy,leading to a decrease in their number and thinning of the gastric *** is worth noting that the prevalence of chronic atrophic gastritis is higher in China compared to the global average,and it is also considered a precancerous condition for gastric *** To evaluate the efficacy of huangqi jianzhong decoction in treating chronic atrophic *** atrophic gastritis is a persistent illness characterized by the progressive disappearance of healthy gastric glands due to repeated *** jianzhong decoctions are widely used in China to treat chronic atrophic ***,there is limited scientific evidence regarding their efficacy in treating this *** The present meta-analysis adhered to the PRISMA guidelines and used the Cochrane Collaboration *** performed a comprehensive search for clinical trials investigating the use of huangqi jianzhong decoction in treating chronic atrophic gastritis published until January *** risk of bias and the quality of the included studies were evaluated using the Cochrane Handbook ***,a meta-analysis was conducted using the RevMan 5.4 softRESULTS This study included a total of 13 articles,comprising 1269 *** meta-analysis was conducted on these 13 articles,yielding the following results:I2=0%,P=0.60,[RR=1.24,95%CI:1.18 to 1.30,P<0.00001].The forest plot analysis of the Helicobacter pylori clearance rate revealed I2=0%,P=0.36,[RR=1.20,95%CI:1.05 to 1.38,P=0.009].The forest plot of PG-I level showed I2=99%,P<0.00001,[MD=4.99,95%CI:-1.59 to 11.58,P=0.14].The forest plot of stomach pain demonstrated I2=54%,P=0.04,[MD=-0.63,95%CI:-0.68 to-0.58,P<0.00001].The forest plot of reflux indicated I2=82%,P=0.0009,[MD=-0.48,95%CI:-0.63 to-0.33,P<0.00001].The forest plot of recurrence rate exhibited I2=0%,P=0.92,[RR=0.15,95

关键词： Meta-analysis Chronic atrophic gastritis huangqi jianzhong decoction Safety

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