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Components of traditional Chinese medicine inhibit platelet aggregation by blocking ADP receptor subtypes P2Y1 and P2Y12

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中国药理学与毒理学杂志 2015年第S1期29卷 28-29页

作者： Xiao-liangWANG Yi-yingLI Hong-yanYANG ShaofengXU LingWANG Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050 China

Platelets aggregation and thrombosis formation are major reasons of cardiovascular and cerebral vascular *** develop new generative,potent and safe agents for inhibiting platelet aggregation and preventing above diseases are urgently *** traditional Chinese medicines of″houxue Huayu″have been shown to inhibit platelet aggregation *** the present study the mechanisms and the molecular targets of puerarin,salvianolic acid B and the analogue of 3-n-butylphthalide,dl-PHPB were investigated and compared with *** platelet aggregation inducers,ADP,arachidonic acid,collagen and thrombin were used in the *** was found that puerarin and dl-PHPB specifically inhibited ADP induced platelet aggregation like ticlopidine ***,salvianolic acid B inhibited both ADP and collagen induced platelet aggregations with similar *** to existing two ADP receptor subtypes on platelets,P2Y1 and P2Y12,we studied the action of above compounds on the receptors and the signaling *** was found that dl-PHPB decreased IP1 accumulation produced by ADP,but had no effect on IP1 level induced by m-3M3 FBS,an activator of PLC.M-3M3 FBS might attenuate the inhibitory effect of dl-PHPB on ADP-induced platelet *** addition,dl-PHPB did not affect cyclic AMP formation in platelets by ADP,which is different from P2Y12 antagonist *** showed the similar effects of ***,the actions of dl-PHPB and puerarin might be through P2Y1receptor-PLC-β*** acid B did not reduce the IP1 accumulation stimulated by *** might act on the receptor subtype *** results suggest that components of Chinese herb medicine might be a resource for development of novel anti-platelet drugs.

关键词： platelet aggregation ADP receptors houxue Huayu

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