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Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities

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Acta Pharmaceutica Sinica B 2018年第2期8卷 218-227页

作者： Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen Department of Pharmacognosy School of Pharmacy Fudan University Department of Pharmacology School of Pharmacy Fudan University

Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the "two-hit" ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata.

关键词： Houttuynia cordata Polysaccharides Fever Acute lung injury Anti-complementary

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Structures,Components and Functions of Secretory Tissues in Houttuynia cordata

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Journal of Integrative Plant Biology 2007年第12期49卷 1734-1745页

作者： Xi-Lu Ni Li Peng Wen-Zhe Liu College of Life Sciences Northwest University Xi'an 710069 China College of Life Sciences Ningxia University Yinchuan 750021 China

Houttuynia cordata Thunb., traditionally used as a therapeutic plant in folk medicine, has shown antioxidant and anticancer activities. The species, as a core component of paleoherbs, is normally characterized based on the presence of different types of secretory tissue： oil cells, three types of secretory cells and glandular hairs. The aim of this work was to study the structural, componential, and the functional characteristics of the secretory tissues in both the floral and vegetative parts. The results indicate that oil cells and secretory cells are distributed in all organs of the plant, while glandular hairs are situated on the aerial stems and leaves. Both oil cells and glandular hairs initiate from the protoderm, but their developmental processes are different. Although three types of secretory cells initiate from different primary meristems, the developmental patterns of different secretory cells are the same. Also, although the origins of secretory cells are different from oil cells, their early developmental processes are the same. Histochemical results show that oil cells, secretory cells and glandular hairs produce flavonoids, phenolic compounds, tannins, lipids, aldehyde and ketone-compounds. In addition, there are terpenoids and pectic-like substances in oil cells, alkaloids in secretory cells of aerial stems, and terpenoids and alkaloids in glandular hairs. These compounds play very important roles in protecting plants from being eaten by herbivores （herbivory） and infected by microbial pathogens. The oil cell and secretory cell, as unicellular secretory tissues, are intermediates between the primitive surface glandular and secretory cavity and canal during the evolution of secretory structures.

关键词： components functions glandular hairs Houttuynia cordata oil cells secretory ceils secretory tissues structures.

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Isolation and Identification of Houttuynia cordata Endophytic Bacteria and Study of Antibiotic Activity

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Medicinal Plant 2023年第3期14卷 1-4页

作者： Kaifeng WANG Shunxin YANG Zhannan YANG Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment of Guizhou Province Guizhou Normal UniversityGuiyang 550001China School of Life Science Guizhou Normal UniversityGuiyang 550001China

[Objectives]To further explore the resources of biocontrol strains and provide new options for the control of pathogenic bacteria.[Methods]Houttuynia cordata endophytic bacteria were isolated and identified,and the antibiotic activity was explored.[Results]There are 8 strains(H1-H8)of endophytic bacteria isolated from the healthy plants of H.cordata,which had an antagonistic effect on the pathogenic bacteria.According to the gene sequence,the 8 strains were identified as Stenotrophomonas,Pseudomonas,and Bacillus,which strongly inhibited Colletotrichum(HC1),Fusarium(HC2),and Rhizoctonia(HC5)of H.cordata.On the PDA culture dish,the inhibition diameter of the 8 strains on Colletotrichum,Fusarium,and Rhizoctonia was 6,8,and 5 mm,respectively.[Conclusions]Pathogenic bacteria and endophytic bacteria inoculated with H.cordata seedlings showed that endophytic bacteria have certain antagonistic activity,and have the potential for development and application.

关键词： Houttuynia cordata Endophytic Bacteria Pathogenic bacteria Antibiotic

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Network pharmacology-based analysis on three amicoumacin-type isocoumarin compounds from an endophytic bacterium in Houttuynia cordata

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Asian Journal of Traditional Medicines 2021年第5期16卷 255-268页

作者： Yiyao Lu Yinjie Xiong Mengyue Zhang Yingying Wu Jingjing Xu Linyu Zhang Xin Wu School of life science and biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Amicoumacin isocoumarin-type compounds are mainly derived from the secondary metabolites of Bacillus bacteria,and have potential biological activities such as antibacterial,anti-tumor,anti-inflammatory,and anti-ulcer.In our previous research,three amicoumacin-type isocoumarin compounds,Paenicoumacin A,Paenicoumacin B,and Paenicoumacin C(B and C are novel),were isolated from an endophytic bacterium in Houttuynia cordata.In this study,network pharmacology and bioinformatics techniques were used to analyze the potential activities of amicoumacin compounds in the treatment of liver cancer.These compounds were found to mainly regulate cellular oxidative stress,cancer process,nucleic acid metabolism,nutritional metabolism and other pathways.The findings provide useful information for subsequent experimental verification.

关键词： Houttuynia cordata Paenibacillus isocoumarin liver cancer network pharmacology

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Determination of Total Flavonoids and Its Antioxidant Ability in Houttuynia cordata

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Journal of Materials Science and Chemical Engineering 2016年第2期4卷 131-136页

作者： Anyin Chen Wenjun Xiang Dan Liu Changlu Liu Li Yang Key Laboratory of Exploitation and Study of Distinctive Plants in Education Department of Sichuan Province Sichuan University of Arts and Science Dazhou China Department of Chemistry and Chemical Engineering Sichuan University of Arts and Science Dazhou China

The total flavonoids of Houttuynia cordata are determined by UV-Vis spectrophotometry. The ex-traction condition of flavonoids from Houttuynia cordata includes: the extraction temperature is 70℃, solid-liquid ratio is 1:20, solvent is 80% ethanol, extraction time is 65 min. We studied the antioxidation of flavonoids in Houttuynia cordata, and results showed that flavonoids had strong reducing capacity, hydroxyl free radical scavenging activity and the superoxide anion radical scavenging ability, thus can provide a basis for the development of natural antioxidants.

关键词： Houttuynia cordata Total Flavonoids Antioxidant Capacity

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