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Risk factors for pertussis among children hospitalized for pertussis during 2016-2017, in Guizhou Province of China: a case-control study

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Global Health Journal 2021年第2期5卷 97-101页

作者： Feng Jiang Keli Li Guangpeng Tang Yan Huang Guizhou Center for Disease Control and Prevention Institute of Expanded Programme on ImmunizationGuiyang 550004China Chinese Center for Disease Control and Prevention Center for National Immunization ProgramBeijing 102206China Guizhou Centre for Disease Control and Prevention Institute of Communicable Disease Control and PreventionGuiyang 550004China

Aim:Pertussis is a respiratory tract infection,the vaccine for which was introduced in the Expanded Programme on Immunization(EPI)in Guizhou Province of China(hereafter referred as Guizhou)in the *** vaccine rapidly decreased incidence rates of pertussis in the province,however,despite the wide high coverage of the diphtheria,tetanus and acellular pertussis(DTaP)combined vaccine,there has been a resurgence of pertussis since *** with this recent increase in disease transmission,risk factors for pertussis infection have not been evaluated in *** aimed to provide information on pertussis risk factors and insight on designing targeted pertussis control policies and measures through this ***:A 1:2 matched retrospective case-control study was conducted between 2016 and 2017,involving infants and children younger than 6 years old and parents of the *** enrolled cases included clinical and laboratory confirmed pertussis cases according to the WHO-recommended pertussis *** were selected from children in the same neighborhood who were not diagnosed with pertussis prior to our investigation and did not exhibit any clinical manifestations of ***:The household size[Matched odds ratio(OR_(m)=1.4,95%confidence interval(Cl):1.1-1.7]and household members with antecedent cough(OR_(m)=3.6,95%CI:1.8-7.2)were significantly associated with their child’s pertussis *** parents’occupations were significantly associated with their child’s pertussis onset(ORm=9.4,95%CI:1.6-54.8,for mother side;ORm=4.5,95%CI:1.2-16.5,for father side),when they worked in the business and/or service *** family members with a history of cough was an independent risk factor for pertussis[Adjusted odds ratio(AOR)=43.6,95%CI:2.7-694.0].Besides,the parents’demographic characteristics and DTaP doses were not found to be independent ***:household exposure is an important risk factor for pertussis infection in infa

关键词： Pertussis risk factors household exposure Guizhou province China Pertussis resurgence Diphtheria Tetanus and acellular pertussis combined vaccine

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