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Impact of gonadotropin-releasing hormone agonist and hormone replacement therapy on pregnancy outcomes in single euploid frozen-thawed embryo transfer for patients with endometrial polyps

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生殖与发育医学(英文) 2024年第1期08卷 1-7页

作者： Zhao Qing Li Jie Wang Wei-Lin Liu Ying-Bo Li Jing Ni Tian-Xiang Zhou Wei Zhang Qian Yan Jun-Hao Center for Reproductive Medicine Shandong University 3. Jinan 250012 4. China

Objective: Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) is lacking, this is particularly true for patients with infertility and a history of endometrial polyps (EPs). In this study, we aimed to investigate whether a gonadotropin-releasing hormone agonist combined with hormone replacement therapy (GnRHa-HRT) could improve pregnancy outcomes in single euploid FET for patients with a history of ***: In this retrospective cohort study, 395 women who underwent their first single euploid FET cycle were divided into groups according to endometrial preparation protocols as follows: natural cycle (NC) (n = 220), hormone replacement therapy (HRT) (n = 122), and GnRHa-HRT groups (n = 53). Subsequently, the FET cycles in the three groups were subdivided according to maternal age. All patients underwent hysteroscopic polypectomy before FET, and their EPs were confirmed by ***: No statistically significant differences were observed in live birth rates among the three groups (58.64%vs. 58.20%vs. 56.60%,P = 0.964). Furthermore, the rates of miscarriage, ectopic pregnancy, premature live birth, and pregnancy complications were comparable among the three groups (P >0.05). After adjusting for potential confounding factors, no significant differences in pregnancy outcomes were reported between the groups (adjusted odds ratios [OR] and 95% credible intervals [CI] for live birth rate, HRTvs. NC: 1.119, 0.660–1.896,P = 0.677; GnRHa-HRTvs. NC: 1.165, 0.610–2.226,P = 0.643). Additionally, the pregnancy outcomes of the FET cycle were not influenced by the endometrial preparation protocols in the subgroups when stratified by maternal age (P >0.05).Conclusion: GnRHa-HRT did not improve the pregnancy outcomes of the single euploid FET in patients with a history of EPs.

关键词： Endometrial polyps Frozen-thawed embryo transfer GnRHa hormone replacement therapy Preimplantation genetic testing

Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed Paige Deville Blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan Marr Anil Paramesh Alison A Smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with Phormone therapies used(P>0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine hormone replacement therapy Steroids Organ donor Retrospective

Attributable Causes of Breast Cancer and Ovarian Cancer in China:Reproductive Factors,Oral Contraceptives and hormone replacement therapy

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Chinese Journal of Cancer Research 2012年第1期24卷 9-17页

作者： Li Li Jia JI Jian-bing Wang Mayineur Niyazi You-lin Qiao Paolo Boffettas Deportment of Gynecology the People's Hospitul of Xinjiung Uygur Autonomous RegionUrumqi 830011China Department of Cancer Epidemiology Cancer InstituteChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Division of Pharmaceutics College of Pharmacythe Ohio State UniversityColumbusOH 43210USA Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100730China The Tisch Cancer Institute Mount Sinai School of MedicineNew YorkNY 10029USA International Prevention Research Institute Lyon 69006France

Objective： To provide an evidence-based, consistent assessment of the burden of breast cancer attributable to reproductive factors （RFs, including nulliparity, mean number of children, age at first birth and breastfeeding）, use of oral contraceptives （OCs, restricted to the age group of 15-49 years）, and hormone replacement therapy （HRT）, as well as of the burden of ovarian cancer attributable to the mean number of children in China in 2005. Methods： We derived the prevalence of these risk factors and the relative risk of breast and ovarian cancer from national surveys or large-scale studies conducted in China. In the case of RFs, we compared the exposure distributions in 2001 and counterfactual exposure. Results： Exposure of RFs in 2002 was found to account for 6.74% of breast cancer, corresponding to 9,617 cases and 2,769 deaths, and for 2.78% of ovarian cancer （712 cases, 294 deaths）. The decrease in mean number of children alone was responsible for 1.47% of breast cancer and 2.78% of ovarian cancer. The prevalence of OC use was 1.74% and the population attributable fraction （PAF） of breast cancer was 0.71%, corresponding to 310 cases and 90 deaths. The PAF of breast cancer due to HRT was 0.31%, resulting in 297 cases and 85 deaths. Conclusion： RFs changes in China contributed to a sizable fraction of breast and ovarian cancer incidence and mortality, whereas HRT and OCs accounted for relatively low incidence of breast cancer in China.

关键词： Reproductive factors Oral contraceptives hormone replacement therapy Cancer Population attributable fraction

Postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas

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Chinese Medical Journal 2008年第20期121卷 2077-2082页

作者： LI Gui-mei SUN Xiao-jun SHAO Peng Department of Pediatrics Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China

Background The proliferative activity and penetration into the hypothalamic structures in children craniopharyngiomas （CP） often make radical resection difficult. Therefore, complete resection of CP often results in permanent multiple pituitary hormone deficiency （MPHD）. This study aimed to elucidate the postoperative pituitary hormonal disturbances, and hormone replacement therapy （HRT） time and dosage in children with CP. Methods Twenty patients with growth retardation and CP after resection, comprising 14 boys and 6 girls, with a mean age of （10.63±3.18） years （Group A） and 10 male patients of group A aged 〉10 years （Group B） were entolled. Thirty age-, sex- and Tanner stage-matched normal children （control Group A）, and 44 male older children 〉10 years （control Group B） served as controls. The serum concentrations of insulin-like growth factor-1 （IGF-1）, growth hormone （GH）, free thyroxine （FT4）, thyroid-stimulating hormone （TSH）, adrenocorticortropic hormone （ACTH）, cortisol （COR）, follicle stimulating hormone （FSH）, luteinizing hormone （LH）, prolactin （PRL）, testosterone （T） and estradiol （E2） were measured in the CP patients after resection and in controls. The appropriate time and dosage of HRT were investigated. Linear correlation analysis was made between levothyroxine （L-T4） dosage and primary FT4 in CP patients after resection. Results All cases had MPHD. The serum peak GH, IGF-1, FT4 and COR levels of Group A were significantly lower than that of the control Group A. The serum IGF-1 concentration increased to the normal level after 3 months of rhGH therapy; the serum FSH, LH, and T levels were significantly decreased （P 〈0.001）; however, E2 and PRL were significantly increased （P 〈0.001） in Group B compared with the control Group B; 18 cases were found to have central diabetes insipidus （DI） by water deprivation test and MRI. There was a significant negative linear regression （r=-0.8, P 〈0.001） between L-T4 and primary FT4 in Group A patients with C

关键词： craniopharyngiomas postoperative children multiple pituitary hormone deficiency hormone replacement therapy

Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 12-17页

作者： Barbara RUSZKOWSKA GraZyna GADOMSKA Liliana BIELIS Marzena GRUSZKA Barbara GóRALCZYK Danuta RO GraZyna ODROWAZ-SYPNIEWSKA Department of Pathophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone,the combination of doses,the time of taking HRT,and the route of administration (oral,transdermal,implanted).The aim of the current study was to assess some parameters of coagulation,especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal ***: The study was conducted on 76 healthy women,including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT,and 30 women aged 44–54 years who did not take HRT as the control *** concentrations of TF,TFPI,thrombin-antithrombin complex (TAT),and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA).Moreover,the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric ***: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control *** also found a significantly lower concentration of fibrinogen in women taking oral HRT *** control ***,no statistically significant changes in concentrations of TAT and D-dimer,or activity of protein C were ***: In this study,the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates *** significant modification of TAT or D-dimer occurred,and thus there may not be increased risk of thrombosis.

关键词： Menopause Coagulation hormone replacement therapy

Efficacy of Postoperative hormone replacement therapy on Prognosis of Patients with Serous Ovarian Carcinoma

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Chinese Medical Journal 2016年第11期129卷 1316-1321页

作者： Yong-Li Zhang Jin-Hong Chen Wen Lu Bi-Lan Li Qin-Yi Zhu Xiao-Ping Wan Department of Obstetrics and Gynecology Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai 201204 China

Background： Ovarian cancer is the most common cause of gynecological cancer-associated death. Iatrogenic menopause might adversely affect the quality of life and health outcomes in young female cancer survivors. We evaluated whether postoperative hormone replacement therapy （HRT） had a negative influence on the progression-free survival （PFS） of patients with papillary serous ovarian cancer （SOC）. Methods： We retrospectively reviewed the medical records of patients with papillary SOC, treated from January 1980 to December 2009, who suffered from menopause with or without HRT. Clinical characteristics of patients were compared between the two groups （HRT and non-HRT）. Blood samples were collected from all the participants to detect serum cancer antigen （CA） 125. Hazard ratios with 95% confidential intervals for each variable were calculated by univariable and multivariable conditional Logistic regression analyses. Results： Among 112 identified patients, 31 were HRT users and 81 were not. The two groups did not significantly differ in median age at diagnosis （t = 0.652, P = 0.513）, International Federation of Gynecology and Obstetrics （FIGO） stage （X2 = 0.565, P = 0.754）, differentiation （X2 = 1.728, P = 0.422）, resection status （X2 = 0.070, P = 0.791）, relapse （X2 = 0.109, P = 0.741）, chemotherapy course （t = -1.079, P - 0.282）, follow-up interval （t = 0.878, P = 0.382）, or PFS （t = 0.580, P = 0.562）. Median Kupperman score at the onset of HRT was 30.81 and 12.19 after the therapy （t： 3.302, P = 0.001）. According to the analysis, the strongest independent variables in predicting PFS were FIGO stage and disease that was not optimally debulked. Conclusions： Postoperative HRT is not a prognostic factor for PFS of patients with papillary SOC. However, multicenter studies are needed to verify and extend our findings.

关键词： hormone replacement therapy Prognosis Progression-free Survival Serous Papillary Ovarian Cancer

A comparison of two different dosages of conjugated equine estrogen in continuous combined hormone replacement therapy with progestin

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Chinese Medical Journal 2003年第4期116卷 584-587页

作者：邢淑敏吴宜勇刘建立徐茹兰张忠兰王莹 Department of Obstetrics and Gynecology China-Japan Friendship Hospital Department of Obstetrics and Gynecology Beijing Hospital Department of Obstetrics and Gynecology General Hospital of Chinese People’s Liberation Army

To investigate the effects of two different dosages of conjugated equine estrogen (CEE) on preventing bone loss and relieving the symptoms of menopausal syndrome in women at an early stage of menopause Methods A total of 236 postmenopausal women were randomly allocated to one of the following groups: Group A: 0 625 mg CEE+2 mg medroxyprogesterone acetate (MPA)+1 tab Caltrate-D per day; Group B: 0 3 mg CEE+2 mg MPA+1 tab Caltrate-D per day; Group C: 1 tab Caltrate-D per day as the control group The study was continued for 2 years The following parameters were monitored: ① L2-4 bone mineral density (BMD) (measured with dual energy X-ray absorptiometry (DEX)), ② menopausal syndr ome improvement (assessed by comparing Kupperman scores), ③ vaginal bleeding rate, and the thickness of the endometrium and breast in each group Results Overall, 213 cases (90%) completed the 1-year study and 176 cases (75%) completed the 2-year study The percentage changes in L2-4 BMD at the 12th and 24th month in Group A were +2 3% and +3 7%, respectively, with the posttreatment values being significantly higher than pretreatment values (P0 05) in Group B And that of Group C were -0 4% at 12t h month and -1 6% at 24th month (P>0 05) L2-4 BMD in both Group A and B w as significantly higher than that in Group C at 12th and 24th month (A vs C, P<0 001; B vs C, P<0 05) Kupperman Sco res were significantly reduced after 1, 3, 6 ,12 and 24 months in all 3 groups when compared with baseline (P<0 001) Scores in Group A and Group B were significantly lower than that in Group C (P<0 001) However, the vaginal bleeding rates in Group A were significantly higher than that in Group B or in Group C There was no atypical hyperplasia of endometrium in the 3 groups by the end of the study One p atient in Group A developed superficial thrombophlebitis by the end o

关键词： menopause hormone replacement therapy medroxyprogesterone acetate bone mineral density osteoporosis endometrium

Effect of hormone replacement therapy on heart rate variability in postmenopausal women

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Chinese Medical Journal 2000年第7期113卷 16-18页

作者：张海澄白文佩郭继鸿郑淑蓉赵京 Department of Cardiology People's Hospital Beijing Medical University Beijing 100044 China First Affiliated Hospital Beijing Medical University Beijing 100034 China

To assess the characteristics of autonomic control of heart rate in postmenopausal women before and after hormone replacement therapy (HRT) Methods Time domain and spectral domain heart rate variability (HRV) were performed in 58 postmenopausal women before and after HRT Results Compared with examinations at baseline, values of all HRV measurements in subjects given HRT were increased at the fourth month ( P 0 05) Results showed an inverse correlation between all measures of HRV and mean R R interval in the treatment group Conclusion HRT reduces sympathetic drive in postmenopausal symptomatic women HRV may be an index of imbalance of autonomic control in perimenopausal women

关键词： heart rate variability postmenopausal hormone replacement therapy

Effects of long-term,low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes

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Acta Pharmacologica Sinica 2007年第8期28卷 1129-1135页

作者： Yun YUE~1 Ling HU~2 Qin-jie TIAN~2 Jing-mei JIANG~ 1 Yi-long DONG~1 Zheng-yu JIN~2 Yu-hang CHENG~3 Xia HONG~2 Qin-sheng GE~2 Ping-ping ZUO~(1,4) ~1School of Basic Medicine,Peking Union Medical College and Institute of Basic Medical Seience,Chinese Academy of Medical Sciences,Beijing 100005,China ~2Peking Union Medical College Hospital,Beijing 100730,China ~3Beijing Anding Hospital,Beijing 100088,China School of Basic Medicine Peking Union Medical College and Institute of Basic Medical Science Chinese Academy of Medical Sciences Beijing China Peking Union Medical College Hospital Beijing China Beijing Anding Hospital Beijing China

Aim:To study the effects of long-term,low-dose sex hormone replacement therapy(HRT)on the volume and biochemical changes of the hippocampus in postmeno-pausal women carrying apolipoprotein E(apoE)gene ε3 or ε***:Eighty-three postmenopausal women who had used a low dose of HRT for over 4 yearswere selected as the HRT group,and 99 postmenopausal women with matchedage and education were enrolled as the control *** alleles were analyzedby *** resonance imaging was performed to determine the volume ofthe brain *** magnetic resonance spectroscopy was used todetect the biochemical changes in the anterior cingulate cortex and hippocampusin apoE ε4 and ε3 *** common cognitive tests were used to make anoverall evaluation of cognitive ***:Analysis with the apoE ε4carriers showed that the volume of the hippocampus of the control group weresignificantly lower than those of the HRT *** biochemical analysis showedthat there was an increase of N-acetylaspartate(NAA)/total creatine(tCr)and adecrease of myoinositol(mI)/tCr in the hippocampus of apoE ε4 carriers in theHRT group,compared with the control *** the apoE ε3 carriers,the leastsquares means(LSMEAN)of the HRT group was higher than that of the ***:This study showed that long-term,low dose HRT might bebeneficial for reducing the risk of AD development in vulnerable ***,HRT could increase the LSMEAN of apoE ε3 carriers.

关键词： hormone replacement therapy apoE Alzheimer’s disease magnetic resonance imaging