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histiocytic sarcoma of Thyroid in an old woman:a case report and review of literature

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Histiocytic sarcoma of Thyroid in an old woman:a case report...

Thrombocytopenia with multiple splenic lesions-histiocytic sarcoma of the spleen without splenomegaly: A case report

2019年浙江省病理学术大会

作者： Youliang Gao yongli Gan yingying Peng Fusang Ye Kuang Yang Jiahui Dul Department of Pathology Ningbo Clinical and Pathological Diagnosis Center Department of Surgical Ningbo City Medical Treatment Center Lihuili Hospital

We report a case of histiocytic sarcoma in a 71-year-old woman’s *** observation revealed an grey-yellow unencapsulated node in the left thyroid,measuring 30 mm in *** examination showed the left thyroid tumor cells were infiltration,Destructed thyroid follicular,no adhesion to each other,diffused distribution,middling and large tumor cells,round,orbicular-ovate,epithelium appearance,plentiful *** was round,orbicular-ovate,*** chromatin was vavuole appearance,basophilia mucleolus,caryocinesia and pathological mitotic *** muclei,increased pleomorphism with multimucleated tumor giant cell *** cytoplasmic with foamy *** was *** tumor cells were accompanied by various numbers of inflammatory *** was *** left thyroid tumor cells showed positivity for Ki-67(50%),CD163,CD68,*** negative for CDla,CK(pan),PTH,PAX-8,LCA,MPO,TG,TTF-1,Syn,CgA,*** vuscular CD31 is *** diagnosis of histiocytic sarcomain in the left thyroid were *** sarcoma was a rare lymphoid tissues malignancy in endocrine *** a detailed study of the reported cases,we summarized some clinicopathological differences between thyroid and lymphoid tissue.

关键词： histiocytic sarcoma sarcoma thyroid Introduction

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World Journal of Clinical Oncology 2020年第3期11卷 162-168页

作者： Kai Huang Alvaro Frometa Columbie Robert W Allan Subhasis Misra Department of General Surgery Brandon Regional HospitalHCA West Florida Division/USF ConsortiumBrandonFL 33511United States Department of Pathology and Laboratory Medicine Brandon Regional HospitalUniversity of South FloridaHCA West Florida DivisionBrandonFL 33511United States Chief Pathology and Laboratory Medicine Service North Florida and Southern Georgia VA SystemClinical Professor of PathologyUniversity of FloridaGainesvilleFL 32611United States

BACKGROUND histiocytic sarcoma(HS)of the spleen is reported to be a rare and lethal *** clinicopathological features of splenic HS have not been well *** objective of this paper is to describe the diagnosis and treatment of a case of this rare disease and provide a review of the *** SUMMARY In this article,we discuss the case of a 40-year-old Hispanic female who presented with progressive thrombocytopenia and multiple hypoechoic lesions in the spleen without *** emission tomography-computed tomography showed increased activity in cervical lymph nodes,as well as multiple bone and splenic lesions with positive *** bone marrow biopsies and fine-needle aspiration of the cervical lymph node were *** splenectomy was performed,and gross examination showed a 110.1 g spleen with multiple rubbery,nodular lesions within the subcapsular sinus and splenic *** microscopic findings showed multinodular histiocyte proliferation with atypia and multilobulated nuclei,which were positive for CD163,CD4,and CD68 by immunohistochemical *** final pathologic diagnosis was difficult and was found to be low-grade HS of the spleen,after consultations with two renowned hematopathology *** the patient’s five-month follow-up visit,her bone marrow metastasis had *** is waiting to be enrolled in a clinical *** Pathologic diagnosis of splenic HS can be ***-grade differentiation may be associated with a slow progressive disease.

关键词： histiocytic sarcoma Spleen Proliferation Thrombocytopenia Bone marrow metastasis Case report

Looking for a Rarity: histiocytic sarcoma

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Journal of Cancer Therapy 2016年第2期7卷 79-82页

作者： Joana de Castro Rocha Isabel Paiva Ana Rita Cruz Internal Medicine Centro Hospitalar do Porto Porto Portugal

histiocytic sarcoma is an extremely rare and very aggressive malignancy, with poor prognosis. The cases described in the literature are few and the treatment is not currently considered consensual. The clinical presentation is very variable. Its characterization is made based primarily on the histology. The authors present a case of an 82-year-old woman, with multiple adenopatic retroperitoneal and left iliac conglomerates, with left leg associated edema (extrinsic compression by conglomerates). After intensive study and approach ganglion biopsy, the histologic diagnosis revealed a histiocytic sarcoma.

关键词： histiocytic sarcoma Rarity Aggressive Malignancy Lymphadenopathy

Aggressive primary hepatic histiocytic sarcoma: case report and literature review

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Hepatoma Research 2016年第1期2卷 300-304页

作者： Guang Yang Jeremy Deisch Haixia Qin Craig Zuppan Anwar S.Raza Department of Pathology Loma Linda University Medical CenterLoma LindaCA 92354USA Department of Medicine Loma Linda University Medical CenterLoma LindaCA 92354USA

histiocytic sarcoma is an uncommon non-Langerhans histiocyte disorder of mature tissue *** authors presented an example of this rare tumor in a 14-year-old girl who presented with left upper quadrant pain,loss of appetite,and weight loss.A large 18 cm×10 cm heterogeneous solid and cystic enhancing mass was found in the left lobe of the *** on the histomorphology and positivity for histiocyte-specific markers in a needle biopsy,a diagnosis of histiocytic sarcoma was *** was initiated,but the tumor did not respond well,and she died about 7 weeks following initial diagnosis with multi-organ *** autopsy,the tumor showed extensive necrosis,with no evidence of metastatic *** conclusion,the diagnosis of histiocytic sarcoma is challenging,and requires a high index of suspicion,with an appropriate panel of confirmatory immunohistochemical *** of this rare tumor is important because of its poor response to chemotherapy and high mortality.

关键词： histiocytic sarcoma hepatic neoplasms liver

Malignant histiocytosis associated with mediastinal germ cell tumor:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7116-7123页

作者： Pei-Yi Yang Xiao-Li Ma Wen Zhao Li-Bing Fu Rui Zhang Qi Zeng Hong Qin Tong Yu Yan Su Department of Medical Oncology Pediatric Oncology CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Pathology Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China Hematology Center Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China Department of Thoracic Surgery Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Surgical Oncology Capital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Image Center Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijing 100045China

BACKGROUND Germ cell tumors(GCTs)account for 2%of human malignancies but are the most common malignant tumors among males aged *** 1983,an association between mediastinal GCT(MGCT)and hematologic malignancies has been *** SUMMARY We report a case in which malignant histiocytosis was associated with mediastinal *** clinical data of a male patient with MGCT admitted to Beijing Children's Hospital were collected *** patient was first diagnosed according to imaging and pathological features as having MGCT,and was treated with surgery and *** year after stopping chemotherapy,imaging showed metastases in the right supraclavicular,mediastinum,hilar region and retroperitoneal lymph node,right pleura,right lung,and right para-cardiac *** diagnosis of the liver nodular and hilar lymph nodes included systemic juvenile xanthogranuloma and Rosai-Dorfman lesions with malignant transformation(i.e.,morphological characteristics and immunophenotype of histiocytic sarcoma).Following diagnosis,the patient accepted chemotherapy with vindesine,cytarabine and *** emission tomography–computed tomography showed partial *** patient was followed-up for 10 mo after the diagnosis of malignant histiocytosis,and no sign of progression or relapse was *** Physicians should recognize the possibility of hematologic malignancies being associated with *** sites should be selected for pathological examination.

关键词： Germ cell tumor Mediastinal Malignant histiocytosis histiocytic sarcoma Hematologic malignancies Case report

Multiple disciplinary team management of rare primary splenic malignancy:Two case reports

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World Journal of Clinical Cases 2022年第29期10卷 10535-10542页

作者： Hao Luo Tao Wang Le Xiao Chao Wang Hai Yi Department of General Surgery Center General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina Department of Pathology General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina Department of Hematology General Hospital of Western TheaterChengdu 610083Sichuan ProvinceChina

BACKGROUND Malignant splenic tumors are rare but fatal,presenting a challenge in diagnosis and management involving hematology,oncology,and general *** contrast,diagnosing and treating other common malignant tumors(such as lung and gastrointestinal cancer)offers multiple strategies for chemotherapy,radiotherapy,targeted therapy,and immunotherapy with the prospect of a *** various specialists involved in clinical multiple disciplinary team(MDT)discussion,personal bias can be *** can also ignite important discussion which can benefit not only one patient but many *** SUMMARY Here,we report on the MDT diagnosis and management of the malignant splenic tumors littoral cell angiosarcoma and histiocytic *** only two cases of rare primary splenic malignancy are presented,MDT is a novel means of rare disease *** To benefit patients,imaging analysis,safe operation,precise pathology examination,and individualized therapeutic treatment strategies are *** involvement of various specialists in a clinical MDT discussion minimizes personal bias and can create important ideas to benefit all patients.

关键词： Multiple disciplinary team Splenic malignancy Littoral cell angiosarcoma histiocytic sarcoma Case report