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Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells

World Journal of Gastroenterology 2014年第1期20卷 175-182页

作者： Hye Jin Ku Hye Young Kim Hyeong Hoe Kim Hee Ju Park Jae Hun Cheong Department of Pediatrics College of MedicinePusan National UniversityBusan 601-721South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 609-735South Korea Department of Experimental Medicine College of MedicinePusan National UniversityBusan 601-721South Korea

AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon coope... 详细信息

关键词： Histamine histidine decarboxylase Bile acid Farnesoid X receptor

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histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours

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World Journal of Gastroenterology 2015年第47期21卷 13240-13249页

作者： Apostolos V Tsolakis Lars Grimelius Göran Granerus Mats Stridsberg Sture E Falkmer Eva T Janson Section of Endocrine Oncology Department of Medical SciencesUppsala University Section of Genetics and Pathology Department of ImmunologyUppsala University Department of Medical and Health Sciences Linköping University Section of Biochemical Endocrinology Department of Medical SciencesUppsala University Department of Pathology Ryhov County Hospital

AIM: To study histidine decarboxylase(HDC) expression in normal and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite. METHODS: Control tissues from fundus(n = 3) and corpus(n = 3) mucosa of six patients undergoing operations for gastric adenocarcinoma, biopsy and/or gastric surgical specimens from 64 patients with primary gastric neuroendocrine tumours(GNETs), as well as metastases from 22 of these patients, were investigated using conventional immunohistochemistry and double immunofluorescence with commercial antibodies vs vesicular monoamine transporter 2(VMAT-2), HDC and ghrelin. The urinary excretion of the main histamine metabolite methylimidazoleacetic acid(U-Me Im AA) was determined using highperformance liquid chromatography in 27 of the 64 ***: In the gastric mucosa of the control tissues, co-localization studies identified neuroendocrine cells that showed immunoreactivity only to VMAT-2 and others with reactivity only to HDC. A third cellpopulation co-expressed both antigens. There was no co-expression of HDC and ghrelin. Similar results were obtained in the foci of neuroendocrine cell hyperplasia associated with chronic atrophic gastritis type A and also in the tumours. The relative incidence of the three aforementioned markers varied in the tumours that were examined using conventional immunohistochemistry. All of these GNETs revealed both VMAT-2 and HDC immunoreactivity, and their metastases showed an immunohistochemical pattern and frequency similar to that of their primary tumours. In four patients, increased U-Me Im AA excretion was detected, but only two of the patients exhibited related endocrine symptoms. CONCLUSION: Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Coexpression of VMAT-2 and HDC might be required for increased histamine production in patients with GNETs.

关键词： Enterochromaffin-like cells High performance liquid chromatography Gastric neuroendocrine tumours histidine decarboxylase Immunohistochemistry Urinary excretion of the main histamine metabolite methylimidazoleacetic acid Vesicular monoamine transporter 2

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Ghrelin and gastric acid secretion

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World Journal of Gastroenterology 2008年第41期14卷 6334-6338页

作者： Koji Yakabi Junichi Kawashima Shingo Kato Department of Gastroenteology and Hepatology Saitama Medical Center Saitama Medical University Kawagoe-city

Ghrelin, a novel growth hormone-releasing peptide, was originally isolated from rat and human stomach. Ghrelin has been known to increase the secretion of growth hormone (GH), food intake, and body weight gain when administered peripherally or centrally. Ghrelin is also known to stimulate the gastric motility and the secretion of gastric acid. In the previous studies, the action of ghrelin on acid secretion was shown to be as strong as that of histamine and gastrin in in-vivo experiment. In the studies, the mechanism for the action of ghrelin was also investigated. It was shown that vagotomy completely inhibited the action of ghrelin on the secretion of gastric acid suggesting that vagal nerve is involved in the mechanism for the action of ghrelin on acid secretion. As famotidine did not inhibit ghrelin-in-duced acid secretion in the study by Masuda et al, they concluded that histamine was not involved in the action of ghrelin on acid secretion. However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion. Furthermore synergistic action of gastrin and ghrelin on gastric acid secretion was shown. Although gastrin has important roles in postprandial secretion of gastric acid, ghrelin may be related to acid secretion during fasting period or at night. However, further studies are needed to elucidate the physiological role of ghrelin in acid secretion.

关键词： Ghrelin Acid secretion Vagal nerve Vogotomy Histamine histidine decarboxylase

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