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Evaluation of the Antidiabetic Activity and Toxicological Properties of hippocratea velutina (Afzel.)

Clinical Complementary Medicine and Pharmacology 2023年第2期3卷 50-56页

作者： Farouk A.Oladoja Emmanuel SIrokosu Marcus D.Ayoola Oyinloye O.Elijah Murtala A.Akanji Ogunleye T.Beatrice Odewo A.Samuel Department of Pharmacology and Toxicology Faculty of PharmacyOlabisi Onabanjo UniversityAgo-Iwoye 121102Ogun-State.Nigeria Department of Pharmacology and Therapeutics Faculty of Basic Medical ScienceOlabisi Onabanjo University.Ago-Iwoye 121102Ogun-State.Nigeria Department of Pharmacognosy Faculty of PharmacyObafemi Awolowo University Ile-Ife 220282Osun-State.Nigeria Forest Research Institute of Nigeria Ibadan 200221Oyo-State.Nigeria

Background:hippocratea velutina(HV)is a novel plant folklorically used for lowering blood glucose,hence a potential source of new antidiabetic ***:The study evaluated the anti-diabetic potentials of the methanol extract of hippocratea velutina leaf and its toxicity profile in mice and ***:Acute and subacute toxicity tests of the plant extract were carried out by using a modified OECD *** antidiabetic activity in streptozotocin-induced diabetic rats at 50,150,and 300 mg/kg for 28 days was assayed,while glibenclamide(5 mg/kg)and distilled water were the positive and negative controls,*** examination of vital organs was also carried ***:Preliminary phytochemical screening of the leaf extract showed the presence of tannins,flavonoids,saponins,alkaloids,terpenoids,deoxy-sugars,and anthraquinones in *** extract had LD 50 greater than 2000 mg/kg in *** had no toxic effects on the haematological and biochemical components from blood samples collected but caused significant blood glucose level reduction in normal rats at 150 and 300 mg/*** streptozotocin-induced diabetic rats,the extract elicited a non-dose-dependent antidiabetic effect on day seven at all the tested doses,significantly higher than glibenclamide(10 mg/kg).However,on days 14,21,and 28,the extract activity at all the tested doses and glibenclamide were *** extract did not affect the liver,brain,kidney,and pancreas histology at 200 mg/kg but caused slight and severe effects on these organs at 400 and 800 mg/kg,***:The study concluded that hippocratea velutina possessed antihyperglycaemic activity and was non-toxic at low doses but could have deleterious effects to the liver and kidney at high concentrations.

关键词： hippocratea velutina Diabetes mellitus Haematological and biochemical parameters

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