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Effect of gestation dietary methionine-to-lysine ratio on methionine metabolism and antioxidant ability of high-prolific sows

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Animal Nutrition 2021年第3期7卷 849-858页

作者： Mao Xia Jie Peng Chenbin Cui Qiongyao Gu Linjie Zhou Chao Wang Haiqing Sun Jian Peng Hongkui Wei Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Innovation Institute of Healthy Fariming College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhouGuangdong 510225China Department of Chemistry College of ScienceHuazhong Agricultural UniversityWuhan 430070China YangXiang Joint Stock Company Guigang 537000China

The uptake and metabolism of methionine(Met)are critical for epigenetic regulation,redox homeostasis,and embryo *** previous study showed that appropriate supplementation of dietary Met promoted the birth weight and placental angiogenesis of high-prolific *** further explore the metabolic effect of Met on pregnant sows,we have evaluated the influence of dietary Met level on Met metabolism,and the relationship between metabolites of Met and reproductive performance,antioxi-dant ability,and placental angiogenesis throughout the gestation of high-prolific *** sows(the 3rd parity,Large White)were randomly divided into 5 groups that were fed diets with standardized ileal digestible(SID)methionine-to-lysine(Met:Lys)ratios of 0.27(control),0.32,0.37,0.42,and 0.47 from the mating day(gestational d 0,G0d)until the farrowing ***-MS/MS analysis was used to simulta-neously evaluate the metabolites related to Met,e.g.S-adenosylmethionine(SAM),S-adenosylhomo-cysteine(SAH),homocysteine(Hcy),cysteine(Cys),and glutathione(GSH).The concentration of SAM and SAH in plasma had significant fluctuations,especially in late *** dietary Met sup-plementation significantly improved the plasma SAM and methylation potential(SAM-to-SAH ratio)at d 114 of pregnancy(G114d).Moreover,a positive association of the plasma SAM concentration at G114d was observed with the litter weight of born alive(P<0.05;R2=0.58).Furthermore,Hcy concentration in plasma was at the lowest level for 0.37 ratio group at ***,it significantly increased during late ***,there were negative correlations between plasma Hcy concentration at G114d(P<0.05)and the placental vascular density in the fold and stroma(P<0.05).Compared with the control group,the expression of vascular endothelial growth factor-A(VEGF-A)in the placenta tissue of 0.37 ratio group increased significantly(P<0.05).Collectively,these findings indicate that dietary Met:Lys ratio(0.37 to 0.57)in

关键词： Antioxidant ability Dietary methionine high-prolific sows Metabolism Reproductive performance Placental angiogenesis

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