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high-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma

World Journal of Gastroenterology 2015年第11期21卷 3256-3265页

作者： Yun-Fei Xu Fu-Jun Ge Bo Han Xiao-Qing Yang Hong Su An-Cheng Zhao Ming-Hong Zhao Yu-Bao Yang Jie Yang Department of Hepatobilliary Surgery Shandong University Qilu Hospital Department of General Surgery Affiliated Hospital of Shandong Medical School Department of Pathology Shandong University Medical School Department of Clinical Laboratory Yishui Central Hospital Department of Pediatrics Shandong University Qilu Hospital

AIM:To evaluate the prognostic value of high-mobility group box 1(HMGB1) expression in intrahepatic cholangiocarcinoma(IHCC) and the possible underlying ***:Tissue microarray was constructed from 65 IHCC *** was performed to validate expression of HMGB1 and Vascular endothelial growth factor C(VEGF-C).Realtime PCR and Western blot analyses were used to study transcript and protein *** interaction between HMGB1 and VEGF-C was evaluated by si RNA,real-time PCR,and enzyme-linked immuno *** correlation between HMGB1 expression and other clinicopathologic parameters was analyzed byχ2 test,and the univariate as well as multivariate analyses were accomplished by Kaplan-Meier method and Coxregression model,***:Overall,overexpression of HMGB1 was found in 38/65(58.8%)IHCCs,whereas VEGF-C overexpression was present in 30/65(46.2%)*** of HMGB1 was significantly correlated with lymphatic microvessel density(P=0.031,r=0.268)and VEGF-C expression(P=0.041,r=0.254).With univariate analysis,both HMGB1(P=0.001)and VEGF-C(P=0.004)were identified to be significantly associated with overall survival *** indicated that HMGB1 could be served as an unfavorable independent prognostic factor in IHCCs(P=0.005).si RNA knockdown of HMGB1 inhibited transforming growth factor-β-induced epithelialmesenchymal transition(EMT)by elevating E-Cadherin expression and reducing expression of N-Cadherin,Vimentin and Snail in RBE *** in vitro study revealed that HMGB1 silencing significantly decreased the level of VEGF-C,whereas the recombinant HMGB1increased the VEGF-C level in RBE cells(both P<0.05),which suggested that HMGB1 could promote lymphatic microvessel density,and subsequently lymphatic invasion,via promoting VEGF-C ***:Our results define an important role of HMGB1 in the progression of cholangiocarcinoma,and HMGB1 may serve as a prognostic marker for IHCC pati

关键词： Epithelial-mesenchymal transition high-mobility gr

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Multiple Vandermonde Decomposition Based Channel Estimation for Mm Wave MIMO high-mobility Communication in 5G and Beyond

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China Communications 2023年第4期20卷 12-25页

作者： Zhao Yi Xiaojun Jing School of Electronics and Information Hunan First Normal UniversityChangsha 410205China Key Laboratory of Trustworthy Distributed Computing and Service Ministry of EducationBeijing University of Posts and TelecommunicationsBeijing 100876China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Millimeter wave(mmWave)massive massive multiple input multiple output(MIMO)technique has been regarded as the viable solution for vehicular communications in 5G and *** achieve the substantial increase in date rates,it is important to take an effective channel state information(CSI).However,existing channel estimation strategies are unavailable since the users *** solve above issues,in this paper,inspired by a specific antenna structure,we propose a novel approach for fast time-varying channel ***,by considering the vehicle scenario with high-mobility,a corresponding mathematical model is firstly ***,based on the special structural of the sparse array,the switch network is used to replace the convention phase shifter of mmWave hybrid system,which can effectively reduce the number of radio-frequency(RF)chains and ***,by solving the semidefinite programming(SDP)duality problem,the Doppler frequency and path parameters are effectively *** results are shown that the computational complexity and estimation accuracy of the proposed algorithm is superior than that of the traditional schemes.

关键词： MIMO mmWave channel estimation high-mobility time-variant

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Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok Choi Won-Seok Jung Su-Young Jung Jung-Hee Cho Mee-Ok Choi Ho-Joon Song Sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis high-mobility group box protein-1

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Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 898-903页

作者： Jia-Qian Jiang Cui Li Cong-Xian Cui Yu-Na Ma Gui-Qiu Zhao Xu-Dong Peng Qiang Xu Qian Wang Guo-Qiang Zhu Chen-Yu Li Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To investigate the inflammatory amplification effect of high-mobility group box 1(HMGB1) in Aspergillus fumigatus(A. fumigatus) keratitis and the relationship between lectin-like oxidized low-density lipoprotein receptor 1(LOX-1) and HMGB1 in keratitis immune ***: Phosphate buffer saline(PBS), and Boxb were injected into BALB/c mice subconjunctivally before the corneas were infected with A. fumigatus. RAW264.7 macrophages and neutrophils were pretreated with PBS and Boxb to determine the HMGB1 inflammatory amplification effects. Abdominal cavity extracted macrophages were pretreated with Boxb and Poly(I)(a LOX-1 inhibitor) before A. fumigatus hyphae stimulation to prove the the relationship between the two molecules. LOX-1, interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), macrophage inflammatory protein-2(MIP-2) and IL-10 were assessed by polymerase chain reaction and Western ***: Pretreatment with Boxb exacerbated corneal inflammation. In macrophages and neutrophils, A. fumigatus induced LOX-1, IL-1β, TNF-α and MIP-2 expression in Boxb group was higher than those in PBS group. Poly(I) treatments before infection alleviated the proinflammatory effects of Boxb in abdominal cavity extracted macrophages. Pretreatment with Boxb did not influence Dectin-1 mRNA levels in macrophages and ***: In fungal keratitis, HMGB1 is a proinflammatory factor in the first line of immune response. HMGB1 mainly stimulates neutrophils and macrophages to produce inflammatory cytokines and chemokines during the immune response. LOX-1 participates in HMGB1 induced inflammatory exacerbation in A. fumigatus keratitis.

关键词： Aspergillus fumigatus keratitis high-mobility group box 1 LOX-1

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Low-power high-mobility organic single-crystal field-effect transistor

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Science China Materials 2022年第10期65卷 2779-2785页

作者： Beibei Fu Lingjie Sun Lei Liu Deyang Ji Xiaotao Zhang Fangxu Yang Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Institute of Molecular Aggregation Science of Tianjin University Tianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China

Evolving flexible electronics requires the development of high-mobility and low-power organic field-effect transistors(OFETs)that are crucial for emerging displays,sensors,and label *** diverse materials,polymer gate dielectrics and two-dimensional(2D)organic crystals have intrinsic flexibility and natural compatibility with each other for OFETs with high performance;however,their combination lacks non-impurity and non-damage construction *** this study,we developed a desirable OFET system using damage-free transfer of 2D organic single crystal,dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene on a unique polymer dielectric layer,poly(amic acid)(PAA).Benefiting from the unique PAA surface nanostructure and the long-range ordered characteristics of the 2D organic single crystal,the resulting OFETs show remarkable performance with high mobility and low operating voltage of 18.7 cm^(2) V^(−1) s^(−1) and−3 V,*** result indicates that combining polymer gate dielectric with 2D organic single crystal using a high-quality method can produce flexible electronic devices with high performance.

关键词： organic field-effect transistor polymer dielectrics 2D organic crystals high-mobility low power consumption

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高拉伸高迁移率半导体纳米纤维共混薄膜应用于完全可拉伸有机晶体管

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Science China Materials 2023年第5期66卷 1891-1898页

作者：邬福明刘忆旋张鋆李湘湘杨辉胡文平 Tianjin Key Laboratory of Molecular Optoelectronic Science Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China

可拉伸有机场效应晶体管(OFETs)是有机集成电路和可穿戴生物传感器的基本组成部分.可拉伸有机半导体是实现高迁移率可拉伸OFETs的核心材料.目前实现高迁移率高拉伸聚合物半导体仍面临挑战.在此,我们通过混合聚合物半导体和弹性体,制备... 详细信息

可拉伸有机场效应晶体管(OFETs)是有机集成电路和可穿戴生物传感器的基本组成部分.可拉伸有机半导体是实现高迁移率可拉伸OFETs的核心材料.目前实现高迁移率高拉伸聚合物半导体仍面临挑战.在此,我们通过混合聚合物半导体和弹性体,制备了高迁移率可拉伸的半导体共混薄膜.通过纳米限域效应,聚合物形成独特的纳米纤维.半导体薄膜具有低结晶度和高聚集度,因此该纤维共混薄膜具有高迁移率和高拉伸性.我们制备的完全可拉伸的有机晶体管在0%和100%应变下空穴迁移率分别为2.74和2.53 m^(2)V^(-1)s^(-1).即使在150%应变下,可拉伸晶体管的迁移率也高达1.57 cm^(2)V^(-1)s^(-1).可拉伸晶体管在30%应变下的1000个拉伸/释放周期中表现出了高的机械鲁棒性.

关键词： high-mobility stretchable semiconductors nanofibers organic transistors

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Ferroelectricity in hBN intercalated double-layer graphene

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Frontiers of physics 2022年第4期17卷 59-65页

作者： Yibo Wang Siqi Jiang Jingkuan Xiao Xiaofan Cai Di Zhang Ping Wang Guodong Ma Yaqing Han Jiabei Huang Kenji Watanabe Takashi Taniguchi Yanfeng Guo Lei Wang Alexander S.Mayorov Geliang Yu National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China National Institute for Materials Science 1-1 NamikiTsukuba 305-0044Japan Collaborative Innovation Centre of Advanced Microsctructures Nanjing UniversityNanjing 210093China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China

Van der Waals(vdW)assembly of two-dimensional materials has long been recognized as a powerful tool for creating unique systems with properties that cannot be found in natural compounds[Nature 499,419(2013)].However,among the variety of vdW heterostructures and their various properties,only a few have revealed metallic and ferroelectric behaviour signatures[***.5,eaax5080(2019);Nature 560,336(2018)].Here we show ferroelectric semimetal made of double-gated double-layer graphene separated by an atomically thin crystal of hexagonal boron *** structure demonstrates high room temperature mobility of the order of 10 m2·V^(−1)·s^(−1) and exhibits ambipolar switching in response to the external electric *** observed hysteresis is reversible and persists above room *** fabrication method expands the family of ferroelectric vdW compounds and offers a promising route for developing novel phase-changing devices.A possible microscopic model of ferroelectricity is discussed.

关键词： double-layer graphene ferroelectric metal intercalation dry transfer high-mobility

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TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

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World Journal of Gastroenterology 2015年第27期21卷 8314-8325页

作者： Jie Wang Gui-Zhen He Yu-Kang Wang Qian-Kun Zhu Wei Chen Tai Guo Department of Parenteral and Enteral Nutrition Peking Union Medical College Hospital Centre for Translational Medicine Chinese Academy of Medical Sciences and Peking Union Medical College National Institutes for Food and Drug Control

AIM: To characterize high-mobility group protein 1-toll-like receptor 4(HMGB1-TLR4) and downstream signaling pathways in intestinal ischemia/reperfusion(I/R) ***: Forty specific-pathogen-free male C57BL/6 mice were randomly divided into five groups(n = 8 per group): sham, control, anti-HMGB1, anti-myeloid differentiation gene 88(My D88), and anti-translocatingchain-associating membrane protein(TRIF) antibody groups. Vehicle with the control Ig G antibody, antiHMGB1, anti-My D88, or anti-TRIF antibodies(all 1 mg/kg, 0.025%) were injected via the caudal vein 30 min prior to ischemia. After anesthetization, the abdominal wall was opened and the superior mesenteric artery was exposed, followed by 60 min mesenteric ischemia and then 60 min reperfusion. For the sham group, the abdominal wall was opened for 120 min without I/R. Levels of serum nuclear factor(NF)-κB p65, interleukin(IL)-6, and tumor necrosis factor(TNF)-α were measured, along with myeloperoxidase activity in the lung and liver. Inaddition,morphologic changes that occurred in the lung and intestinal tissues were evaluated. Levels of m RNA transcripts encoding HMGB1 and NF-κB were measured by real-time quantitative PCR, and levels of HMGB1 and NF-κB protein were measured by Western blot. Results were analyzed using one-way analysis of ***: Blocking HMGB 1, MyD 8 8, and TRIF expression by injecting anti-HMGB1, anti-My D88, or anti-TRIF antibodies prior to ischemia reduced the levels of inflammatory cytokines in serum; NF-κB p65: 104.64 ± 11.89, 228.53 ± 24.85, 145.00 ± 33.63, 191.12 ± 13.22, and 183.73 ± 10.81(P < 0.05); IL-6: 50.02 ± 6.33, 104.91 ± 31.18, 62.28 ± 6.73, 85.90 ± 17.37, and 78.14 ± 7.38(P < 0.05); TNF-α, 43.79 ± 4.18, 70.81 ± 6.97, 52.76 ± 5.71, 63.19 ± 5.47, and 59.70 ± 4.63(P < 0.05) for the sham, control, anti-HMGB1, anti-My D88, and anti-TRIF groups, respectively(all in pg/m L).Antibodies also alleviated tissue injury in the lung and small intestine compared with the

关键词： C57BL/6 mouse high-mobility group protein1 Intestinal ischemia-reperfusion injury Myeloid differentiationgene 88 Nuclear factor-κB translocatingchain-associating membrane protein

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TEM and STEM Observations of a Flat Continuous Silicon-Germanium Thin Film Epitaxially Grown on Porous Silicon

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Journal of Materials Science and Chemical Engineering 2017年第1期5卷 26-34页

作者： Junji Yamanaka Noritaka Usami Sevak Amtablian Alain Fave Mustapha Lemiti Chiaya Yamamoto Kiyokazu Nakagawa Center for Crystal Science and Technology University of Yamanashi Kofu Japan Graduate School of Engineering Nagoya University Nagoya Japan Institut des Nanotechnologies de Lyon site INSA-Lyon Villeurbanne France Center for Creative Technology University of Yamanashi Kofu Japan Center for Instrumental Analysis University of Yamanashi Kofu Japan

Strain-relaxed SiGe is an attractive material for use as a substrate of strained Si, in which carrier mobility is higher than that of bulk Si. The concept of this study is the use of porous Si as a sponge like substrate so that a SiGe lattice can relax without introducing dislocations. We produced porous Si specimens by electrochemical anodization and annealed them under a H2 atmosphere. Then, SiGe thin films were grown by gas-source molecular beam epitaxy. We observed the microstructure of the specimens using transmission electron microscopy. The result showed that we succeeded in producing a single-crys- tal continuous Si0.73Ge0.27 film with a 10% relaxation ratio and a low dislocation density on porous Si.

关键词： Porous Silicon Silicon Germanium Strain Relaxation Strained Silicon Nanostructure high-mobility Semiconductors Transmission Electron Microscopy

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The Concept Study of Recombinant Human Soluble Thrombomodulin in Patients with Acute Respiratory Distress Syndrome

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International Journal of Clinical Medicine 2013年第11期4卷 488-495页

作者： Kenji Tsushima Toshiki Yokoyama Tomonobu Koizumi Keishi Kubo Koichiro Tatsumi Department of Pulmonary Medicine Shinonoi General Hospital Nagano Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan First Department of Internal Medicine Shinshu University School of Medicine Nagano Japan

Background: Recombinant human soluble thrombomodulin (rhTM) was approved for the treatment of disseminated intravascular coagulation in Japan, and rhTM has anti-inflammatory effects. Disordered coagulation is a part of the acute respiratory distress syndrome (ARDS) pathophysiology and thus we hypothesize that anticoagulant therapy may help. This preliminary study was to observe the safety of rhTM administration and the improvement on biomarker levels after the therapy for ARDS-patients. Objectives: Case series of ARDS-patients. Methods: Seventeen ARDS-patients that required ventilatory management were treated with rhTM and clinical and laboratory data were collected including platelets, thrombin-antithrombin complex (TAT), fibrinogen degradation products, oxygen saturation/the fraction of inspired oxygen (SpO2/FIO2), and high-mobility group-1 (HMG-1). The administration of rhTM was started during 6 days at a bolus dose of 0.06 mg/kg/day immediately after the diagnosis of ARDS. Results: Eleven of the 17 ARDS-patients were alive at 28 days after the beginning of the administration of rhTM. The serial pattern of the SpO2/FIO2 showed remarkable differences between the survivors and nonsurvivors from day 5 to day 7. The TAT in the survivors significantly decreased after treatment, and there were significantly lower levels in the TAT on day 7 in comparison to that of the nonsurvivors. The serial changes of HMG-1 showed increased levels in the nonsurvivors until day 5 after the administration of rhTM. Conclusions: Additional rhTM administration can safely improve the parameters in survival ARDS-patients, as demonstrated by significant improvements in the SpO2/FIO2, HMG-1 and TAT.

关键词： Acute Respiratory Distress Syndrome Recombinant Human Soluble Thrombomodulin Thrombin-Antithrombin Complex SpO2/FIO2 high-mobility Group-1

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