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high-intensity focused ultrasound treatment for patients with unresectable pancreatic cancer

Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 655-660页

作者： Peng-Zhou Li, Shai-Hong Zhu, Wei He, Li-Yong Zhu, Sheng-Ping Liu, Yan Liu, Guo-Hui Wang, Fei Ye Department of General Surgery ,Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China Department of General Surgery Third Xiangya Hospital Central South University Changsha 410013 China Department of Radiology Third Xiangya Hospital Central South University Changsha 410013 China

BACKGROUND: high-intensity focused ultrasound (HIFU) is a non-invasive method of solid tissue ablation therapy. However, only a few studies have reported the effect of HIFU for unresectable pancreatic cancer. This study aimed to evaluate the clinical benefits, survival time and complications associated with the use of HIFU ablation in patients with unresectable pancreatic cancer. METHODS: Twenty-five patients with unresectable pancreatic cancer were enrolled in our study. All patients received HIFU therapy for tumors at least once. The therapeutic effects of HIFU was evaluated in terms of Karnofsky performance status (KPS) scores, pain relief, serum CA19-9, and imaging by B-US and CT before and after the therapy. We also recorded median overall survival time and complications caused by the treatment. RESULTS: In the 25 patients, KPS scores were above 60, and increased KPS was observed in 23 patients after treatment. Pain relief occurred in 23 patients. Serum CA19-9 levels were significantly reduced one month after HIFU treatment and became negative in 5 patients. B-US revealed enhanced tumor echogenicity in 13 patients and decreased tumor blood supply in 9. Tumor necrosis was confirmed by CT in 8 patients one month after HIFU treatment. The median overall survival time was 10 months, and the 1-year survival rate was 42%. No severe complications were observed after HIFU treatment. CONCLUSION: HIFU can effectively relieve pain, increase KPS, decrease tumor growth and prolong the survival time of patients with unresectable pancreatic cancer.

关键词： pancreatic cancer high-intensity focused ultrasound therapy

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high-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 542-544页

作者： Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo Department of Surgery The University of Hong Kong Department of Pathology The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later.

关键词： high-intensity focused ultrasound hepatocellular carcinoma liver cirrhosis liver transplantation bridging therapy

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Numerical simulations of partial elements excitation for hemispherical high-intensity focused ultrasound phased transducer

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Chinese Physics B 2021年第7期30卷 668-677页

作者： Yanqiu Zhang Hao Zhang Tianyu Sun Ting Pan Peiguo Wang Xiqi Jian School of Biomedical Engineering&Technology Tianjin Medical UniversityTianjin 300070China College of Precision Instruments and Optoelectronics Engineering Tianjin UniversityTianjin 300072China Department of Radiotherapy Cancer Institute and Hospital of Tianjin Medical UniversityTianjin 300070China

The hemispherical phased transducer maximizes the coverage of the skull and the ultrasonic energy per unit area of the skull is minimized,thereby reducing the risk of skull burns,but the transducer has a small focal area adjustment range,increasing the focal length of treatment is an urgent question for this type of *** this paper,a three-dimensional high-intensity focused ultrasound(HIFU)transcranial propagation model is established based on the human head *** finite difference time domain(FDTD)is combined with the Westervelt acoustic wave nonlinear propagation equation and Penne's biological heat conduction equation for numerical simulation of the sound pressure field and temperature *** a treatable focal area in a small-opening hemispherical transducer with a small amount of numerical simulation calculation focusing at a set position to determine the minimum partial excitation area ratio of *** then,applying these preliminary results to a large-opening diameter hemispherical transducer and the temperature field formed by it or full excitation is *** results show that the focus area with the excitation area ratio of less than 22%moves forward to the transducer side when the excitation sound is *** the excitation area ratio is greater than or equal to 23%,it focuses at the set *** the case of partial incentives,using 23%of the partial array,the adjustable range of the treatable focal area formed in the three-dimensional space is larger than that of the full excitation.

关键词： high-intensity focused ultrasound partial elements excitation simulation phased transducer

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Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

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World Journal of Gastroenterology 2010年第28期16卷 3584-3591页

作者： Ying Zhang Jian Deng Jun Feng Feng Wu Institute of Ultrasonic Engineering in Medicine Chongqing Medical University Chongqing 400016 China

AIM:To investigate whether tumor debris created by high-intensity focused ultrasound(HIFU)could trigger antitumor immunity in a mouse hepatocellular carcinoma model. METHODS:Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor *** mice underwent HIFU ablation,and the remaining 10 mice received a sham-HIFU procedure with no ultrasound *** normal mice were randomly divided into HIFU vaccine,tumor vaccine and control *** mice were immunized with HIFU-generated vaccine,tumor-generated vaccine,and saline,*** addition,20 mice bearing H22 tumors were successfully treated with HIFU ablation. The protective immunity of the vaccinated mice was investigated before and after a subsequent H22 tumor *** the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay,the cytotoxicity of splenic lymphocytes co-cultured with H22 cells wasdetermined in vitro before the tumor challenge,and tumor volume and survival were measured in vivo after the challenge in each *** mechanism was also explored by loading the vaccines with bone marrowderived dendritic cells(DCs). RESULTS:Compared to the control,HIFU therapy, tumor-generated and HIFU-generated vaccines significantly increased cytolytic activity against H22 cells in the splenocytes of the vaccinated mice(P<0.001). The tumor volume was significantly smaller in the HIFU vaccine group than in the tumor vaccine group(P <0.05)and control group(P<0.01).However,there was no tumor growth after H22 rechallenge in the HIFU therapy ***-eight-day survival rate was 100%in mice in the HIFU therapy group,30%in both the HIFU vaccine and tumor vaccine groups,and 20% in the control group,indicating that the HIFU-treated mice displayed significantly longer survival than the vaccinated mice in the remaining three groups(P< 0.001).After bone marrow-derived DCs were incubated with HIFU-generated and tumor-generated vaccines, the number of matur

关键词： Hepatocellular carcinoma high-intensity focused ultrasound Immune response Immunogenicity Immunotherapy Thermal ablation Tumor vaccine

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The feasibility and safety of high-intensity focused ultrasound combined with low-dose external beam radiotherapy as supplemental therapy for advanced prostate cancer following hormonal therapy

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Asian Journal of Andrology 2011年第3期13卷 499-504,515页

作者： Rui-Yi Wu Guo-Min Wang Lei Xu Bo-Heng Zhang Ye-Qing Xu Zhao-Chong Zeng Bing Chen Department of Urology Zhongshan Hospital Fudan University Shanghai 200032 China Evidence-Based Medicine Center Fudan University Shanghai 200032 China Department of Radiotherapy Zhongshan Hospital Fudan University Shanghai 200032 China

The aim of this study was to investigate the feasibility and safety of high-intensity focused ultrasound （HIFU） combined with （＋） low-dose external beam radiotherapy （LRT） as supplemental therapy for advanced prostate cancer （PCa） following hormonal therapy （HT）. Our definition of HIFU＋LRT refers to treating primary tumour lesions with HIFU in place of reduced field boost irradiation to the prostate, while retaining four-field box irradiation to the pelvis in conventional-dose external beam radiotherapy （CRT）. We performed a prospective, controlled and non-randomized study on 120 patients with advanced PCa after HT who received HIFU, CRT, HIFU＋LRT and HT alone, respectively. CT/MR imaging showed the primary tumours and pelvic lymph node metastases visibly shrank or even disappeared after HIFU ＋LRT treatment. There were significant differences among four groups with regard to overall survival （OS） and disease-specific survival （DSS） curves （P=0.018 and 0.015）. Further comparison between each pair of groups suggested that the long-term DSS of the H IFU ＋ LRT group was higher than those of the other three groups, but there was no significant difference between the HIFU＋LRT group and the CRT group. Multivariable Cox＇s proportional hazard model showed that both HIFU＋LRT and CRT were independently associated with DSS （P=0.001 and 0.035） and had protective effects with regard to the risk of death. Compared with CRT, HIFU ＋LRT significantly decreased incidences of radiation-related late gastrointestinal （GI） and genitourinary （GU） toxicity grade ≥ II. In conclusion, long-term survival of patients with advanced PCa benefited from strengthening local control of primary tumour and reRional lymph node metastases after HT. As an alternative to CRT, HIFU＋LRT showed Rood efficacy and better safety.

关键词： complication high-intensity focused ultrasound hormonal therapy low-dose external beam radiotherapy prostate cancer survival rate

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Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9570-9577页

作者： Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi Department of Gastroenterology and Hepatology Tokyo Medical University

AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or *** consent was *** study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at *** were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,*** after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care *** events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in ***,no severe adverse events occurred in this ***:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC.

关键词： high-intensity focused ultrasound Pancreatic cancer Safety trial Tumor ablation Ultrasonography

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Managing spindle cell sarcoma with surgery and high-intensity focused ultrasound:A case report

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世界临床病例杂志 2023年第27期11卷 6551-6557页

作者： Ying-Qiong Zhu Gan-Chao Zhao Chen-Xi Zheng Lei Yuan Geng-Biao Yuan Department of Endocrinology People’s Hospital of FengjieFengjie 404600ChongqingChina Department of Oncology People’s Hospital of FengjieFengjie 404600ChongqingChina Department of Nuclear Medicine The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Endocrinology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Undifferentiated pleomorphic sarcomas,also known as spindle cell sarcomas,are a relatively uncommon subtype of soft tissue sarcomas in clinical *** SUMMARY We present a case report of a 69-year-old female patient who was diagnosed with undifferentiated spindle cell soft tissue sarcoma on her left *** excision was initially performed,but the patient experienced a local recurrence following multiple surgeries and radioactive particle ***-intensity focused ultrasound(HIFU)was subsequently administered,resulting in complete ablation of the sarcoma without any significant complications other than bone damage at the treated ***,approximately four months later,the patient experienced a broken lesion at the original *** further diagnostic workup,the patient underwent additional surgery and is currently stable with a good quality of *** HIFU has shown positive outcomes in achieving local control of limb spindle cell sarcoma,making it an effective non-invasive treatment option.

关键词： Spindle cell sarcoma high-intensity focused ultrasound Cancer therapy Case report

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Single application of high-intensity focused ultrasound as primary therapy of localized prostate cancer:Treatment-related predictors of biochemical outcomes

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Asian Journal of Urology 2015年第1期2卷 46-52页

作者： Dietrich Pfeiffer Juergen Berger Andreas Gross Department of Urology Asklepios Hospital Hamburg-BarmbekHamburgGermany Center of Experimental Medicine Institute of Medical Biometry and EpidemiologyUniversity Medical Center Hamburg-EppendorfHamburgGermany

Objective:Recent reports on high-intensity focused ultrasound(HIFU)treatment of localized prostate cancer suggest that preoperative risk groups of tumor recurrence are strong predictors of oncological *** purpose of this study is to determine the prognostic significance of treatment-related factors in relation to patient characteristics for biochemical outcomes after ***:This retrospective single-center study included patients treated from December 2002 to December 2010 for localized prostate cancer with two generations of AblathermHIFU devices(A1 and A2).All the patients underwent single HIFU treatment session under the concept of whole-gland *** surgery was performed before HIFU to downsize enlarged *** deprivation therapy(ADT)was discontinued before *** failure(BCF)was defined as prostate specific antigen(PSA)nadir t 1.2 ng/mL(Stuttgart definition).Predictors of BCF were determined using Cox regression *** covariates,patient-related factors(age,tumor characteristics,ADT)were compared with treatmentrelated factors(prostate volume,HIFU device generation,conduct of therapy,prostate edema,patient movement,anesthetic modalities).Results:Three hundred and twenty-three(98.8%)out of 327 consecutive patients were evaluable for ***(interquartile range)follow-up was 51.2(36.6e80.4)*** overall BCF-rate was 23.8%.In multivariate analyses,higher initial PSA-values(Hazard ratio[HR]:1.03;phigher D’Amico risk stages(HR:3.45;p<0.001)were patient-related predictors of *** treatment-related factors,the A2 HIFU device was associated with a decreased risk of BCF(HR:0.51;p Z 0.007),while prostate edema had an adverse effect(HR:1.8;p Z 0.027).Short follow-up and retrospective study design are the primary ***:Success in a single HIFU session depends not merely on tumor characteristics,but also on treatment-related *** is more efficacious with the technically a

关键词： Prostate cancer high-intensity focused ultrasound Efficacy Biochemical failure Prostate edema Patient movement

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The Efficacy of high-intensity focused ultrasound (HIFU) in Advanced Pancreatic Cancer

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Chinese Journal of Clinical Oncology 2008年第3期5卷 183-186页

作者： Bo Xie Jiajun Ling Weiming Zhang Xueqin Huang Jihua Zhen Yanzhe Huang Department of Oncology Guangzhou General Military Hospital Guangzhou 510010 Guangdong Province China. GuangZhou University of Chinese Medicine Guangzhou 510006Guangdong Province China.

OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU) in the treatment of late-stage pancreatic cancer. METHODS Sixteen patients with advanced pancreatic cancer received HIFU *** of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size. RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed. CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and *** is effective in killing the carcinoma cells and alleviating *** technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer.

关键词： high-intensity focused ultrasound pancreatic cancer pain treatment.

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Lax Facial Skin Treated with high-intensity focused ultrasound Devices: Efficacy and Safety Evaluations

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 1455-1472页

作者： Meng Wu Huan Chen Department of Dermatology Pofei Clinic Changsha China

Background: high-intensity focused ultrasound (HIFU) has been introduced to improve skin laxity in recent years. However, very few studies have evaluated the safety and effectiveness of HIFU in Chinese populations. Methods: In the study, 30 Chinese participants underwent HIFU (Bolida, Inc., Changsha, China) rejuvenation between February 1, 2022, and September 30, 2022. There were three different focal depths used depending on the area where shots were captured (4.5 mm, 4 MHz;3 mm, 7 MHz;1.5 mm, 7 MHz). After 3 months and 6 months of treatment, efficacy and safety were assessed by quantitative analysis. Results: Patients were satisfied with the clinical effects of HIFU rejuvenation after one session. In terms of effectiveness, HIFU was most successful in areas around the jawline, cheek, and perioral. In four cases, erythema was observed, in two cases, swollen gums were seen, but all of these effects were transient and mild. Conclusion: Bolida system can be safe and effective for facial tightening, additionally, they are most effective for jawline, cheek, and perioral improvements. In clinical practice, the Bolida system can be recommended as a reliable treatment option. .

关键词： high-intensity focused ultrasound Bolida System Treatment Efficacy Safety

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