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Protein & Cell 2014年第5期5卷 334-337页

作者： Lu Yu Wei Wang Shenglong Ling Yao He Liang Xiao Kaiqi Wu Longhua Zhang Changlin Tian Hefei National Laboratory for Physical Science at the Microscale School of Life Science University of Science and Technology of ChinaHefei 230026China high Magnetic Field Laboratory Chinese Academy of SciencesHefei 230031China

Dear Editor, Accurate measurement of distances within and between biological macromolecules is important for structure-function studies, for investigating conformational changes and dynamics, and for improving restraints for molecular dynamics and modeling programs （Hellmich and Glaubitz, 2009）. Several methods have been developed to measure the distances between atoms, residues, and domains in single proteins and larger complexes. Fluorescence reso- nance energy transfer （FRET） is currently the most fre- quently used method to derive distances in cells or protein complexes, but the bulky size of the fluorescence probes and the strict requirement for frequency profile overlap between the acceptor and donor chromophores are limita- tions in many cases （Prevo and Peterman, 2014）.

关键词： Distance high viscosity EPR

Sprayed Pickering emulsion with high antibacterial activity for wound healing

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Progress in Natural Science:Materials International 2020年第5期30卷 669-676页

作者： Xieru Bao Jie Wu Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences PLA Key Laboratory of Biopharmaceutical Production and Formulation Engineering Institute of Process Engineering Chinese Academy of Sciences Jiangsu National Synergetic Innovation Center for Advanced Materials

Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil’s antibacterial activity towards the Gram-negative Escherichia coli(E. coli),Gram-positive Staphylococcus aureus(S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus(MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing.

关键词： Pickering emulsion Wound healing Chitosan nanoparticles high viscosity Antibacterial activity

Experimental investigation of viscous oil-water-sand flow in horizontal pipes:Flow patterns and pressure gradient

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Petroleum 2024年第2期10卷 275-293页

作者： Tarek Ganat Petroleum and Chemical Engineering Department Sultan Qaboos UniversityP.O.Box 50Muscat 123Sultanate of Oman

Fluid production from unconsolidated reservoirs often leads in sand production,which poses a number of *** deposition in flowlines can result in significant pressure dips,pipe and facility damage,and obstructions that decrease *** research is needed to understand the movement and deposition of sand in oil-water-sand(O-W-S) *** article focuses on O-W-S flows in a 6-meter-long horizontal pipe with an inner diameter of 0.0381 *** study looks at the flow behavior of high viscosity oil-water(O-W),water-sand(W-S),and oil-water-sand(O-W-S) *** were carried out at 250 psig pressure in a laboratory flow test facility using various heavy synthetic oils(viscosities ranging from 3500 cP to 7500 cP at 25℃) and tap *** sand concentration varied from 1% to 10%,with an average sand particle diameter of 145 μm and material density of 2630 kg/m~*** cuts ranged from 0.0 to *** experimental results revealed a minor change in pressure gradient between(O-W) and(O-W-S) ***,increasing the sand concentration in(O-W-S) flow resulted in higher pressure *** reduction factor of pressure gradient indicated that the highest decrease in pressure drop occurred at higher superficial oil ***,a direct relationship was observed between the reduction factor and the decrease in water *** results also showed that the minimum required transportation velocity for sand slurry decreased with increasing superficial oil velocity,while the minimum transportation condition increased with higher sand *** comparison between the expected pressure gradient from Bannwart and McKibben et *** the actual experimental data demonstrated significant accuracy for the oil viscosities and superficial oil velocities used in the study.

关键词： Slurry velocity Flow pattern Pressure gradient high viscosity Minimum transport condition

A NEW EXPLICIT SIMULATION FOR MOULD FILLING WITH high VISCOUS FEEDSTOCK

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Acta Mechanica Solida Sinica 2004年第4期17卷 347-352页

作者： Cheng Zhiqiang Barriere Thierry Liu Baosheng Gelin Jean Claude Department of Applied Mechanics Southwest Jiaotong UniversityChengdu 610031China LMARC University of Franche-Comte and CNRS24 Chemin de l’′epitapheBesancon 25000France

In the simulation of the metal injection moulding (MIM), the behaviours of feedstock are much di?erent from which of the polymer injection. It is a mixture of the metallic powder in high concentration and some plastic binder. The advance in simulation of the mould ?lling with such high viscous feedstock is featured by the development of a fully explicit vectorial algorithm. On the basis of previous explicit software realized by the authors, the new algorithm avoids the global solution for pressure ?elds and the use of MINI elements to improve its e?ciency. Except for the operations at element level, neither global solution nor the construction of global matrix is required in simulation. A special strategy is used to regulate the incompressibility condition in ?lled domain at each time step. In case of the MIM problems, this method provides a fast way to simulate the ?lling processes. The computational cost is about linearly proportional to the degree of freedom number. Moreover, this vectorial algorithm can be easily parallelized for high performance computation with multi-clusters. The comparison of numerical results with previous simulations on 3D cases proves the validity and e?ciency of new algorithm.

关键词： mould filling high viscosity explicit simulation vectorial algorithm

Impact of Semen Liquefaction and viscosity on the Outcomes of in vitro Fertilization

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Journal of Reproduction and Contraception 2012年第3期23卷 169-178页

作者： Yan JIANG Qin-ying CAO Shu-xian LI Fan-yu MENG Cai-ping GENG Ge SONG Reproductive Medicine Center Department of Obstetries and Gynecology The Fourth Hospital of Shijiazhuang Shijiazhuang 050011 China

Objective To compare the outcomes of in vitro fertilization （IVF） and intracytoplasmic sperm injection （ICSI） between semen liquefaction and viscosity with normal and abnormal. Methods Semen that liquefied within 60 min and normal viscosity was assigned to the normal group, while semen that unliquefied more than 60 min or high viscosity was assigned to abnormal group. Equal volumes of culture medium were added to abnormal group and normal control group, followed by repeated pipetting, to induce liquefaction. Sperm parameters, fertilization and cleavage rates, good-quality embryo rate, im- plantation rate and pregnancy rate were analyzed. Results The abnormal group ratio was much higher in the ICSI group （30.5%） than in the IVF group （21.9%）（P〈0.05）. The age of the husbands and total progressive motility （PR） sperm in abnormal IVF group were higher than those in normal IVF group （P〈0.05）. Fertilization rate （80.7%） in the abnormal IVF group was higher than that in the normal IVF group （75.6%） and normal control group （P〈0.05）. There were no differences in outcomes of the ICSI patients between the normal and abnormal groups. There was no difference between normal group and normal control group. Conclusion Equal volume of culture media was added to non-liquefied semen may be used to high viscosity and unliquefied semen, and may have a positive effect on fertilization outcomes.

关键词： delayed liquefaction high viscosity IVF ICSI outcomes

Process Intensification of VOC Removal from high Viscous Media by Rotating Packed Bed

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Chinese Journal of Chemical Engineering 2009年第3期17卷 389-393页

作者：李沃源毋伟邹海魁初广文邵磊陈建峰 Research Center of the Ministry of Education for high Gravity Engineering and Technology College of Chemical EngineeringBeijing University of Chemical Technology

The removal of a volatile organic compound (VOC) from high viscous liquid was carried out in a rotat-ing packed bed (RPB) in this study. The mixed liquid of syrup and acetone was used as simulated high viscous polymer solution with acetone as the volatile compound. The influence of the rotating speed of RPB, liquid viscos-ity, liquid flow rate, vacuum degree, and initial acetone content in the liquid on acetone removal efficiency was in-vestigated. The experimental results indicated that the removal efficiency increased with increasing rotating speed and initial acetone content in the viscous liquid and decreased with increasing liquid viscosity and flow rate. It was also observed that acetone removal efficiency increased with an increasing vacuum degree and reached 58% at a vacuum degree of 0.1 MPa. By the comparison with a flash tank devolatilizer, it was found that acetone removal ef-ficiency in RPB increased by about 67%.

关键词： polymer devolatilization rotating packed bed high viscosity mass transfer volatile organic compound

Influence of viscosity in Fluid Atomization with Surface Acoustic Waves

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Open Journal of Acoustics 2016年第3期6卷 23-33页

作者： Andreas Winkler Paul Bergelt Lars Hillemann Siegfried Menzel IFW Dresden SAWLab Saxony Dresden Germany TU Dresden Institute for Process Engineering and Environmental Technology Dresden Germany

In this work, aqueous glycerol solutions are atomized to investigate the influence of the viscosity on the droplet size and the general atomization behavior in a setup using standing surface acoustic waves (sSAW) and a fluid supply at the boundary of the acoustic path. Depending on the fluid viscosity, the produced aerosols have a monomodal or polymodal size distribution. The mean droplet size in the dominant droplet fraction, however, decreases with increasing viscosity. Our results also indicate that the local wavefield conditions are crucial for the atomization process.

关键词： Surface Acoustic Waves Atomization Aerosol high viscosity Droplet Size Distribution Wavefield