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Investigation of process variables of high shear granulation on drug dissolution,characteristics and growth behaviour of granules containing nimodipine

Investigation of process variables of high shear granulation...

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生物颗粒与粉体制备、应用技术研讨会

作者：郭朕王思玲 Paul Wan Sia Heng 沈阳药科大学 Department of Pharmacy National University of Singapore117543 SingaporeSingapore

In order to study the correlation between the growth behaviour and dissolution rate of water-insoluble drug,Nimodipine,Microcrystalline cellulose(MCC) and aqueous Hydroxypropylcellulose were employed as model drug,filler and binder materials *** changes in the mean granule size and drug dissolution rate were monitored during granulation *** results obtained showed that the L/S ratio and impeller speed significantly affected the granule growth and drug dissolution rate *** dissolution rate sharply declined when consolidation was progressed and then leveled off at the equilibrium phase of granule *** general,it was concluded that the dissolution rate of water-insoluble drug of nimodipine is greatly related to the granule growth behaviour.

关键词： high shear granulation Nimodipine process parameter granule growth behaviour

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Investigation on the granulation behavior of iron ore fine in a horizontal high-shear granulator

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Particuology 2022年第9期20卷 57-64页

作者： Yang You Jiabao Guo Gang Li Zhuang Zheng Yong Li Yaowei Yu Xuewei Lv College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai 200444China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

high-shear granulation is widely used in many particulate industries for its good capability to improve the size,strength and composition uniformity of powder *** work conducted an experimental study to investigate the granulation behavior of iron ore fine in a horizontal high-shear granulator,such as granules size distribution,granules growth rate,and permeability of the granules *** results show that the granule size and permeability of packed granules bed increase gradually with increasing the granulation time,and the growth of granules can be divided into three stages:the rapid growth stage,the slow growth stage and the relatively stable *** the higher rotational speed and larger number of impellers increase the kinetic energy and collision frequency of the particles,which causes the increase of average granule size,growth rate and permeability of granules packed *** the other hand,the shear damage effect of the impellers on the granules is also enhanced with the increase of rotational speed and impeller number,resulting in significant granule size segregation.

关键词： high shear granulation Iron ore Particle Size distribution

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