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high density lipoproteins and atherosclerosis: emerging aspects

Journal of Geriatric Cardiology 2012年第4期9卷 401-407页

作者： Federica Sala Alberico Luigi Catapano Giuseppe Danilo Norata Department of Pharmacological Sciences University of Milan Via Balzaretti 9 Milan 20133 Italy IRCCSMult imedica ViaMilanese 300 Sesto San Giovanni Milan Italy Centro SISAper lo Studio dell’Aterosclerosi Ospedale Bassini Via Gorki50 Cinisello Bal samo Italy The Blizard Institute Barts and the LondonSchool of Medicine & Dentistry Queen Mary University Turner Street London E1 2AD UK

high density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis,includingmonocyte-macrophages, B and T ***, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.

关键词： Apolipoprotein high density lipoproteins Immune response Sphingosine-1-phosphate

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Metabolism of high density lipoproteins in liver cancer

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World Journal of Gastroenterology 2007年第23期13卷 3159-3163页

作者： Jing-Ting Jiang Ning Xu Chang-Ping Wu Department of Tumor Biological Treatment the Third Affiliated Hospital of Suzhou University Changzhou 213003 Jiangsu Province China Section of Clinical Chemistry & Pharmacology Lund University S-221 85 Lund Sweden

Liver plays a vital role in the production and catabolism of plasma lipoproteins. It depends on the integrity of cellular function of liver, which ensures homeostasis of lipid and lipoprotein metabolism. When liver ca... 详细信息

关键词： high density lipoproteins Metabolism Liver cancer

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Association of serum lipids and severity of epithelial ovarian cancer：an observational cohort study of 349 Chinese patients

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The Journal of Biomedical Research 2018年第5期32卷 336-342页

作者： Yi Zhang Jing Wu Junya Liang Xing Huang Lei Xia Dawei Ma Xinyu Xu Pingping Wu Department of Pathology Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China Department of Radiation Oncology Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China The School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China Department of Oncology Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research the Affiliated Cancer Hospital of Nanjing Medical University Nanjing Jiangsu 210009 China.

While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index（BMI）, lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics（FIGO） grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride（TG）, and high density lipoproteins（HDL） differed significantly among different stages of epithelial ovarian cancer（P〈0.05）. In the logistic regression model, elevated TG（OR： 1.883; 95% CI= 1.207-2.937）, and low HDL（OR： 0.497; 95% CI = 0.298-0.829） levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.

关键词： triglycerides epithelial ovarian cancer high density lipoproteins dyslipidemia clinical data statistics

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