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high birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children

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World Journal of Pediatrics 2020年第4期16卷 385-392页

作者： Jia-Ru Deng Wei-Qing Tan Shu-Yi Yang Li-Ping Ao Jian-Ping Liang Li-Xia Li Yan-Hui Gao Yi Yang Li Liu Department of Epidemiology and Biostatistics School of Public HealthGuangdong Pharmaceutical University283 Jianghai RoadGuangzhou510310China Guangzhou Health Care Promotion Center for Primary and Middle Schools Guangzhou510180China Futian Hospital for Prevention and Treatment of Chronic Disease Shenzhen518048China

Background high birth weight(HBW)is associated with childhood obesity,but with inconsistent *** study investigated the relationship between HBW and childhood obesity,and further explored the interaction of HBW with behavioral and socio-economic determinants of *** This cross-sectional study enrolled 1906 grade-two children of Guangzhou,China,from June to November,***/obesity corresponded to a body mass index higher than the sex–age-specific *** obesity was assessed using the sex-specific waist–height ratio *** association of HBW with obesity was evaluated in multivariable logistic regression *** relative excess risk due to interaction(RERI)and the attributable proportion of interaction(AP)indices were used to measure additive interaction,while applying the interaction of OR index for multiplicative interaction *** Children with HBW had an increased risk of overweight/obesity[odds ratio(OR)=2.42,95%confidence interval(CI)=1.56–3.76]compared with those without *** additive interaction of HBW with physical activity was found for overweight/obesity[relative excess risk due to interaction(RERI)=2.69,95%CI=0.62–4.75;attributable proportion of interaction(AP)=0.72,95%CI=0.42–1.02].The HBW children with insufficient activity had higher odds of overweight/obesity compared to the non-HBW children with sufficient activity(OR=3.75,95%CI=2.06–6.83).In addition,we identified a significant interaction of HBW with household income for abdominal obesity(RERI=1.20,95%CI=0.02–2.37;AP=0.76,95%CI=0.16–1.36).Conclusions HBW confers an increased risk for childhood overweight/*** activity attenuates the effect of HBW on overweight/obesity,and HBW possibly synergistically interacts with high household income to promote abdominal obesity in childhood.

关键词： Childhood high birth weight Interaction Obesity Physical activity

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