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Risk Factors for Cancer Chemotherapy-Induced hiccups (CIH)

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Pharmacology & Pharmacy 2018年第8期9卷 331-343页

作者： Ryuichiro Hosoya Ippei Tanaka Reiko Ishii-Nozawa Takeshi Amino Tomoyuki Kamata Seiichi Hino Hajime Kagaya Yoshihiro Uesawa Department of Medical Molecular Informatics Meiji Pharmaceutical University Kiyose Japan Department of Pharmacy Japanese Red Cross Musashino Hospital Musashino Japan Department of Clinical Neuropharmacology Meiji Pharmaceutical University Kiyose Japan Department of Neurology Japanese Red Cross Musashino Hospital Musashino Japan Department of Clinical Pharmaceutics Meiji Pharmaceutical University Kiyose Japan

Background: hiccups are common somatic side effects of medication. Our previous analysis of the clinical risk factors for hiccups identified chemotherapy as a factor related to hiccup risk. Therefore, in the present study, we investigated the risk factors for hiccups associated with chemotherapy. Methods: We included all patients who received cancer chemotherapy and were hospitalized at the Musashino Red Cross Hospital between April 2014 and December 2014. We investigated patient demographics, physical characteristics, and other clinical factors to identify the risk factors for chemotherapy-induced hiccups (CIH). We conducted univariate and multivariable analysis to compare the CIH group and the non-CIH and determined risk factors of CIH. Results: hiccups were identified in 48 of 292 patients with an incidence rate of 16.4%. Univariate analysis revealed that the male gender, pain, and nausea and vomiting were related to CIH. It also showed that cisplatin, pemetrexed, gemcitabine, etoposide, dexamethasone, and metoclopramide were related to CIH.A correlation which was found with doses of cisplatin, pemetrexed, gemcitabine, and etoposide. Multivariable analysis identified male gender (OR, 72.69;95% CI, 6.95 - 757.64), nausea and vomiting (OR, 52.01;95% CI, 3.93 - 447.13), dexamethasone (OR, 4.55;95% CI, 1.12 - 16.91), cisplatin (OR, 3.84;95% CI, 1.52 - 9.70), and etoposide (OR, 3.72;95% CI, 1.14 - 12.11) as independent risk factors for hiccups. Conclusions: The present study is the first one to report risk factors for the development of CIH. Our results suggest that male gender, having nausea, and the drugs dexamethasone, cisplatin, and etoposide are important risk factors for CIH. These results may assist in elucidation of the underlying mechanisms and guide therapy to reduce hiccup risk.

关键词： hiccups Chemotherapy Adverse Effects Cancer Risk Factors

Intractable hiccups, an Unusual Presentation of Renal Cell Carcinoma

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Open Journal of Urology 2022年第5期12卷 271-275页

作者： Isaac Obeng Asiedu James Edward Mensah Bernard Toboh Marian Harrison Ekins Kuuzie Matthew Kyei Yaw Amoah Kenneth Klufio Department of Urology Korle Bu Teaching Hospital Accra Ghana

hiccups are involuntary spasms of the diaphragm with closure of the glottis. This involves a complex neural pathway which includes the phrenic, vagus and the sympathetic pathways, it is usually self-limiting and resolves within a few minutes after onset. hiccups are described as chronic when it lasts more than 48 hours and intractable when it persists for more than a month. Intractable hiccups are said to have an organic cause in 80% of cases and the remaining 20% psychogenic in origin, Some of the organic causes of intractable hiccups include: liver cancer, adrenal tumours, and kidney tumours. We present a case of right renal cell carcinoma which presented as intractable hiccups and was successfully managed by performing a radical right nephrectomy.

关键词： hiccups Intractable hiccups Renal Tumour Case Report

Clinical Observation on the Application of Scalp and Body Acupuncture in Treating Post-stroke hiccups

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Journal of Acupuncture and Tuina Science 2011年第3期9卷 177-178页

作者：丁明桥洪珏 Fifth Hospital of Wuhan

hiccups are a common complication following stroke,characterized by gastric air reflux,causing an involuntarily frequent short"hic"*** adopted scalp and body acupuncture to treat78cases of post-stroke hiccups during A... 详细信息

关键词： Scalp Acupuncture Acupuncture Therapy Stroke Complications hiccups

Postoperative Hiccup Induced by LMA—A Case Report with Literature Review

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Open Journal of Anesthesiology 2014年第10期4卷 236-239页

作者： C. C. Nwagwu L. N. Ebirim Department of Anaesthesia Niger Delta University Teaching Hospital Okolobiri Nigeria Department of Anaesthesiology University of Port Harcourt Teaching Hospital Port Harcourt Nigeria

Background: The laryngeal mask airway (LMA) has become popular due to simplicity of its use and its important function in difficult airway management. However, some complications have been associated with its use. A case report and review of literature on hiccups associated with the use of LMA is presented. Case Report: A 24-year-old man who presented with a right inguinoscrotal hernia was scheduled for elective surgery under general anaesthesia. He denied any co-existing medical illness. Physical examination showed a normal healthy patient and he was placed in class 1 of the American Society of Anesthesiologist (ASA) physical status category. After premedication with 0.6 mg atropine, general anaesthesia was induced with 200 mg of intravenous propofol. Size 5 classic LMA was inserted, and surgery had lasted for 45 minutes. He had hiccups immediately after removal of the LMA which lasted for 6 minutes, and stopped about 95 seconds after 0.6 mg intravenous atropine was given. Conclusion: Complications from the use of LMA may be rare but still possible. It is important to adhere to the guidelines for insertion and removal of the LMA and perioperative use of the device should strictly be by trained personnel.

关键词： Laryngeal Mask Airway Post-Operative hiccups