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Aberrant expression of nuclear matrix proteins during HMBA-induced differentiation of gastric cancer cells

World Journal of Gastroenterology 2010年第17期16卷 2176-2182页

作者： Jing, Guang-Jun Xu, Dong-Hui Shi, Song-Lin Li, Qi-Fu Wang, San-Ying Wu, Fu-Yun Kong, Hai-Yan Xiamen Univ Key Lab Minist Educ Cell Biol & Tumor Cell Engn Sch Life Sci Xiamen 361005 Fujian Province Peoples R China Xiamen Univ Dept Hepat Biliary Pancreat Vasc Surg Affiliated Hosp 1 Xiamen 361003 Fujian Province Peoples R China

AIM: To investigate the aberrant expression of nuclear matrix proteins in human gastric cancer cells before and after hexamethylene bisacetamide (HMBA) ***: Proteomics analysis of differential nuclear matrix proteins was performed by two dimensional electrophoresis polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass *** expression levels of three nuclear matrix proteins were further confirmed by Western blotting and their locations in nuclear matrix filament were observed by quantum dots-based ***: Proteomics analysis showed that 43 protein spots were significantly changed due to HMBA *** proteins were identified in the HMBAinduced differentiation of gastric tumor *** proteins spots were down-regulated while seven were *** these proteins,prohibitin,nucleophosmin and hnRNP A2/B1 were significantly decreased in HMBA-treated human gastric cancer cells,and their locations in nuclear matrix were altered by *** results proved the alteration of specific nuclear matrix proteins during the differentiation of human gastric cancer *** the aberrant expressions of nuclear matrix proteins were of significance in revealing the regulatory mechanism of tumor cell proliferation and ***: The aberrant expressions and intracellular redistributions of nuclear matrix proteins before and after HMBA treatment indicated that nuclear matrix proteins play a pivotal role in the differentiation of gastric cancer cells.

关键词： Human gastric tumor cell hexamethylene bisacetamide Differentiation Nuclear matrix Proliferation

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HMBA-induced differentiation of myeloid leukemic cell lines is assoc iated with altered G1 cell cycle regulators and related genes

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Chinese Medical Journal 2004年第3期117卷 453-455页

作者：王钦红谢毅范华骅 Department of Hematology Huashan Hospital Medical Center of Fudan University Blood Engineering Lab of Shanghai Blood Center

The proliferation and differentiation of hematopoietic cells can be regulated by a number of physiological agents including hexamethylene bisacetamide (HMBA). Clinically, HMBA has been used for the treatment of acute myeloid leukemia and myelodysplastic syndrome.1 However, the mechanism of the effect of HMBA on the differentiation of myeloid leukemic cells is largely unkown. Up to now, related reports have not been found. We used HL-60 and U937 cell lines to study the effect of HMBA on the differentiation of myeloid leukemic cells and to explore the possible mechanism.

关键词： hexamethylene bisacetamide cell differentiation· cell cycle

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