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Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine via the splenic vein

World Journal of Gastroenterology 2018年第44期24卷 5005-5012页

作者： Yan-Yan Zhang Chao-Xu Zhang Yu Li Xuan Jiang Yong-Fang Wang Yang Sun Jun Wang Wan-Ying Ji Yi Liu Medical Imaging Center The Affiliated Hospital of Liaoning Traditional Chinese Medical University Department of Radiology The First Hospital of China Medical University Department of Medical Oncology The First Hospital of China Medical University Department of Cardiac Surgery The First Hospital of China Medical University

AIM To develop a novel rat model of heterogeneous hepatic *** Seventy male Sprague-Dawley rats were randomly divided into a control group(n = 10) and a colchicine group(n =60). A 0.25% colchicine solution(0.4 mL/kg) was injected via the splenic vein in the colchicine group to develop a rat model of heterogeneous hepatic injury. An equal volume of normal saline was injected via the splenic vein in the control group. At days 3, 7, and 14 and weeks 4, 8, and 12 after the operation, at least seven rats of the colchicine group were selected randomly for magnetic resonance imaging(MRI) examinations, and then they were euthanized. Ten rats of the control group underwent MRI examinations at the same time points, and then were euthanized at week 12. T2-weighted images(T2 WI) and diffusion weighted imaging(DWI) were used to evaluate the heterogeneous hepatic injury. The heterogeneous injury between the left and right hepatic lobes was assessed on liver sections according to the histological scoring criteria, and correlated with the results of MRI study. RESULTS Obvious pathological changes occurred in the hepatic parenchyma in the colchicine group. hepatic injury scores were significantly different between the left and right lobes at each time point(P hepatic injury scores and ADC values or LMR(r =-0.682, P = 0.000; r =-0.245, P = 0.018).CONCLUSION Injection with colchicine via the splenic vein can be used to successfully develop a rat model of heterogeneous hepatic injury. DWI and T2 WI may help evaluate the heterogeneous injury among liver lobes.

关键词： heterogeneous hepatic injury Rat model Colchicine T2-weighted images Diffusion weighted imaging

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