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Severe liver injury due to herbal and dietary supplements and the role of liver transplantation

World Journal of Gastroenterology 2019年第46期25卷 6704-6712页

作者： Priya Grewal Jawad Ahmad Division of Liver Diseases Icahn School of Medicine at Mount Sinai

herbal and dietary supplements(HDS)are increasingly used worldwide for numerous,mainly unproven health *** HDS industry is poorly regulated compared to prescription medicines and most products are easily *** induced liver injury(DILI)is a well-recognized entity associated with prescription and over the counter medications and many reports have emerged of potential HDS-related *** is considerable geographic variability in the risk and severity of DILI associated with HDS but the presentation of severe liver injury is similar with a hepatocellular pattern accompanied by *** type of injury can lead to acute liver failure and the need for liver *** will often fail to mention their use of HDS,considering it natural and therefore *** physicians should understand that these products can be associated with DILI and explicitly ask about HDS use in any patient with otherwise unexplained acute liver injury.

关键词： herbal and dietary supplements Drug induced liver injury Liver transplantation Acute liver failure Geographic variability

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Liver Injury from herbal, dietary, and Weight Loss supplements: a Review

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Journal of Clinical and Translational Hepatology 2015年第2期3卷 93-98页

作者： Elizabeth X.Zheng Victor J.Navarro Einstein Medical Center Philadelphia PA USA

herbal and dietary supplement usage has increased steadily over the past several years in the United *** the non-bodybuilding herbal and dietary supplements,weight loss supplements were among the most common type of HDS implicated in liver *** drug induced liver injury is rare,its consequences are significant and on the *** purpose of this review is to highlight case reports of weight loss products such as Hydroxycut and OxyElite Pro as one form of HDS that have hepatotoxic potential and to characterize its clinical effects as well as pattern of liver *** also propose future strategies in the identification and study of potentially hepatotoxic compounds in an effort to outline a diagnostic approach for identifying any drug induced liver injury.

关键词： Drug induced liver injury herbal and dietary supplements Weight loss supplements

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