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Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats

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Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 289-293页

作者： Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical SciencesUniversity of NigeriaNsukka41001Enugu StateNigeria

Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (***) leaf ***:Various solvent fractions of the methanol extract of the leaf of the *** ***(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in *** degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total *** in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging *** extract was subjected to preliminary phytoehemical ***:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the *** effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic ***,flavonoids,saponins and tannins were delected in the phylochemical ***:From this study,it was concluded that the plant of *** possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract.

关键词： Alchornea cordifolia Antioxidant Carbon tetrachloride DPPH model hepatoprolective Phytochemical analysis

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