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Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study

World Journal of Gastroenterology 2021年第14期27卷 1435-1450页

作者： Marwa Matboli Amany H Hasanin Reham Hussein Sarah El-Nakeep Eman K Habib Rawan Ellackany Lobna A Saleh Department of Biochemistry Ain Shams Faculty of MedicineCairo 11318Egypt Department of Clinical Pharmacology Ain Shams Faculty of MedicineCairo 11381Egypt Department of General Internal Medicine Ain Shams Faculty of MedicineCairo 11381Egypt Department of Anatomy&Embryology Ain Shams Faculty of MedicineCairo 11318Egypt Department of Undergraduate Faculty of MedicineModern University for Technology and InformationCairo 11381Egypt

BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer *** cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular *** To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar *** In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain *** examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were *** Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver ***,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle *** note,cyan decreased GSTP foci percent area and PCNA positively stained *** Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle.

关键词： hepatocellular carcinoma therapy hepatocellular-carcinoma growth hepatocellular-carcinoma model hepatocellular-carcinoma size

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