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Decaprenyl diphosphate synthase subunit 2 as a prognosis factor in hepatocellular carcinoma

World Journal of Gastroenterology 2015年第10期21卷 3055-3065页

作者： Wei Huang Fei Gao Kang Li Wen Wang Ya-Rou Lai Shao-Hui Tang Dong-Hua Yang Department of Gastroenterology The First Affiliated Hospital of Jinan University Department of Gastroenterology Panyu Hexian Memorial Hospital

AIM:To investigate the involvement of decaprenyl diphosphate synthase subunit 2(PDSS2) in development and progression of human hepatocellular carcinoma(HCC).METHODS:PDSS2 protein expression was examined in well-and poorly differentiated HCC tumor *** levels of PDSS2 expression were compared with clinical features and prognosis of HCC *** effects of PDSS2 on cell proliferation,cell cycle,apoptosis,cell migration,and invasion in HCC Hep G2 cells were also ***:PDSS2 was downregulated in poorly differentiated cancer samples compared with welldifferentiated tumor samples,and the expression level was markedly lower in HCC tissues than in histologically normal tissue adjacent to the *** protein expression was negatively associated with the status of HCC *** addition,overexpression of PDSS2dramatically suppressed cell proliferation and colony formation,and induced apoptosis in Hep G2 cells by inducing G1-phase cell-cycle *** migration and invasion capabilities of Hep G2 cells were significantly decreased following PDSS2 ***:Decreased PDSS2 expression is an unfavorable prognostic factor for HCC,and PDSS2 has potent anticancer activity in HCC tissues and Hep G2cells.

关键词： Decaprenyl diphosphate synthase subunit 2 hepatoce

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