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hepatobiliary scintigraphy for detecting biliary strictures after living donor liver transplantation

World Journal of Gastroenterology 2011年第21期17卷 2626-2631页

作者： Yu Jin Kim Kyu Taek Lee Young Cheol Jo Kwang Hyuck Lee Jong Kyun Lee Jae-Won Joh Choon Hyuck David Kwon Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the diagnostic accuracy of hepatobiliary scintigraphy(HBS) in detecting biliary strictures in living donor liver transplantation(LDLT) ***:We retrospectively reviewed 104 adult LDLT recipients of the right hepatic lobe with duct-toduct anastomosis,who underwent HBS and *** HBS results were categorized as normal,parenchymal dysfunction,biliary obstruction,or bile leakage without *** presence of biliary strictures was determined by percutaneous cholangiography or endoscopic retrograde cholangiopancreatography(ERCP).RESULTS:In 89 patients with biliary strictures,HBS showed biliary obstruction in 50 and no obstruction in 39,for a sensitivity of 56.2%.Of 15 patients with no biliary strictures,HBS showed no obstruction in 11,for a specificity of 73.3%.The positive predictive value(PPV) was 92.6%(50/54) and the negative predictive value(NPV) was 22%(11/50).We also analyzed the diagnostic accuracy of the change in bile duct *** sensitivity,NPV,specificity,and PPV were 65.2%,27.9%,80% and 95%,***:The absence of biliary obstruction on HBS is not ***,when post-LDLT biliary strictures are suspected,early ERCP may be considered.

关键词： Living donor liver transplantation Tc99m mebrofenin Radionucleotide imaging hepatobiliary scintigraphy Biliary stricture

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The role of 99mTc-EHIDA hepatobiliary scintigraphy in the diagnosis of gallbladder motility and gallstone formation in patients with Liver cirrhosis

The role of 99mTc-EHIDA hepatobiliary scintigraphy in the di...

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首届全国分子核医学暨分子影像学学术交流会

作者： YANG Ji-gang, LI Chun-lin, HAO Rui-rui,WANG Hui-ji,ZOU Lan-fang Nuclear Medicine Department, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences Comprehensive Department, Beijing Friendship Hospital, Beijing 100050,China.

Aims To investigate the gallbladder motility in patients with liver cirrhosis and the relationship between gallbladder motility function and gallstone, then provide basis in choosing suitable method in the diagnosis of gallbladder motility disorder, prevention and cure liver cirrhosis combination gallstones. Subjects and Methods The study included two groups: 14 normal subjects, 62 patients with cirrhosis, 15 cirrhosis patients with gallstones, 47 cirrhosis patients without gallstone. Patients were divided into cirrhosis with gallstones and without gallstone through B ultrasound. Every normal subject received inquisition, physical examination, and B ultrasound in the condition of fasting. All normal subjects didn’t have the history of liver disease, pancreas and biliary tract system diseases, without peptic ulcer, abdomen operation and diabetes mellitus history et al. There were no significances in age and sex between cirrhosis patients and normal subjects. All subjects received 99mTc-EHIDA hepatobiliary scintigraphy in nuclear medicine department of Beijing friendship hospital between June 2004 and February 2005. After an 8-12-hour fast, each subject was given 185MBq(5mCi) of 99mTc-EHIDA intravenously. 60mins after injection, every subject lies supine under a large-field γ-camera fitted with a low-energy parallel collimator. Serial hepatobiliary analog images were taken for 65mins at 1-min intervals. These patients ate a standard 200ml liquid fatty meal within l-2mins in 3mins after acquisition. Two regions on interest (ROIs) were chosen: ROI1, over the entire gallbladder;ROI2, over the entire liver. Time-activity curves were generated for both ROIs and the counts were corrected for physical decay: latent period (LP), ejection period (EP), gallbladder ejection fraction (GBEF), and ejection rate (ER). Results The image of liver 60mins after injection is clear with high background counts and the counts of gallbladder region are high in cirrhosis patients, the liver i

关键词： Cirrhosis Gallbladder Motility Gallstone hepatobiliary scintigraphy

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Gallbladder function and dynamics of bile flow in asymptomatic gallstone disease

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World Journal of Gastroenterology 2009年第22期15卷 2763-2767页

作者： Sevim Süreyya eri Feride Meltem zbek Celal eri Bahattin Baykal Hasan Erol Eroglu Zeynep Baykal Mustafa Yildiz Semahat Saglam Ahmet Yesildag Nuclear Medicine University of Suleyman Demirel Hospital General Surgery University of Suleyman Demirel Hospital Radiology University of Suleyman Demirel Hospital Internal Medicine State Hospital Isparta

AIM： To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymptomatic gallstone disease. METHODS： Quantitative hepatobiliary scintigraphy was performed to detect the parameters of gallbladder motor function [gallbladder ejection fraction （GBEF）, gallbladder visualization time （GBVT）, gallbladder time to peak activity （GBTmax）, gallbladder half emptying time （GBT1/2）, and transit time of bile to duodenum （TTBD）] in 24 patients with asymptomatic cholelithiasis who were diagnosed incidentally during routine abdominal ultrasonographic examination and 20 healthy subjects with normal gallbladder. RESULTS： Even though there was no significant difference in the clinical and laboratory parameters between the patient and control groups, all parameters of gallbladder function except TTBD were found to differ significantly between the two groups. GBEF in the patient group was decreased （P = 0.000） and GBVT, GBT GBT1/2 in the patient group were longer （P = 0.000, P = 0.015, P = 0.001, respectively）.there were not any clinical and laboratory findings, gallbladder filling and emptying could be impaired in patients with gallstone disease.

关键词： Asymptomatic gallstone disease hepatobiliary scintigraphy Gallbladder function

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