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Novel cellular therapies for hepatobiliary malignancies

hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 450-454页

作者： Jing-Nan Xue Yan-Yu Wang Yun-Chao Wang Nan Zhang Long-Hao Zhang Zheng-Hui Lu Li-Jin Zhao Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of hepatobiliary and Pancreatic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China hepatobiliary and Pancreatic Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China

Background:The mortalities of hepatobiliary malignancies are *** the failure of conventional chemotherapy and unsatisfactory outcome of molecular targeted drugs,immune-based therapy has become a new focus of research in hepatobiliary cancers *** sources:We performed a Pub Med search with relevant articles published up to May 2022 and the following keywords:cellular immunotherapy,hepatobiliary cancer,antigen receptor T cell therapy,and receptor-engineered T *** of clinical trials was obtained from https://***/.Results:Cell therapies for hepatobiliary malignancies are at early stage of *** current review showed that cellular therapies are safe and feasible in *** findings provide an important platform for future lager scale clinical trials on immunotherapy in patients with hepatobiliary ***:With the continuous advances of cellular immunotherapy,the combination of cellular immunotherapy with surgery,chemotherapy and radiotherapy will be new therapeutic strategies for patients with hepatobiliary cancer.

关键词： Cellular therapy Chimeric antigen receptor T cell therapy Receptor-engineered T cell hepatobiliary malignancy

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An Update to hepatobiliary Stents

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Journal of Clinical and Translational Hepatology 2015年第1期3卷 67-77页

作者： Brian T.Moy John W.Birk Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT USA

Endoscopic stent placement is a common primary management therapy for benign and malignant biliary ***,continuous use of stents is limited by occlusion and *** technology has evolved significantly over the past two decades to reduce these *** purpose of this article is to review current guidelines in managing malignant and benign biliary obstructions,current endoscopic techniques for stent placement,and emerging stent *** began as a simple plastic stent technology has evolved significantly to include uncovered,partially covered,and fully covered self-expanding metal stents (SEMS) as well as magnetic,bioabsorbable,drug-eluting,and antireflux stents.

关键词： Biliary obstruction Stent hepatobiliary malignancy Liver hilum

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