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Screening and prevention of hepatitis C virus reactivation during chemotherapy

World Journal of Gastroenterology 2021年第31期27卷 5181-5188页

作者： Yuan-Rung Li Tsung-Hui Hu Wen-Chi Chen Ping-I Hsu Hui-Chun Chen Department of Internal Medicine Kaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Internal Medicine Chang Gung University College of MedicineKaohsiung 833Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 833Taiwan

hepatitis C virus(HCV)reactivation occurs in 23%of HCV-infected cancer patients receiving ***-three percent of the patients with reactivation of HCV during chemotherapy develop a hepatitis *** of the cancer patients with HCV reactivation have an unremarkable clinical course following an HCV-related hepatitis flare during ***,26%–57%of the cancer patients developing an acute flare of chronic hepatitis C during chemotherapy require unanticipated discontinuation or dose reduction of chemotherapy,which results in deleterious changes in the cancer treatment *** an optimal strategy for HCV screening in cancer patients receiving chemotherapy has not been established,universal pre-chemotherapy HCV testing for patients with hematological malignancies is recommended by current *** the currently approved direct-acting antivirals(DAAs)can be used in cancer patients,but the use of DAAs during chemotherapy should avoid drug–drug interactions between chemotherapy and antiviral *** there are no contraindications or anticipated drug–drug interactions,DAAs treatment can be administered before,during,or after *** conclusion,HCV reactivation occurs in approximately one-fourth of HCV-infected cancer patients receiving *** HCV-related hepatitis flare during chemotherapy may lead to the discontinuation of potentially life-saving ***,universal HCV screening is recommended in hematological malignancy patients before chemotherapy,but there is no evidence-based guideline for other cancer *** treatment can cure HCV infection and prevent HCV reactivation during chemotherapy.

关键词： hepatitis C virus Chemotherapy Screening Reactivation hepatitis flare

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