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Role of macrophages and monocytes in hepatitis c virus infections

World Journal of Gastroenterology 2014年第11期20卷 2777-2784页

作者： Dennis Revie Syed Zaki Salahuddin Department of Biology California Lutheran UniversityThousand OaksCA 91360United States california Institute of Molecular Medicine VenturaCA 93003United States

A number of studies conducted over many years have shown that hepatitis c virus(HcV)can infect a variety of cell *** vivo infection of monocytes,macrophages,and dendritic cells by HcV has been frequently shown by a number of *** studies have demonstrated replication of HcV by detecting the presence of both negative genomic strands and a variety of non-structural HcV proteins in infected *** addition,analyses of genome sequences have also shown that different cell types can harbor different HcV *** have also done preliminary studies of which cellular genes are affected by HcV infection,but there have not yet been a sufficient number of these studies to understand the effects of infection on these *** of in vitro HcV replication have shown that monocytes,macrophages and dendritic cells can be infected by HcV from patient sera or *** studies suggest that entry and cellular locations may vary between different cell *** studies suggest that macrophages may preferentially allow HcV genotype 1 to replicate,but macrophages do not appear to select particular hypervariable ***,these studies agree with a model where monocytes and macrophages act as an amplification system,in which these cells are infected and show few cytopathic effects,but continuously produce *** allows them to produce virus over an extended time and allows its spread to other cell types.

关键词： hepatitis c virus Macrophages Monocytes Dendritic cells hepatitis c virus replication

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