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Genotype specific peripheral lipid profile changes with hepatitis c therapy

World Journal of Gastroenterology 2016年第46期22卷 10226-10231页

作者： Mark R Pedersen Amit Patel David Backstedt Myunghan choi Anil B Seetharam Department of Internal Medicine Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Department of Gastroenterology Banner University Medical Center University of Arizona College of Medicine Phoenix AZ 85006 United States Arizona State University college of Nursing and Health care Innovation Banner Phoenix AZ 85006 United States Transplant and Advanced Liver Disease center University of Arizona College of Medicine Phoenix AZ 85006 United States

AIM To evaluate magnitude/direction of changes in peripheral lipid profiles in patients undergoing direct acting therapy for hepatitis c by *** Mono-infected patients with hepatitis c were treated with guideline-based DAAs at a university-based liver clinic. Patient characteristics and laboratory values were collected before and after the treatment period. Baseline demographics included age, ethnicity, hypertension, diabetes, hyperlipidemia, treatment regimen, and fibrosis stage. Total cholesterol(TcHOL), high density lipoprotein(HDL), low density lipoprotein(LDL), triglycerides(TG), and liver function tests were measured prior to treatment and ETR. changes in lipid and liver function were evaluated by subgroups with respect to genotype. Mean differences were calculated for each lipid profile and liver function component(direction/magnitude). The mean differences in lipid profiles were then compared between genotypes for differences in direction/magnitude. Lipid profile and liver function changes were evaluated with Levene's test and student's t test. Mean differences in lipid profiles were compared between genotypes using ANOVA, post hoc analysis via the Bonferroni correction or Dunnett *** Three hundred and seventy five patients enrolled with 321(85.6%) achieving sustained-viral response at 12 wk. 72.3% were genotype 1(GT1), 18.1% genotype 2(GT2), 9.7% genotype 3(GT3). Baseline demographics were similar. Significant change in lipid profiles were seen with GT1 and GT3(ΔGT1, p and ΔGT3, p), with TcHOL increasing(+5.3, P = 0.005 and +16.1, P creasing(+12.5, P creasing(+7.4, P = 0.058 and +12.5, P creasing(-5.9, P = 0.044 and-9.80 P = 0.067). Among genotypes(ΔGT1 v. ΔGT2 v. ΔGT3, ANOVA), significant mean differences were seen with TcHOL(+5.3 v. +0.1 v. +16.1, P = 0.017) and HDL(+12.3 v. +2 v. +7.9, P = 0.040). Post-hoc, GT3 was associated with a greater increase in TcHOL than GT

关键词： hepatitis c genotypes Lipids Metabolic syndrome

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