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Progress in hepatitis b virus-related acute-on-chronic liver failure treatment in China:A large,multicenter,retrospective cohort study using a propensity score matching analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 535-541页

作者： Lan-Lan Xiao Xiao-Xin Wu Jia-Jia Chen Dong Yan Dong-Yan Shi Jian-Rong Huang Xiao-Wei Xu Lan-Juan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang UniversityHangzhou 310003China

background:hepatitis b virus-related acute-on-chronic liver failure(HbV-ACLF)has a high short-term ***,the treatment progression for HbV-ACLF in China in the past decade has not been well *** present study aimed to determine whether the HbV-ACLF treatment has significantly improved during the past ***:This study retrospectively compared short-term(28/56 days)survival rates of two different nationwide cohorts(cohort I:2008-2011 and cohort II:2012-2015).Eligible HbV-ACLF patients were enrolled *** in the cohorts I and II were assigned either to the standard medical therapy(SMT)group(cohort I-SMT,cohort II-SMT)or artificial liver support system(ALSS)group(cohort IALSS,cohort II-ALSS).Propensity score matching analysis was conducted to eliminate baseline differences,and multivariate logistic regression analysis was used to explore the independent factors for 28-day ***:Short-term(28/56 days)survival rates were significantly higher in the ALSS group than those in the SMT group(Pboth SMT(60.7%vs.53.0%,50.0%vs.39.8%,Pbilirubin(OR=1.002,95%CI:1.001-1.003,P=0.004),INR(OR=1.569,95%CI:1.044-2.358,Pbumin(OR=0.952,95%CI:0.924-0.982,P=0.002)were independent factors for 28-day ***:The treatment for patients with HbV-ACLF has improved

关键词： hepatitis b virus-related acute-on-chronic liver failure Propensity score matching analysis Short-term survival rate Standard medical therapy Artificial liver support system

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Changes in circulating Foxp3^+ regulatory T cells and interleukin-17-producing T helper cells during HbV-related acute-on-chronic liver failure

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World Journal of Gastroenterology 2014年第26期20卷 8558-8571页

作者： Xue-Song Liang Cheng-Zhong Li Yin Zhou Wei Yin Ya Yun Liu Wen-Han Fan Department of Infectious Diseases Changhai HospitalSecond Military Medical University Department of biochemistry and Molecular biology College of Basic Medical SciencesSecond Military Medical University

AIM: To longitudinally investigate cytokine gene expression and protein levels in Th17 and Treg cells, to observe T-cell phenotypes during hepatitis b virus (HbV)-related acute-on-chronic liver failure (ACHbLF) and to... 详细信息

关键词： hepatitis b virus Treg Th17 Immune hepatitis b virus-related acute-on-chronic liver failure

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