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Anti-OX40 Antibody Combined with Hbc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU Jia Jia SU Qiu Dong YI Yao SHEN Li Ping bI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis b core viruslike particles(Hbc VLPs)therapy using a mouse colon cancer *** Humanized b-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with Hbc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with Hbc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that Hbc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with Hbc *** Combination therapy of anti-h OX40 and Hbc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody hepatitis b core virus-like particles Tumor Combination therapy

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