检索结果-南通市图书馆

Serum hepatitis b core-related antigen as a surrogate marker of hepatitis b e antigen seroconversion in chronic hepatitis b

引用

World Journal of Gastroenterology 2021年第40期27卷 6927-6938页

作者： Xiu-Mei Chi Xiao-Mei Wang Zhong-Feng Wang Rui-Hong Wu Xiu-Zhu Gao Hong-Qin Xu Yan-Hua Ding Jun-Qi Niu Department of Hepatology Key Laboratory of Zoonosis ResearchMinistry EducationThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Phase I Clinical Trials Unit The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

bACKGROUND Quantitative hepatitis b core-related antigen(qHbcrAg)has a better correlation with intrahepatic hepatitis b virus(HbV)covalently closed circular DNA(cccDNA)than HbV DNA or hepatitis b e antigen(HbeAg),but data are still lacking for its clinical *** The aim was to investigate serum qHbcrAg levels in patients with chronic hepatitis b and assess the correlation of serum qHbcrAg with pregenomic RNA(pgRNA),cccDNA,and HbeAg *** This study was a secondary analysis of patients who underwent percutaneous liver biopsy between July 2014 and June 2019 in two multicenter randomized controlled clinical trials of peginterferon vs nucleos(t)ide analog(NUC)-based therapy(NCT03509688 and NCT03546530).Serum qHbcrAg,pgRNA,HbV DNA,hepatitis b core antigen,HbeAg,liver cccDNA,and HbV DNA were *** correlations of serum qHbcrAg with other biomarkers were *** A total of 139 patients were *** mean qHbcrAg levels were 5.32±1.18 log10 U/mL at baseline and decreased during treatment(all PbcrAg levels were positively correlated with pgRNA(r=0.597,PbcrAg level and intrahepatic HbV DNA levels at baseline was weak but significant(r=0.399,PbcrAg predicted HbeAg seroconversion,with areas under the receiver operating characteristics curve of 0.788 at 24 wk and 0.825 at 48 *** HbcrAg at wk 24 and 48 was independently associated with HbeAg seroconversion[odds ratio(OR)=2.402,95%confidence interval(CI):1.314-4.391,P=0.004;OR=3.587,95%CI:1.315-9.784,P=0.013].CONCLUSION Serum HbcrAg levels were correlated with HbV virological markers and could be used to predict HbeAg seroconversion.

关键词： hepatitis b virus hepatitis b core antigen hepatitis b virus DNA Detection Liver biopsy Pregenomic RNA Quantitative hepatitis b core-related antigen Receiver operating characteristic Seroconversion Correlation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：