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screening for hepatitis b and c in Occupational Settings: cross-Sectional Study about 4268 corporates Agents in cote d’Ivoire

引用

Open Journal of Gastroenterology 2017年第3期7卷 89-95页

作者： constant Assi Amadou Ouattara Siaka Kone Dramane Soro Emile Allah-Kouadio claude Ghislain Kouakou Nigué Luc benoit-Mathieu camara Marie-Jeanne Lohoues-Kouacou Teaching Hospital center of cocody Abidjan Cote d’Ivoire

Aim: To screen hepatitis b and c in occupational setting. Methods: cross-sectional study multicenter in 16 enterprises (one occupational exposure;5602 agents). screening was preceded by information, sensibilisation and informed consenting physician labor, labor union and agents. hepatitis b surface antigen (HbsAg) and antibodies anti-hepatitis c (Elisa, third generation) were tested in all. For those with HbsAg positive, this test was completed by IgM and IgG, anti Hbc, HbeAg, antibodies anti Hbe, transaminases and Hbb DNA;for those with positive anti-VHc antibodies, test was completed by transaminases and VHc’s RNA. Results: Rate of participation was 76.2% (4268/5602 labors). HbsAg or hepatitis c antibodies were positives in 425 (9.9%) of cases (HbsAg positive: 8.48%;hepatitis c Antibodies positives: 1.50%;both: 0.05%). In HbsAg positive, viral replication and cytolysis were seen respectively in 2.5 % and 18.2%. According with transaminases, serologic markers and viral load, immunotolerance, inactive and immuno active phase were suspected in 0.56%, 80.9% and 1.6% of cases. In hepatitis c antibodies positives persons, any had viral replication but cytolysis was observed in 33.3% (n = 21). HbsAg was significantively (p ccupational enterprise versus non-occupational setting (14.4% vs 7.8%). They were no differences (p = 0.71) about hepatitis c antibodies in the two setting (1.8% vs 1.7%). conclusion: Prevalence of HbsAg and hepatitis c antibodies was high in occupational setting in hepatitis endemic country. It’s important to screen all of person in these setting with no consideration with blood exposed or not exposed enterprise.

关键词： hepatitis b and c screening Occupational Setting blood Exposed Enterprise

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