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hepatic veno-occlusive disease induced by Gymura segetum: report of two cases

Hepatobiliary & Pancreatic diseases International 2006年第3期5卷 406-408页

作者： Hui-Fen Dai, Yuan Gao, Ming Yang, Chao-Hui Yu, Zhu-Ying Gu and Wei-Xing Chen Zhejiang University School of Medicine, Hangzhou 310031, China Department of Emergency Medicine and Department of Gastroenterology , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome is associated with a high mortality because of its severity. Gymura segetum, a Chinese herbal medicine, is always used to cure injury and bleeding in rural areas in China. This study was undertaken to better understand VOD and its relations to the effect of Gymura segetum. METHODS: Between 2000 and 2002,two patients were admitted to our department because of VOD. Before admission, both of them had been injured and taken oral decoction of patent drug Gymura segetum. We analyzed the clinical manifestations, diagnosis and therapy of the two patients. RESULTS: Pyrrolizidine in Panax notginseng was proved to induce VOD. The diagnosis of VOD depended on hepatic biopsy. CONCLUSION: Gymura segetum can induce VOD. More attention should be paid to its unsuscepted side effects.

关键词： hepatic veno-occlusive disease ascites drugs, Chinese herbal liver transplantation

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A case report of hepatic veno-occlusive disease after ingesting dainties

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World Journal of Gastroenterology 2006年第41期12卷 6734-6735页

作者： Yong-Song Guan Department of Radiology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

hepatic veno-occlusive disease (HVOD) is rarely encountered and easily misjudged as Budd-Chiari syndrome. It is often related to stem cell transplantation in recent years. We report a case of HVOD that is related to ingestion of some palatable local dishes. The diagnosis was confirmed by liver biopsy pathology with specific observation of inflammatory changes and fibrosis of venules intima, dilated sinusoids and central veins. Chronic diarrhea is unique for this case as a result of ingesting harmful stuffs. This case demonstrated that supervision and instruction of food recipe and traditional medicine are crucial, and prompt diagnosis, supportive care and specific treatment are essential to decreasing the morbidity and mortality of HVOD.

关键词： hepatic veno-occlusive disease Diagnosis Management Biopsy

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Clinical characteristics and outcomes of patients with hepatic veno-occlusive disease induced by Gynura segetum: A retrospective study

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Journal of Integrative Medicine 2020年第5期18卷 434-440页

作者： Meng-xiao Feng Yan Shen Yuan-qiang Lu Department of Emergengy Medicine the First Afiliated HospitalSchool of MedicineZhejiong UniversityHangzhou 310003Zhejiang ProvinceChina Department of Geriatric Medicine the First Afliated HospitalSchool of MedicineZhejiang UniversityHangzhou 3100030 Zhejiang ProvinceChina Zhejiang Provincial Key Laborotory for Dignosis and Treatment 0f Aging and Physiccemical Injury diseases the First Aliliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003.Zhefiang ProvinceChina Department of Hepaobillary and Pancrearic Surgery.the First Afilited Hospial School of Medicine.Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

Objective: hepatic veno-occlusive disease(HVOD) has attracted increasing attention in recent years due to its relationship with ingestion of Gynura segetum. The mortality of severe HVOD remains high due to the lack of specific therapies. The aim of the study was to delineate the clinical characteristics and outcomes and explore the potential prognostic factors of ***: This was a single-center retrospective study. Eighty-nine HVOD patients were screened from the First Affiliated Hospital of Zhejiang University with an ingestion history of G. segetum before developing symptoms from January 2009 to May 2018. The enrolled patients were divided into the survivor and death groups according to the clinical follow-up that ended on September 1, 2019. The demographic variables and clinical data of the patients were recorded. A binary logistic regression analysis and receiver operating characteristic curve were conducted to identify the prognostic factors and assess the prognostic value for predicting death, and a survival analysis was performed to evaluate the clinical ***: Sixty-four patients were eligible for further analysis. Most patients showed abdominal distension and were positive for migrating dullness in the abdomen(P = 0.740 and P = 0.732, respectively). The patients who died had higher levels of model for end-stage liver disease score, and higher prothrombin time than those who survived(both P hepatic blood ***, we found that hydrothorax was detected in 21(65.63%) patients in the death group and 19(59.38%) patients in the survivor group during hospitalization, which was rarely mentioned in previous studies. Furthermore, international normalized ratio(INR) and creatinine are found to be potential independent prognostic factors for predicting death. Six severe patients achieved clinical

关键词： hepatic veno-occlusive disease Gynura segetum Clinical characteristics Prognostic Survival analysis

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Gynura root induces hepatic veno-occlusive disease:A case report and review of the literature

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World Journal of Gastroenterology 2007年第10期13卷 1628-1631页

作者： Ning Dai Ying-Cong Yu Tian-Hua Ren Jia-Guo Wu Yuan Jiang Lai-Gen Shen Jing Zhang Department of Hepato-Gastroenterology Sir Run Run Shaw Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310016 Zhejiang Province China Department of-Surgery Sir Run Run Shaw Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310016 Zhejiang Province China Department of Pathology Sir Run Run Shaw Affiliated Hospital of Medical College of Zhejiang University Hangzhou 310016 Zhejiang Province China

Gynura root has been used extensively in Chinese folk medicine and plays a role in promoting microcirculation and relieving ***,its hepatic toxicity should not be ***,we admitted a 62-year old female who developed hepatic veno-occlusive disease(HVOD)after ingestion of Gynura *** a few articles on HVOD induced by Gynura root have been reported in the *** is suspected that pyrrolizidine alkaloids in Gynura root might be responsible for *** this paper,we report a case of HVOD and review the literature.

关键词： hepatic veno-occlusive disease Gynura root

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One patient of hepatic veno-occlusive disease with an increased cancer antigen-125 expression caused by misuse of Sedum aizoon

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TMR Clinical Research 2018年第1期1卷 15-19页

作者： Siliang Wu Affiliated Hospital of Hunan College of Traditional Chinese Medicine Zhuzhou412000

Nowadays hepatic veno-occlusive disease is mainly caused by Sedum aizoon in China,and its prognosis dependents on the dosage and courses of the Sedum aizoon treatment but lacks other objective *** are a lot relationships between CA125 level and liver cirrhosis,this case had a obvious increased CA125 level in the serum,hydrothorax and ascites,following by the liver cirrhosis in a short time,and then died of upper gastrointestinal *** now we guess that CA125 level could forecast the liver cirrhosis following by hepatic veno-occlusive,which will become the prognosis of the hepatic veno-occlusive.

关键词： hepatic veno-occlusive disease Sedum aizoon Cancer antigen-125

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