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Psoraleae induces hepatotoxicity by affecting bile acid balance

Asian Toxicology Tesearch 2021年第1期3卷 15-22页

作者： Wei-Ling Pu Bin Yu An-Hong Wang Ya-Nan Bi Hong Shi Kun Zhou Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Gansu Provincial Hospital Lanzhou731600China Tianjin Key Laboratory of Chinese medicine Pharmacology Tianjin 301617China

Buguzhi(Psoraleae fructus),the seed of Psoralea corylifolia Linn,is used to treat osteoporosis,nephritis,vitiligo and other ***,long-term routine or overdose of Psoraleae fructus may lead to hepatotoxicity and become a major obstacle of its clinical *** was a key active component of Psoraleae fructus,and a main cause of Psoraleae fructus *** research was to investigate the hepatotoxicity of psoralen and whether it’s related with bile acid ***:C57BL/6 mice were randomly divided into 4 groups(n=10).Psoralen(20 mg/kg,40 mg/kg and 80 mg/kg)was administrated intragastrically once every day and control group with equivalent water until 4 ***:The results showed that psoralen caused an increase in liver coefficient and the injury of hepatocytes microstructure of *** also inhibited cell viability of HepG2 *** treated with psoralen exerted liver total bile acid increased while serum total bile acid decreased,which indicated that psoralen-induced liver injury may partly associate with *** further study of liver transporters,high dose of psoralen inhibited the expression of some important hepatic efflux transporters(including BSEP,p-gp and ABCG5)in vivo and in ***:We provide evidence for the first time that psoralen may induce cholestatic hepatotoxicity for the bile acid retention by inhibition on bile acid export pumps.

关键词： Psoralen Hepatotoxicity Bile acid hepatic transporter

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