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Primary hepatic angiosarcoma manifesting as hepatic sinusoidal obstruction syndrome:A case report

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World Journal of Gastrointestinal Oncology 2022年第5期14卷 1050-1056页

作者： Fu-Shuang Ha Hua Liu Tao Han De-Zhao Song The Third Central Clinical College of Tianjin Medical University Tianjin 300170China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin 300170China Artificial Cell Engineering Technology Research Center Tianjin 300170China Tianjin Institute of Hepatobiliary Disease Tianjin 300170China Tianjin Union Medical Center Naikai University Affiliated HospitalTianjin 300121China

BACKGROUND Primary hepatic angiosarcoma(PHA)is a rare malignancy with a poor *** is difficult to diagnose PHA because of the lack of specific symptoms or tumour markers,and it rapidly progresses and has a high *** our knowledge,PHA has not been reported to mimic hepatic sinusoidal obstruction ***,we present a case of PHA manifesting as hepatic sinusoidal obstruction syndrome,diagnosed using transjugular liver biopsy,that resulted in the death of the *** SUMMARY A 71-year-old man was admitted with the primary complaint of abdominal distension,decreased appetite,fatigue in the previous month,and loss of 10 kg of weight in the past 2 *** the liver and spleen were enlarged,and the liver had a medium-hard texture on *** examinations were performed,and abdominal plain computed tomography(CT)and contrastenhanced CT showed hepatomegaly and splenomegaly,as well as diffuse lowdensity shadows distributed in the liver and ***-enhanced CT revealed diffuse,hypodense,nodular or flake shadows in the liver and heterogeneous enhancement in the spleen.A transjugular liver biopsy was *** on the pathology results,the patient was diagnosed with hepatic sinusoidal obstruction syndrome secondary to *** patient’s status further deteriorated and he developed serious hepatic *** patient was discharged,and died 3 d *** PHA is rare and has a poor prognosis;however,transjugular liver biopsy can be safely performed to aid in diagnosis.

关键词： hepatic angiosarcoma hepatic sinusoidal obstruction syndrome Outcome Primary cancer High mortality Case report

Rapidly Progressing hepatic angiosarcoma Terminally Cared for at Home: A Case Discussion—hepatic angiosarcoma Taken Palliative Care at Home

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Case Reports in Clinical Medicine 2024年第11期13卷 477-484页

作者： Hiroaki Yamane Aki Yoshimitsu Tomoko Itagaki Motoi Yamane Department of Surgery Yamane Clinic Hiroshima Japan Department of Clinical Oncology Hiroshima General Hospital Hiroshima Japan

Background: hepatic angiosarcoma is a rare disease with a poor prognosis due to its tendency for distant sites. Few opportunities exist for palliative treatment of hepatic angiosarcomas at home. Here, we report a rare case of palliative treatment of hepatic angiosarcoma at home. Case Presentation: An 87-year-old male patient complained of upper abdominal pain and anorexia, persisting for 2 months. Computed tomography revealed multiple tumors in the liver, spleen, left kidney, and bone. hepatic angiosarcoma was diagnosed based on the liver biopsy results. Due to his advanced age and dementia, the patient and his family decided to receive palliative treatment at home, thereby initiating home medical care at our clinic. During the first visit, oral opioid medication was introduced, and home oxygen therapy (HOT) was initiated because of complaints of cancer pain and respiratory distress. As oral intake became difficult, the patient was switched to a patch opioid, and suppositories were used for ton use. The patient was treated with morphine and HOT;however, the improvement in respiratory distress was below acceptable. The patient died at home on the ninth day after his visit. Conclusion: To the best of our knowledge, this is the first case report on palliative care for hepatic angiosarcoma at home. Owing to the rapid progression of this disease, home physicians must know its characteristics and provide appropriate medical care.

关键词： hepatic angiosarcoma Home-Based Palliative Care Service Home Oxygen Therapy Invasive Tumor

hepatic angiosarcoma:an analysis of 7 cases

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The Chinese-German Journal of Clinical Oncology 2011年第8期10卷 484-486页

作者： Dongzhi Yin Qichang Zheng Youneng Yuan Huangshi Center Hospital Huangshi 435000 China Department of Hepatobiliary Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： The aim of our study was to evaluate and sum up the experience with hepatic angiosarcoma. Methods： Retrospective study of 7 patients with hepatic angiosarcoma. Results： Symptoms and signs such as abdominal pain were extremely nonspecific. The levels of the tumor markers were within the normal range. Four cases were positive for hepatitis B viruses. Among the 5 patients who received chemotherapy, improvement in survival was seen in 3 cases which also received surgery. Conclusion： hepatic angiosarcoma is a rare and diffficult-to-diagnose malignant liver tumor. Surgery is the definitive treatment and adjuvant chemotherapy after surgery may improve survival.

关键词： hepatic angiosarcoma treatment

A pooled analysis of treatment and prognosis of hepatic angiosarcomain adults

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 198-203页

作者： De-Bang Li Xiao-Ying Si Tao Wan Yan-Ming Zhou Department Ⅲ of General Surgery The First Hospital of Lanzhou University Lanzhou 730000 China Department of Hepatobiliary & Pancreatovascular Surgery First Affiliated Hospital of Xiamen University Xiamen 361003 China

Background： hepatic angiosarcoma is a rare malignant vascular tumor presenting unique treatment *** aim of the present study was to determine the treatment and prognosis of this *** sources： A systematic literature search was conducted using PubMed, Embase and Chinese BiomedicalLiterature database, to identify articles published from January 1980 to July 2017. Search termswere “hepatic angiosarcoma” and “liver angiosarcoma”. Additional articles were retrieved through manualsearch of bibliographies of the relevant articles. Pooled individual data concerning the prognosis followingvarious therapeutic modalities were analyzed.

关键词： hepatic angiosarcoma Liver transplantation Hepatectomy Treatment Prognosis

Primary malignant vascular tumors of the liver in children:angiosarcoma and epithelioid hemangioendothelioma

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 223-230页

作者： Sami Bannoura Juan Putra Department of Paediatric Laboratory Medicine Hospital for Sick Children555 University AveToronto M5G 1X8OntarioCanada

Primary malignant vascular neoplasms of the liver,angiosarcoma and epithelioid hemangioendothelioma,are extremely rare entities in the pediatric *** Society for the Study of Vascular Anomalies classification system is recommended for the pathologic diagnosis of hepatic vascular lesions in this age *** this article,we highlight the clinicopathologic characteristics of hepatic angiosarcoma and epithelioid hemangioendothelioma in the pediatric *** angiosarcoma in children shows a slight female predominance with an average age of 40 mo at *** distinct histologic features include whorls of atypical spindled cells and eosinophilic globules,in addition to the general findings of *** diagnosis of pediatric hepatic angiosarcoma is not always straightforward,and the diagnostic challenges are discussed in the *** epithelioid hemangioendothelioma also demonstrates a female predominance,but is more commonly identified in adolescents(median age at diagnosis:12 years).Histologically,the lesion is characterized by epithelioid cells and occasional intracytoplasmic lumina with a background of fibromyxoid *** WWTR1-CAMTA1 and YAP1-TFE3 fusions have been associated with epithelioid hemangioendothelioma,there are currently no known signature genetic alterations seen in pediatric hepatic *** in molecular pathology,particularly for pediatric hepatic angiosarcoma,is necessary for a better understanding of the disease biology,diagnosis,and development of targeted therapies.

关键词： Pediatric hepatic angiosarcoma Epithelioid hemangioendothelioma Infantile hemangioma Liver tumor Molecular genetics

Pediatric vascular tumors of the liver:Review from the pathologist’s point of view

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World Journal of Hepatology 2021年第10期13卷 1316-1327页

作者： Fleur Cordier Anne Hoorens Jo Van Dorpe David Creytens Department of Pathology Ghent University HospitalGhent UniversityGhent 9000Belgium

Differential diagnosis of pediatric vascular liver tumors can be challenging due to inconsistent nomenclature,histologic overlap and the rarity of some *** we give an up-to-date overview of the most important *** discuss the clinic,histology and pathophysiology of hepatic congenital and infantile heman-gioma,hepatic epithelioid hemangioendothelioma and hepatic angio-sarcoma.

关键词： hepatic congenital hemangioma hepatic infantile hemangioma hepatic epithelioid hemangioendothelioma hepatic angiosarcoma hepatic vascular tumors of infancy hepatic hemangiomas

Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management

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World Journal of Clinical Oncology 2019年第3期10卷 110-135页

作者： Daniela Cornelia Lazar Mihaela Flavia Avram Ioan Romosan Violetta Vacariu Adrian Goldis Marioara Cornianu Department of Internal MedicineⅠ University Medical ClinicUniversity of Medicine and Pharmacy“Victor Babes”Timisoara 300041Romania Department of SurgeryⅩ 1st Surgery ClinicUniversity of Medicine and Pharmacy“Victor Babe?”Timisoara 300041Romania Department of Gastroenterology and Hepatology University of Medicine and Pharmacy“Victor Babes”Timisoara 300041Romania Department of Pathology University of Medicine and Pharmacy“Victor Babes”Timisoara 300041Romania

Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each *** on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver.

关键词： hepatic malignant vascular tumors hepatic small vessel neoplasia hepaticperivascular epithelioid cell tumor hepatic hemangiopericytoma hepatic epithelioidhemangioendothelioma Kaposi sarcoma hepatic angiosarcoma Diagnostic Prognostic Treatment