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Retroperitoneal schwannoma mimicking hepatic tumor

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Chinese Medical Journal 2008年第17期121卷 1751-1752页

作者： GU Lei LIU Wei XU Qing WU Zhi-yong Department of General Surgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Retroperitoneal tumors are difficult to distinguish, .especially because they share common radiological features with tumors of the liver. When we come across such tumors, the clinical diagnosis is often confusing. He... 详细信息

关键词： retroperitoneal schwannoma hepatic tumor differential diagnosis

Proteomic analysis of hepatic tumor in Hras12V transgenic mice

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Proteomic analysis of hepatic tumor in Hras12V transgenic mi...

Primary hepatic neuroendocrine tumor—_(18)F-fluorodeoxyglucose positron emission tomography/computed tomography findings:A case report

2017年第十五届中国北方实验动物科技年会

作者： Zhuona Rong Tingting Fan Huiling Li Juan Li Fujin Wang Jingyu Wang Aiguo Wang Laboratory animal center Dalian Medical University

Male prevalence is an outstanding characteristic of hepatocellular carcinoma（HCC）,and the underlying mechanisms for this have remained largely *** the present study,Hras12 V transgenic mice,in which hepatocyte-specific expression of the ras oncogene induces male-biased hepatic tumorigenesis,were studied,and altered proteins were detected by two-dimensional fluorescence difference gel electrophoresis（2 D-DIGE）.Protein samples from hepatic tumor tissues（T） and peri-tumor tissues（P） of transgenic males and females and the corresponding normal liver tissues（Wt） of non-transgenic males and females were subjected to pairwise comparisons based on proteomic *** 2381 auto-detected protein spots,more than1600 were differentially expressed based on a pairwise comparison（|ratio| ＞= 1.5,p ＜= 0.05）.Of these,180 spots were randomly selected for matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry（MALDI-TOF/TOF MS） identification;finally,89 distinct proteins were *** these 89 proteins,7 and 50 proteins were further validated by Western blotting and literature investigation,***,compared to Wt,the altered proteins were relatively concentrated in T in transgenic females but in P in transgenic ***,the levels of p-ERK and p-mTOR were significantly higher in the T of females compared to that of *** pathway enrichment assay showed that 5 pathways in males but only 1 in females were significantly altered in terms of the up-regulated proteins in T compared to *** data indicate that female hepatocytes are disturbed by oncogenes with great difficulty,whereas male hepatoctyes readily do *** addition,33 proteins were genderdependently altered in hepatic ***,4%DNA packaging and 4%homeostasis-related functional proteins were found in females but not in males,and more nucleus proteins were found in females（8%） than in males（3%）.In conclusion,the proteomic data and compar

关键词： hepatic tumor Ras oncogene Gender-dependent Proteomics Two-dimensional fluorescence difference gel electrophoresis(2D-DIGE)

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World Journal of Clinical Cases 2021年第22期9卷 6450-6456页

作者： Yan-Ying Rao He-Jun Zhang Xiao-Jiang Wang Min-Feng Li Department of Radiology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFuzhou 350000Fujian ProvinceChina Department of Pathology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND Primary hepatic neuroendocrine tumors(PHNETs)are rare hepatic *** diagnosis,which is based on radiological findings,is *** SUMMARY We present a case of PHNET in a 79-year-old man with no clinical *** tomography(CT)and 2-Deoxy-2-[fluorine-18]fluorodeoxyglucose positron emission tomography/CT(18F-FDG PET/CT)were performed for further evaluation.A hypoattenuating mass with rim-like enhancement in segment 6 of the liver was detected on contrast-enhanced CT *** uptake was also observed on 18F-FDG PET/*** and immunohistochemical examinations,which revealed a grade 2 neuroendocrine tumor(NET),confirmed the *** Diagnosing PHNET is challenging,and must be distinguished from other liver *** NETs should be excluded.

关键词： hepatic tumor Neuroendocrine Positron emission tomography Computed tomography Case report

Symptomatic pulmonary lipiodol embolism after transarterial chemoembolization for hepatic malignant tumor： clinical presentation and chest imaging findings

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Chinese Medical Journal 2014年第4期127卷 675-679页

作者： Xu Haifeng Yang Renjie Wang Xiaodong Zhu Xu Chen Hui Department of Interventional Therapy Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital &amp Institute Beijing 100142China

Background Pulmonary lipiodol embolism after transarterial chemoembolization （TACE） was rare and life-threatening,occasionally reported in previous *** aimed to review the records of 11 patients with pulmonary oily embolism and analyze their characteristics of radiographic findings and risk *** Records of 478 consecutive patients who underwent 1 026 percutaneous TACE procedures were retrospectively *** cases with respiratory symptoms were identified as having symptomatic pulmonary lipiodol embolism after *** of these patients,including clinical presentation,techniques of TACE,imaging features of tumor and chest imaging findings,were *** Eleven （2.3%） of 478 consecutive patients who underwent percutaneous TACE procedures had a pulmonary oily embolism after *** mean size of target tumors embolized was （13.6＆#177;2.0） *** were *** mean volume of lipiodol was （21.8＆#177;8.2） *** oily embolisms were revealed within 12-48 hours after *** most severe respiratory symptoms and imaging abnormalities of the eight patients who survived presented between 2 and 5 days after TACE,becoming normal between 12 and 35 days after *** patients *** CT revealed retention of radiopaque lipiodol in *** Pulmonary lipiodol embolism occurs easily in patients who have large hyper-vascular hepatic malignant *** high-density lipiodol deposition in the lung field can be used as diagnostic feature.

关键词： lipiodol pulmonary embolism hepatic tumor complications transarterial chemoembolization

hepatic perivascular epithelioid cell tumor:Clinicopathological analysis of 26 cases with emphasis on disease management and prognosis

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World Journal of Gastroenterology 2021年第35期27卷 5967-5977页

作者： Shan Zhang Pan-Pan Yang Yu-Chen Huang Hong-Chun Chen De-Li Chen Wen-Tian Yan Ning-Ning Yang Yuan Li Nan Li Zhen-Zhong Feng Department of Pathology The Second People’s Hospital of HefeiHefei 230011Anhui ProvinceChina Department of Pathology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Perivascular epithelioid cell tumor(PEComa)is an uncommon tumor of mesenchymal *** of PEComa in the liver are extremely *** To analyze the clinicopathological features and treatment of hepatic PEComa and to evaluate the prognosis after different *** Clinical and pathological data of 26 patients with hepatic PEComa were *** cases were analyzed by immunohistochemistry and clinical *** This study included 17 females and 9 males,with a median age of 50 *** were located in the left hepatic lobe in 13 cases,in the right lobe in 11,and in the caudate lobe in *** median tumor diameter was 6.5 *** microscopy revealed that the tumor cells were mainly composed of epithelioid *** cytoplasm contained heterogeneous eosinophilic *** were thick-walled blood vessels,around which tumor cells were radially *** analysis of pigment-derived and myogenic markers in PEComas revealed that 25 cases were HMB45(+),23 were Melan-A(+),and 22 SMA(+).TFE3 and Desmin were negative in all *** the fluorescence in situ hybridization samples were negative for TFE3 gene break-apart *** tissues were collected by extended hepatic lobe resection or simple hepatic tumor resection as the main *** follow-up was 62.5 *** of the patients had metastasis or recurrence,and there were no deaths due to the *** hepatic PEComa highly expresses melanin and smooth muscle markers,and generally exhibits an inert biological *** prognosis after extended hepatic lobe resection and simple hepatic tumor resection is semblable.

关键词： hepatic tumor Perivascular epithelioid cells PEComa Immunohistochemistry Treatment Prognosis

Differential response of multiple zebrafish hepatic F-box protein genes to 17α-ethinylestradiol treatment

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Journal of Environmental Sciences 2011年第4期23卷 664-670页

作者： Hongping Zheng Shifeng Li Zhili Wu Yunbin Zhang Shengnan Hu Yuanchang Yan Yiping Li Shanghai Key Laboratory for Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China.

Estrogens are accumulating in environment and their effects on a variety of reproductive processes and tumorigenesis were reported by previous study, but the mechanism of estrogen promoting neoplasia was still not clear. F-box protein （FBP） is the component of E3 ubiquitin ligase which takes part in a variety of key biological processes. In this study, using mature male zebrafish, which are more sensitive to estrogen treatment, we examined influence of 17α-ethinylestradiol （EE2） exposure on the expression of a series of hepatic FBP genes, which take part in a variety of biological processes, including tumorigenesis. The influence of EE2 on the expression of hepatic mRNA concentrations of FBP genes were quantified based on the expression of the optimal internal control gene in male zebrafish after 7-day exposure to EE2, from a low-dose concentration （1 ng/L） to environmentally relevant concentrations （10, 100 ng/L）. Our results showed that EE2 exposure reduced the expression of fbxl14a, fbxl14b, fbxo25 and β-TRCP2b, but enchanced the expression of skp2. While the alterations in fbxl2, fbxw7, fbxo9, β-TRCP2a, fbxl18 and fbxo45 mRNA levels were not observed after EE2 exposure. Thus, our results showed that the expression of hepatic FBP genes exhibited differentially in male zebrafish exposed EE2. The changes of the expression level of FBP genes induced by EE2 may be an important clue to elucidate the correlations of estrogen and hepatic tumors.

关键词： estrogen 17α-ethinylestradiol F-box hepatic tumor zebrafish

Radiofrequency ablation for incidentally identified primary intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2005年第33期11卷 5239-5240页

作者： Witold Zgodzinski N.Joseph Espat Second Department of General Surgery Skubiszewski Medical University of Lublin Staszica 16 20-081 Lublin Poland Department of Hepatobiliary Surgery University of Illinois at Chicago 840 South Wood Street Chicago IL 60612 United States

Cholangiocarcinoma is the second most common primary hepato-biliary malignancy. The majority of patients with primary hepatic tumors are not suitable candidates for resection, due to advanced stage of the disease at presentation, anatomic limitations and medical comorbidities. At present, radiofrequency ablation (RFA) may offer an alternative, feasible and safe therapy for selected patients with hepatic tumors, who are not otherwise candidates for hepatic resection. Herein, we present the case of successful RFA in a patient with a solitary, primary intrahepatic cholangiocarcinoma. The patient remained free of disease 24 mo after the procedure, and is still followed up. This is the first report of RFA application inthe treatment of primary intrahepatic cholangiocarcinoma.

关键词： Cholangiocarcinoma Radiofrequency ablation hepatic tumor

Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions

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World Journal of Gastroenterology 2009年第46期15卷 5805-5812页

作者： Naoto Koike Akihiro Cho Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya Yuji Ohshima Nobuhiro Ohkohchi Department of Surgery Seirei Sakura Citizen Hospital Department of Surgery Chiba Cancer Center Department of Radiology Institute of Clinical MedicineUniversity of Tsukuba Department of Radiology Seirei Sakura Citizen Hospital Department of Radiology Seirei Mikatabara Hospital Department of Surgery Institute of Clinical MedicineUniversity of Tsukuba

AIM： To evaluate the utility of diffusion-weighted imaging （DWl） in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS： Magnetic resonance imaging （MRI） examinations were performed using the Signa Excite Xl Twin Speed 1.5T system （GE Healthcare, Milwaukee, Wl, USA）. Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas （HCC）, four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio （RCR）, and apparent diffusion coefficient （ADC） were compared between benign and malignant lesions on DWl. Su- perparamagnetic iron oxide （SPIO） was administered to 59 patients, and RCR was compared pre- and ***： DWI showed higher contrast between malignant lesions （especially in multiple small metastatic cancers） and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs （mean±SD × 10^-3 mm2/s） were significantly lower （P 〈 0.05） in malignant lesions （HCC： 1.31 ± 0.28 and liver metastasis： 1.11 ± 0.22） and were significantly higher in benign lesions （hemangioma： 1.84 ± 0.37 and cyst： 2.61 ± 0.45） than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding he- patic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not ***： DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis.

关键词： hepatic tumor Liver imaging Magneticresonance imaging Diffusion-weighted imaging Apparent diffusion coefficient

Radiofrequency ablation in the management of primary hepatic and biliary tumors

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 203-215页

作者： Richard Hendriquez Tara Keihanian Jatinder Goyal Rtika R Abraham Rajnish Mishra Mohit Girotra Department of Internal Medicine University of Central FloridaOrlandoFL 32816United States Department of Gastroenterology and Hepatology University of MiamiMiamiFL 33136United States Department of Gastroenterology and Hepatology Wellspan Digestive Health-York HospitalYorkPA 17403United States Department of Endocrinology Swedish Medical CenterSeattleWA 98104United States

In the United States,80%-90%of primary hepatic tumors are hepatocellular carcinomas and 10%-15%are cholangiocarcinomas(CCA),both with high mortality rate,particularly CCA,which portends a worse *** management with surgery has good outcomes in appropriately selected patients;however,novel ablative treatment options have emerged,such as radiofrequency ablation(RFA),which can improve the prognosis of both hepatic and biliary *** is aimed to generate an area of necrosis within the targeted tissue by applying thermal therapy via an electrode,with a goal to completely eradicate the tumor while preserving surrounding healthy *** of RFA in management of hepatic and biliary tumors forms the focus of our current mini-review article.

关键词： Radiofrequency ablation Radiofrequency ablation hepatic tumor Biliary tumor Cholangiocarcinoma Hepatocellular carcinoma Cholangiocarcinomas Hepatocellular carcinomas