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Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum

World Journal of Gastroenterology 2008年第18期14卷 2905-2911页

作者： Hui Chen Yong-Wen He Wen-Qi Liu Jing-Hui Zhang Department of Infectious Disease Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China Department of Parasitology Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China Department of Surgical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

AIM: To evaluate the effect of rosiglitazone in a murine model of liver fibrosis induced by Schistosoma japonicum infection. METHODS: A total of 50 mice were randomly and averagely divided into groups A, B, C, D and E. The mice in group A served as normal controls, while those in the other four groups were infected with Schistosoma japonicum to induce the model of liver fibrosis. Besides, the mice in groups C, D and E were treated with praziquantel, rosiglitazone and praziquantel plus rosiglitazone, respectively. NF-κB binding activity and expression of PPARγ-mRNA were determined by Western blot assay and real-time quantitative PCR. Radioimmunonassay technique was used to detect the serum content changes of TNF-α and IL-6. Histological specimens were stained with HE. Expression of TGF-β1, a-smooth muscle actin and type ?Ⅰ?and type Ⅲ collagen was detected by immunohistochemistry and multimedia color pathographic analysis system. RESULTS: Inflammation and fibrosis in the rosiglitazone plus praziquantel treatment group (group E) were lightest among the mice infected with Schistosoma (P hepatic expression of TGF-β1, α-SMA type Ⅰand type Ⅲ collagen in mice with liver fibrosis. CONCLUSION: The activation of PPARγ by its ligand can retard liver fibrosis and suggest the use of rosiglitazone for the treatment

关键词： Peroxisome proliferators-activated receptor γ Rosiglitazone Liver fibrosis Schistosomiasis hepati cstellate cell

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